Protein detail
PARD3
Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)
Entry name PARD3 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)
Protein Class (3)
Disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function (2)
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (6)
ASIPBazBazookaPAR3PARD3APPP1R118
Gene Description
Par-3 family cell polarity regulator
Chromosome
10
Position
34109560-34815325
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization3
Cell SpecificLymphatic endothelial cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway7
Protein Function (2)
- Disease related genes
- Predicted intracellular proteins
Cellular Component (14)
- GO:0005829 cytosol
- GO:0005856 cytoskeleton
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0005912 adherens junction
- GO:0005923 bicellular tight junction
- GO:0005938 cell cortex
- GO:0012505 endomembrane system
- GO:0016324 apical plasma membrane
- GO:0030054 cell junction
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Molecular Function (5)
Biological Process (3)
KEGG (9)
Reactome (6)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence35
Enzyme-Mediated Modification (9)
9 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PARD3 | AURKA | O14965 | S | 962 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperdbPTMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:19812038ProtMapper:19812038dbPTM:19812038 |
| PARD3 | MARK2 | Q7KZI7 | S | 873 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:22883624ProtMapper:22883624 |
| PARD3 | MARK2 | Q7KZI7 | S | 144 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| PARD3 | PRKCZ | Q05513 | S | 827 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:12390250ProtMapper:12390250 |
| PARD3 | PRKCI | P41743 | S | 827 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| PARD3 | AURKB | Q96GD4 | S | 962 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| PARD3 | F2R | P25116 | S | 144 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:27462467 |
| PARD3 | F2R | P25116 | S | 873 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:27462467 |
| PARD3 | CDK1 | P06493 | S | 383 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (17)
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | No | No | No |
| tight_junction | tight_junction | Ramilowski_location | Yes | Yes | No | No | No |
| tight_junction | tight_junction | OmniPath | Yes | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network (5)
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCZ | Q05513 | PARD3 | Q8TEW0 | Yes | Yes | No | WangiPTMnetSIGNORProtMapperSignaLink3SIGNOR_ProtMapperTCRcuration_SignaLink3 | SignaLink3:24152735SignaLink3:23109003SIGNOR:12390250SignaLink3:17353362ProtMapper:12390250 |
| PARD3 | Q8TEW0 | TIAM1 | Q13009 | Yes | No | Yes | WangHPRDHINTSignaLink3SPIKE_LCTCRcuration_SignaLink3 | SignaLink3:24152735HPRD:15723052SignaLink3:23109003SignaLink3:17353362HINT:17053785HINT:23263278SPIKE_LC:17053785 |
| AURKA | O14965 | PARD3 | Q8TEW0 | Yes | Yes | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperdbPTMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:19812038PhosphoSite:19812038ProtMapper:19812038dbPTM:19812038 |
| MARK2 | Q7KZI7 | PARD3 | Q8TEW0 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:22883624PhosphoSite:22883624PhosphoSite:14653998ProtMapper:22883624 |
| KPCI | P41743 | PARD3 | Q8TEW0 | Yes | Yes | No | WangiPTMnetPhosphoPointProtMapperHPRDHINTIntActSPIKE_LCPhosphoSitePhosphoSite_ProtMapper | HINT:14676191IntAct:14676191SPIKE_LC:17145710PhosphoSite:27554858HPRD:14676191HINT:12459187SPIKE_LC:14676191 |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| INSC-LGN-PAR3 complex | GPSM2INSCPARD3 | P81274Q1MX18Q8TEW0 | 0:0:0 | CORUM | CORUM:7559 | 16458856 |
| Tiam1-Par-3-aPKC-zeta complex | PARD3PARD3BPRKCZTIAM1TIAM2 | Q05513Q13009Q8IVF5Q8TEW0Q8TEW8 | 1:1:1:1:1 | Compleat | Compleat:HC1133 | 16186252 |
| PARD3RASSF8 | Q8NHQ8Q8TEW0 | 0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 28396511 |
Sequence, Structure & Domains15
Sequences
Length
1,356
Mass
151,423
Sequence
MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNYWIQVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANMPLHVRRSSDPALIGLSTSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNARSSLSASHPMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLERQMNGNQEKGDKTDRKKDKTGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKDDKIEKTGKIKIQESFTSEEERIRMKQEQERIQAKTREFRERQARERDYAEIQDFHRTFGCDDELMYGGVSSYEGSMALNARPQSPREGHMMDALYAQVKKPRNSKPSPVDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQPWPNARPATQSGRHSVSVEVQMQRQRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQNYSPGEGFQSAKENPRYSSYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYAPPKGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS
Alternative Products
Event=Alternative splicing; Named isoforms=11; Name=1; Synonyms=A; IsoId=Q8TEW0-1; Sequence=Displayed; Name=2; Synonyms=B, La; IsoId=Q8TEW0-2; Sequence=VSP_007464; Name=3; Synonyms=C; IsoId=Q8TEW0-3; Sequence=VSP_007462, VSP_007463, VSP_007464, VSP_007465; Name=4; Synonyms=D; IsoId=Q8TEW0-4; Sequence=VSP_007469; Name=5; Synonyms=E; IsoId=Q8TEW0-5; Sequence=VSP_007462, VSP_007463, VSP_007464, VSP_007466, VSP_007468, VSP_007469; Name=6; Synonyms=F; IsoId=Q8TEW0-6; Sequence=VSP_007463, VSP_007464, VSP_007465; Name=7; Synonyms=Lb; IsoId=Q8TEW0-7; Sequence=VSP_007463, VSP_007464, VSP_007465, VSP_007469; Name=8; Synonyms=Sa; IsoId=Q8TEW0-8; Sequence=VSP_007464, VSP_007470, VSP_007471; Name=9; Synonyms=Sb; IsoId=Q8TEW0-9; Sequence=VSP_007463, VSP_007464, VSP_007465, VSP_007470, VSP_007471; Name=10; IsoId=Q8TEW0-10; Sequence=VSP_007464, VSP_007465, VSP_007467, VSP_007470, VSP_007471; Name=11; IsoId=Q8TEW0-11; Sequence=VSP_007463, VSP_007464
Alternative Sequence
195..238; Missing (in isoform 3 and isoform 5); 557..569; Missing (in isoform 3, isoform 5, isoform 6, isoform 7, isoform 9 and isoform 11); 740..742; Missing (in isoform 2, isoform 3, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 11); 827..856; Missing (in isoform 3, isoform 6, isoform 7, isoform 9 and isoform 10); 857..858; IA -> T (in isoform 10); 857; I -> S (in isoform 5); 858..872; Missing (in isoform 5); 1025..1061; Missing (in isoform 4, isoform 5 and isoform 7); 1025..1034; RFGKHRKDDK -> SLAKLKPEKR (in isoform 8, isoform 9 and isoform 10); 1035..1356; Missing (in isoform 8, isoform 9 and isoform 10)
3D Structural Models
Helix
498..501; 524..533
Beta Strand
458..465; 473..476; 481..485; 488..493; 507..514; 539..546
3D Structure
NMR spectroscopy (1)
Domain & Motif Annotations
Compositional Bias
91..100; Low complexity; 154..163; Polar residues; 171..187; Polar residues; 190..203; Basic and acidic residues; 204..224; Polar residues; 246..260; Basic and acidic residues; 939..953; Acidic residues; 968..982; Polar residues; 983..1009; Basic and acidic residues; 1136..1149; Polar residues; 1150..1177; Basic and acidic residues; 1196..1205; Low complexity; 1221..1245; Polar residues; 1285..1298; Basic and acidic residues; 1337..1346; Polar residues; 1347..1356; Basic and acidic residues
Coiled Coil
1049..1077; 1151..1174; 1201..1224; 1280..1301
Domain (CC)
Contains a conserved N-terminal oligomerization domain (NTD) that is involved in oligomerization and is essential for proper subapical membrane localization.; DOMAIN: The second PDZ domain mediates interaction with membranes containing phosphoinositol lipids.
Domain (FT)
271..359; PDZ 1; 461..546; PDZ 2; 590..677; PDZ 3
Region
81..100; Disordered; 154..262; Disordered; 408..448; Disordered; 712..936; Interaction with PRKCI and PRKCZ; 865..886; Disordered; 932..1025; Disordered; 935..1356; Interaction with FRMD4A; 1129..1356; Disordered
Protein Families
PAR3 family
Sequence Similarities
Belongs to the PAR3 family.
Clinical Relevance6
Disease Involvement
Disease variant
Drug Targets
Literature-reported target
Antibody
Interaction Protein (13)
ENSG00000102981ENSG00000108953ENSG00000124171ENSG00000128245ENSG00000134308ENSG00000136485ENSG00000163558ENSG00000164924ENSG00000166913ENSG00000168036ENSG00000170027ENSG00000175793ENSG00000178184
Interaction Count
13
Interaction Dataset (3)
intact_biogridbiogrid_opencellintact_biogrid_opencell
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 37427430 | Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis. | No abstract available |
| 40689422 | Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles. | No abstract available |