Protein detail

ZFP90

Zinc finger protein 90 homolog (Zfp-90) (Zinc finger protein 756)

Entry name ZFP90	UniProt ID Q8TF47	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteinsTranscription factors

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Zinc finger protein 90 homolog (Zfp-90) (Zinc finger protein 756)

Protein Class (2)

Predicted intracellular proteinsTranscription factors

Protein Function (2)

Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Ensembl

ENSG00000184939

Entrez Gene Symbol

ZFP90

Gene Synonym (3)

KIAA1954NK10ZNF756

Gene Description

ZFP90 zinc finger protein

Chromosome

Position

68530090-68576072

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization6

Tissue SpecificretinaCell SpecificAdipocytesSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellBlood Lineage SpecificNK-cells

Function & Pathway7

Protein Function (2)

Predicted intracellular proteins
Transcription factors:Zinc-coordinating DNA-binding domains

Cellular Component

GO:0005634 nucleus

Molecular Function (5)

Biological Process (3)

Reactome

R-hsa-73857 rna polymerase ii transcription

Canonical Pathways (3)

M5880 Naba ecm affiliated
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories

Other mediation

Relations & Evidence7

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
FOXP3-TRIM28-ZFP90 complex	FOXP3 TRIM28 ZFP90	Q13263 Q8TF47 Q9BZS1	0:0:0	CORUM	CORUM:6931	23543754
	ZFP2 ZFP90 ZNF565 ZNF567 ZNF71 ZNF75A	Q6ZN57 Q8N184 Q8N9K5 Q8TF47 Q96N20 Q9NQZ8	0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	5	40985879 38207106 37322475 40189497 27821849

Sequence, Structure & Domains9

Sequences

Length

636

Mass

73,031

Sequence

MAPRPPTAAPQESVTFKDVSVDFTQEEWYHVDPAQRSLYRDVMLENYSHLVSLGYQVSKPEVIFKLEQGEEPWISEGEIQRPFYPDWKTRPEVKSSHLQQDVSEVSHCTHDLLHATLEDSWDVSSQLDRQQENWKRHLGSEASTQKKIITPQENFEQNKFGENSRLNTNLVTQLNIPARIRPSECETLGSNLGHNADLLNENNILAKKKPYKCDKCRKAFIHRSSLTKHEKTHKGEGAFPNGTDQGIYPGKKHHECTDCGKTFLWKTQLTEHQRIHTGEKPFECNVCGKAFRHSSSLGQHENAHTGEKPYQCSLCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHGTSLTQHEVTHSGEKPFQCKECGKAFSRCSSLVQHERTHTGEKPFECSICGRAFGQSPSLYKHMRIHKRGKPYQSSNYSIDFKHSTSLTQDESTLTEVKSYHCNDCGEDFSHITDFTDHQRIHTAENPYDCEQAFSQQAISHPGEKPYQCNVCGKAFKRSTSFIEHHRIHTGEKPYECNECGEAFSRRSSLTQHERTHTGEKPYECIDCGKAFSQSSSLIQHERTHTGEKPYECNECGRAFRKKTNLHDHQRIHTGEKPYSCKECGKNFSRSSALTKHQRIHTRNKL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TF47-1; Sequence=Displayed; Name=2; Synonyms=FOXP3-interacting KRAB-domain containing protein, FIK; IsoId=Q8TF47-3; Sequence=VSP_057516, VSP_057517

Alternative Sequence

86..113; DWKTRPEVKSSHLQQDVSEVSHCTHDLL -> GFVCLLPLSLPSGSKGERRQKLPRKNPE (in isoform 2); 114..636; Missing (in isoform 2)

Domain & Motif Annotations

Zinc Finger

211..233; C2H2-type 1; 254..276; C2H2-type 2; 282..304; C2H2-type 3; 310..332; C2H2-type 4; 338..360; C2H2-type 5; 366..388; C2H2-type 6; 394..416; C2H2-type 7; 450..472; C2H2-type 8; 497..519; C2H2-type 9; 525..547; C2H2-type 10; 553..575; C2H2-type 11; 581..603; C2H2-type 12; 609..631; C2H2-type 13

Domain (FT)

14..85; KRAB

Protein Families

Krueppel C2H2-type zinc-finger protein family

Sequence Similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Clinical Relevance4

Antibody

HPA029017

Interaction Protein

ENSG00000130726

Interaction Count

Interaction Dataset

biogrid_opencell_bioplex

Supporting Publications2

PMID	Title	Abstract
38037300	Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.	No abstract available
38576002	Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation.	No abstract available