Protein detail
LRC15
Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by beta-amyloid homolog) (hLib)
Entry name LRC15 | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 5 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by beta-amyloid homolog) (hLib)
Protein Class (3)
Plasma proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Accessory Factors Involved in Transport
Transmembrane
539..559; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
LIB
Gene Description
Leucine rich repeat containing 15
Chromosome
3
Position
194355249-194369743
Supporting publications (n)
5
EVMP confidence score
0.28
Fluorescence & Localization
Cell SpecificEpicardial cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
Transporters:Accessory Factors Involved in Transport
Cellular Component (6)
Molecular Function (5)
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence21
Ligand-Receptor Signaling (20)
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | Yes | |||
| ecm | ecm | OmniPath | Yes | Yes | |||
| intracellular | intracellular | ComPPI | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes | ||||
| transmembrane_predicted | transmembrane | OmniPath | Yes | ||||
| transmembrane | transmembrane | OmniPath | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | Yes |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Data-Dependent Acquisition LC-MS/MS | 1 | 32795414 |
Sequence, Structure & Domains
Sequences
Length
581
Mass
64,366
Sequence
MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLAIAAIVIGIVALACSLAACVGCCCCKKRSQAVLMQMKAPNEC
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TF66-1; Sequence=Displayed; Name=2; IsoId=Q8TF66-2; Sequence=VSP_041130
Alternative Sequence
1; M -> MPLDKAM (in isoform 2)
Domain & Motif Annotations
Compositional Bias
499..509; Low complexity
Repeat
54..75; LRR 1; 78..99; LRR 2; 102..123; LRR 3; 126..147; LRR 4; 150..171; LRR 5; 174..195; LRR 6; 198..219; LRR 7; 222..243; LRR 8; 246..267; LRR 9; 270..291; LRR 10; 294..315; LRR 11; 318..339; LRR 12; 342..363; LRR 13; 366..387; LRR 14; 390..411; LRR 15
Domain (FT)
22..53; LRRNT; 423..475; LRRCT
Region
489..509; Disordered
Clinical Relevance
Antibody
Supporting Publications5
| PMID | Title | Related sentences |
|---|---|---|
| 33304478 | The proteomic landscape of small urinary extracellular vesicles during kidney transplantation. | No related sentences available |
| 33309826 | Proteomic analysis of extracellular vesicles and conditioned medium from human adipose-derived stem/stromal cells and dermal fibroblasts. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 40985879 | TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins. | No related sentences available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No related sentences available |