Protein detail

SHRM3

Protein Shroom3 (Shroom-related protein) (hShrmL)

Entry name SHRM3	UniProt ID Q8TF72	EVMP confidence score 0.38
Supporting publications (n)	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Protein Shroom3 (Shroom-related protein) (hShrmL)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000138771

Entrez Gene Symbol

SHROOM3

Gene Synonym (4)

APXL3KIAA1481SHRMShrmL

Gene Description

Shroom family member 3

Chromosome

Position

76435229-76783253

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecificintestineCell SpecificColonocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (6)

Molecular Function

GO:0051015 actin filament binding

Biological Process (3)

Canonical Pathways (3)

M5880 Naba ecm affiliated
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence12

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
apical_cell_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
SFN SHROOM3	P31947 Q8TF72	1:1	PDB	PDB:6fbbPDB:6fcp
RAB32 RAB38 SHROOM3	P57729 Q13637 Q8TF72	0:0:0	hu.MAPhu.MAP2
SAAL1 SHROOM3 SYNGAP1 USH1C	Q8TF72 Q96ER3 Q96PV0 Q9Y6N9	0:0:0:0	Havugimana2012	Havugimana2012:C_239

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	33893753

Sequence, Structure & Domains12

Sequences

Length

1,996

Mass

216,857

Sequence

MMRTTEDFHKPSATLNSNTATKGRYIYLEAFLEGGAPWGFTLKGGLEHGEPLIISKVEEGGKADTLSSKLQAGDEVVHINEVTLSSSRKEAVSLVKGSYKTLRLVVRRDVCTDPGHADTGASNFVSPEHLTSGPQHRKAAWSGGVKLRLKHRRSEPAGRPHSWHTTKSGEKQPDASMMQISQGMIGPPWHQSYHSSSSTSDLSNYDHAYLRRSPDQCSSQGSMESLEPSGAYPPCHLSPAKSTGSIDQLSHFHNKRDSAYSSFSTSSSILEYPHPGISGRERSGSMDNTSARGGLLEGMRQADIRYVKTVYDTRRGVSAEYEVNSSALLLQGREARASANGQGYDKWSNIPRGKGVPPPSWSQQCPSSLETATDNLPPKVGAPLPPARSDSYAAFRHRERPSSWSSLDQKRLCRPQANSLGSLKSPFIEEQLHTVLEKSPENSPPVKPKHNYTQKAQPGQPLLPTSIYPVPSLEPHFAQVPQPSVSSNGMLYPALAKESGYIAPQGACNKMATIDENGNQNGSGRPGFAFCQPLEHDLLSPVEKKPEATAKYVPSKVHFCSVPENEEDASLKRHLTPPQGNSPHSNERKSTHSNKPSSHPHSLKCPQAQAWQAGEDKRSSRLSEPWEGDFQEDHNANLWRRLEREGLGQSLSGNFGKTKSAFSSLQNIPESLRRHSSLELGRGTQEGYPGGRPTCAVNTKAEDPGRKAAPDLGSHLDRQVSYPRPEGRTGASASFNSTDPSPEEPPAPSHPHTSSLGRRGPGPGSASALQGFQYGKPHCSVLEKVSKFEQREQGSQRPSVGGSGFGHNYRPHRTVSTSSTSGNDFEETKAHIRFSESAEPLGNGEQHFKNGELKLEEASRQPCGQQLSGGASDSGRGPQRPDARLLRSQSTFQLSSEPEREPEWRDRPGSPESPLLDAPFSRAYRNSIKDAQSRVLGATSFRRRDLELGAPVASRSWRPRPSSAHVGLRSPEASASASPHTPRERHSVTPAEGDLARPVPPAARRGARRRLTPEQKKRSYSEPEKMNEVGIVEEAEPAPLGPQRNGMRFPESSVADRRRLFERDGKACSTLSLSGPELKQFQQSALADYIQRKTGKRPTSAAGCSLQEPGPLRERAQSAYLQPGPAALEGSGLASASSLSSLREPSLQPRREATLLPATVAETQQAPRDRSSSFAGGRRLGERRRGDLLSGANGGTRGTQRGDETPREPSSWGARAGKSMSAEDLLERSDVLAGPVHVRSRSSPATADKRQDVLLGQDSGFGLVKDPCYLAGPGSRSLSCSERGQEEMLPLFHHLTPRWGGSGCKAIGDSSVPSECPGTLDHQRQASRTPCPRPPLAGTQGLVTDTRAAPLTPIGTPLPSAIPSGYCSQDGQTGRQPLPPYTPAMMHRSNGHTLTQPPGPRGCEGDGPEHGVEEGTRKRVSLPQWPPPSRAKWAHAAREDSLPEESSAPDFANLKHYQKQQSLPSLCSTSDPDTPLGAPSTPGRISLRISESVLRDSPPPHEDYEDEVFVRDPHPKATSSPTFEPLPPPPPPPPSQETPVYSMDDFPPPPPHTVCEAQLDSEDPEGPRPSFNKLSKVTIARERHMPGAAHVVGSQTLASRLQTSIKGSEAESTPPSFMSVHAQLAGSLGGQPAPIQTQSLSHDPVSGTQGLEKKVSPDPQKSSEDIRTEALAKEIVHQDKSLADILDPDSRLKTTMDLMEGLFPRDVNLLKENSVKRKAIQRTVSSSGCEGKRNEDKEAVSMLVNCPAYYSVSAPKAELLNKIKEMPAEVNEEEEQADVNEKKAELIGSLTHKLETLQEAKGSLLTDIKLNNALGEEVEALISELCKPNEFDKYRMFIGDLDKVVNLLLSLSGRLARVENVLSGLGEDASNEERSSLYEKRKILAGQHEDARELKENLDRRERVVLGILANYLSEEQLQDYQHFVKMKSTLLIEQRKLDDKIKLGQEQVKCLLESLPSDFIPKAGALALPPNLTSEPIPAGGCTFSGIFPTLTSPL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TF72-1; Sequence=Displayed; Name=2; IsoId=Q8TF72-2; Sequence=VSP_024965, VSP_024966, VSP_024967, VSP_024968

Alternative Sequence

1..125; Missing (in isoform 2); 126..153; SPEHLTSGPQHRKAAWSGGVKLRLKHRR -> MAFYSTPEYDIQLARGLLSGMFLFATRR (in isoform 2); 277..311; ISGRERSGSMDNTSARGGLLEGMRQADIRYVKTVY -> KRVKTRDLPGSQSPGRAISRKTTMPTSGGGWREKA (in isoform 2); 312..1996; Missing (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

700..718; Basic and acidic residues; 750..768; Low complexity; 814..823; Polar residues; 826..836; Basic and acidic residues; 846..859; Basic and acidic residues; 862..871; Polar residues; 887..896; Polar residues; 897..909; Basic and acidic residues; 950..964; Low complexity; 1011..1027; Basic and acidic residues; 1137..1148; Low complexity; 1366..1375; Polar residues; 1403..1417; Basic and acidic residues; 1459..1472; Polar residues; 1498..1515; Basic and acidic residues; 1524..1536; Pro residues; 1634..1649; Polar residues; 1651..1665; Basic and acidic residues

Domain (CC)

The ASD1 domain mediates F-actin binding.; DOMAIN: The ASD2 domain mediates the interaction with ROCK1 and is required for apical constriction induction.

Domain (FT)

25..110; PDZ; 928..1030; ASD1; 1669..1957; ASD2

Region

150..173; Disordered; 340..389; Disordered; 437..468; Disordered; 568..629; Disordered; 673..772; Disordered; 788..1053; Disordered; 1093..1115; Disordered; 1137..1223; Disordered; 1315..1573; Disordered; 1627..1665; Disordered

Protein Families

Shroom family

Sequence Similarities

Belongs to the shroom family.

Clinical Relevance4

Antibody

HPA047784

Interaction Protein (5)

ENSG00000108953ENSG00000128245ENSG00000166913ENSG00000170027ENSG00000175793

Interaction Count

Interaction Dataset (2)

biogrid_opencellintact_biogrid