Protein detail
SHRM3
Protein Shroom3 (Shroom-related protein) (hShrmL)
Protein symbol SHRM3 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Protein Shroom3 (Shroom-related protein) (hShrmL)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
APXL3KIAA1481SHRMShrmL
Gene Description
Shroom family member 3
Chromosome
4
Position
76435229-76783253
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificintestineCell SpecificColonocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M5880 Naba ecm affiliated
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 33893753 |
Sequence, Structure & Domains
Sequences
Length
1,996
Mass
216,857
Sequence
MMRTTEDFHKPSATLNSNTATKGRYIYLEAFLEGGAPWGFTLKGGLEHGEPLIISKVEEGGKADTLSSKLQAGDEVVHINEVTLSSSRKEAVSLVKGSYKTLRLVVRRDVCTDPGHADTGASNFVSPEHLTSGPQHRKAAWSGGVKLRLKHRRSEPAGRPHSWHTTKSGEKQPDASMMQISQGMIGPPWHQSYHSSSSTSDLSNYDHAYLRRSPDQCSSQGSMESLEPSGAYPPCHLSPAKSTGSIDQLSHFHNKRDSAYSSFSTSSSILEYPHPGISGRERSGSMDNTSARGGLLEGMRQADIRYVKTVYDTRRGVSAEYEVNSSALLLQGREARASANGQGYDKWSNIPRGKGVPPPSWSQQCPSSLETATDNLPPKVGAPLPPARSDSYAAFRHRERPSSWSSLDQKRLCRPQANSLGSLKSPFIEEQLHTVLEKSPENSPPVKPKHNYTQKAQPGQPLLPTSIYPVPSLEPHFAQVPQPSVSSNGMLYPALAKESGYIAPQGACNKMATIDENGNQNGSGRPGFAFCQPLEHDLLSPVEKKPEATAKYVPSKVHFCSVPENEEDASLKRHLTPPQGNSPHSNERKSTHSNKPSSHPHSLKCPQAQAWQAGEDKRSSRLSEPWEGDFQEDHNANLWRRLEREGLGQSLSGNFGKTKSAFSSLQNIPESLRRHSSLELGRGTQEGYPGGRPTCAVNTKAEDPGRKAAPDLGSHLDRQVSYPRPEGRTGASASFNSTDPSPEEPPAPSHPHTSSLGRRGPGPGSASALQGFQYGKPHCSVLEKVSKFEQREQGSQRPSVGGSGFGHNYRPHRTVSTSSTSGNDFEETKAHIRFSESAEPLGNGEQHFKNGELKLEEASRQPCGQQLSGGASDSGRGPQRPDARLLRSQSTFQLSSEPEREPEWRDRPGSPESPLLDAPFSRAYRNSIKDAQSRVLGATSFRRRDLELGAPVASRSWRPRPSSAHVGLRSPEASASASPHTPRERHSVTPAEGDLARPVPPAARRGARRRLTPEQKKRSYSEPEKMNEVGIVEEAEPAPLGPQRNGMRFPESSVADRRRLFERDGKACSTLSLSGPELKQFQQSALADYIQRKTGKRPTSAAGCSLQEPGPLRERAQSAYLQPGPAALEGSGLASASSLSSLREPSLQPRREATLLPATVAETQQAPRDRSSSFAGGRRLGERRRGDLLSGANGGTRGTQRGDETPREPSSWGARAGKSMSAEDLLERSDVLAGPVHVRSRSSPATADKRQDVLLGQDSGFGLVKDPCYLAGPGSRSLSCSERGQEEMLPLFHHLTPRWGGSGCKAIGDSSVPSECPGTLDHQRQASRTPCPRPPLAGTQGLVTDTRAAPLTPIGTPLPSAIPSGYCSQDGQTGRQPLPPYTPAMMHRSNGHTLTQPPGPRGCEGDGPEHGVEEGTRKRVSLPQWPPPSRAKWAHAAREDSLPEESSAPDFANLKHYQKQQSLPSLCSTSDPDTPLGAPSTPGRISLRISESVLRDSPPPHEDYEDEVFVRDPHPKATSSPTFEPLPPPPPPPPSQETPVYSMDDFPPPPPHTVCEAQLDSEDPEGPRPSFNKLSKVTIARERHMPGAAHVVGSQTLASRLQTSIKGSEAESTPPSFMSVHAQLAGSLGGQPAPIQTQSLSHDPVSGTQGLEKKVSPDPQKSSEDIRTEALAKEIVHQDKSLADILDPDSRLKTTMDLMEGLFPRDVNLLKENSVKRKAIQRTVSSSGCEGKRNEDKEAVSMLVNCPAYYSVSAPKAELLNKIKEMPAEVNEEEEQADVNEKKAELIGSLTHKLETLQEAKGSLLTDIKLNNALGEEVEALISELCKPNEFDKYRMFIGDLDKVVNLLLSLSGRLARVENVLSGLGEDASNEERSSLYEKRKILAGQHEDARELKENLDRRERVVLGILANYLSEEQLQDYQHFVKMKSTLLIEQRKLDDKIKLGQEQVKCLLESLPSDFIPKAGALALPPNLTSEPIPAGGCTFSGIFPTLTSPL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TF72-1; Sequence=Displayed; Name=2; IsoId=Q8TF72-2; Sequence=VSP_024965, VSP_024966, VSP_024967, VSP_024968
Alternative Sequence
1..125; Missing (in isoform 2); 126..153; SPEHLTSGPQHRKAAWSGGVKLRLKHRR -> MAFYSTPEYDIQLARGLLSGMFLFATRR (in isoform 2); 277..311; ISGRERSGSMDNTSARGGLLEGMRQADIRYVKTVY -> KRVKTRDLPGSQSPGRAISRKTTMPTSGGGWREKA (in isoform 2); 312..1996; Missing (in isoform 2)
3D Structural Models
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
700..718; Basic and acidic residues; 750..768; Low complexity; 814..823; Polar residues; 826..836; Basic and acidic residues; 846..859; Basic and acidic residues; 862..871; Polar residues; 887..896; Polar residues; 897..909; Basic and acidic residues; 950..964; Low complexity; 1011..1027; Basic and acidic residues; 1137..1148; Low complexity; 1366..1375; Polar residues; 1403..1417; Basic and acidic residues; 1459..1472; Polar residues; 1498..1515; Basic and acidic residues; 1524..1536; Pro residues; 1634..1649; Polar residues; 1651..1665; Basic and acidic residues
Domain (CC)
The ASD1 domain mediates F-actin binding.; DOMAIN: The ASD2 domain mediates the interaction with ROCK1 and is required for apical constriction induction.
Domain (FT)
25..110; PDZ; 928..1030; ASD1; 1669..1957; ASD2
Region
150..173; Disordered; 340..389; Disordered; 437..468; Disordered; 568..629; Disordered; 673..772; Disordered; 788..1053; Disordered; 1093..1115; Disordered; 1137..1223; Disordered; 1315..1573; Disordered; 1627..1665; Disordered
Protein Families
Shroom family
Sequence Similarities
Belongs to the shroom family.
Clinical Relevance
Antibody
Interaction Protein
ENSG00000108953ENSG00000128245ENSG00000166913ENSG00000170027ENSG00000175793
Interaction Count
5
Interaction Dataset
biogrid_opencellintact_biogrid