Protein detail
SCRB1
Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36)
Protein symbol SCRB1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 2 | Protein classification Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36)
Protein Class
Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- Predicted intracellular proteins
Transmembrane
12..32; Helical; 444..464; Helical
Transmembrane Count
2
Ensembl
Entrez Gene Symbol
Gene Synonym
CD36L1CLA-1CLA1SR-BISRB1
Gene Description
Scavenger receptor class B member 1
Chromosome
12
Position
124776856-124882668
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- Transporters
- Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0001530 lipopolysaccharide binding
- GO:0001540 amyloid-beta binding
- GO:0001618 virus receptor activity
- GO:0001786 phosphatidylserine binding
- GO:0001875 lipopolysaccharide immune receptor activity
- GO:0005044 scavenger receptor activity
- GO:0005515 protein binding
- GO:0005545 1-phosphatidylinositol binding
- GO:0008035 high-density lipoprotein particle binding
- GO:0008289 lipid binding
- GO:0030169 low-density lipoprotein particle binding
- GO:0034185 apolipoprotein binding
- GO:0034186 apolipoprotein A-I binding
- GO:0070506 high-density lipoprotein particle receptor activity
Biological Process
KEGG
- hsa03272 Virion - Hepatitis viruses
- KEGG:hsa04145 Phagosome
- KEGG:hsa04913 Ovarian steroidogenesis
- KEGG:hsa04925 Aldosterone synthesis and secretion
- KEGG:hsa04927 Cortisol synthesis and secretion
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa04975 Fat digestion and absorption
- KEGG:hsa04976 Bile secretion
- KEGG:hsa04977 Vitamin digestion and absorption
- KEGG:hsa04979 Cholesterol metabolism
- KEGG:hsa05160 Hepatitis C
Reactome
- R-hsa-2173782 binding and uptake of ligands by scavenger receptors
- R-hsa-8964011 hdl clearance
- R-hsa-174824 plasma lipoprotein assembly remodeling and clearance
- R-hsa-8964043 plasma lipoprotein clearance
- R-hsa-3000471 scavenging by class b receptors
- R-hsa-382551 transport of small molecules
- R-hsa-5653656 vesicle mediated transport
Canonical Pathways
- M3468 Naba ecm regulators
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
| scavenger | receptor | Almen2009 | No | Yes | No | Yes | No |
| other_receptor_family | receptor | HPMR | No | Yes | No | Yes | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SCRB1 | Q8WTV0 | SRC | P12931 | Yes | Yes | No | SIGNOR | SIGNOR:26059978 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
552
Mass
60,878
Sequence
MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSHSLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLEGLGPSLGGGTGS
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=3; IsoId=Q8WTV0-1; Sequence=Displayed; Name=1; Synonyms=SR-BI; IsoId=Q8WTV0-2; Sequence=VSP_008554; Name=2; Synonyms=SR-BII; IsoId=Q8WTV0-3; Sequence=VSP_008553, VSP_008554; Name=4; Synonyms=SR-BIII; IsoId=Q8WTV0-4; Sequence=VSP_011037, VSP_008554; Name=5; Synonyms=SR-BI.2, SR-BII; IsoId=Q8WTV0-5; Sequence=VSP_054083
Alternative Sequence
1..42; MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLK -> MALQPSW (in isoform 4); 43..142; Missing (in isoform 2); 468..552; VGAGQRAARADSHSLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLEGLGPSLGGGTGS -> EKCYLFWSSSKKGSKDKEAIQAYSESLMTSAPKGSVLQEAKL (in isoform 1, isoform 2 and isoform 4); 468..552; VGAGQRAARADSHSLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLEGLGPSLGGGTGS -> GPEDTVSQPGLAAGPDRPPSPYTPLLPDSPSGQPPSPTA (in isoform 5)
3D Structural Models
Domain & Motif Annotations
Protein Families
CD36 family
Sequence Similarities
Belongs to the CD36 family.
Clinical Relevance
Interaction Protein
ENSG00000127022
Interaction Count
1
Interaction Dataset
biogrid_opencell