Protein detail

ABHD3

Phospholipase ABHD3 (EC 3.1.1.32) (EC 3.1.1.4) (Abhydrolase domain-containing protein 3)

Entry name ABHD3	UniProt ID Q8WU67	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification EnzymesPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Phospholipase ABHD3 (EC 3.1.1.32) (EC 3.1.1.4) (Abhydrolase domain-containing protein 3)

Protein Class (3)

EnzymesPredicted intracellular proteinsPredicted membrane proteins

Protein Function (3)

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Transmembrane

26..46; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000158201

Entrez Gene Symbol

ABHD3

Gene Synonym

LABH3

Gene Description

Abhydrolase domain containing 3, phospholipase

Chromosome

Position

21650901-21704780

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization7

Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificgdT-cellSecretome LocationSecreted - unknown locationSecretome FunctionImmunity

Function & Pathway6

Protein Function (3)

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Cellular Component (2)

Molecular Function (5)

Biological Process (3)

Reactome (4)

Mediation Categories

Metabolism mediation

Relations & Evidence9

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blotting	1	39569406

Sequence, Structure & Domains8

Sequences

Length

409

Mass

46,009

Sequence

MQRLAMDLRMLSRELSLYLEHQVRVGFFGSGVGLSLILGFSVAYAFYYLSSIAKKPQLVTGGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSKPPVQYRNELIKTADGGQISLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVAGENLLTPRTYCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDDYYTDASPSPRLKSVGIPVLCLNSVDDVFSPSHAIPIETAKQNPNVALVLTSYGGHIGFLEGIWPRQSTYMDRVFKQFVQAMVEHGHELS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WU67-1; Sequence=Displayed; Name=2; IsoId=Q8WU67-2; Sequence=VSP_056137, VSP_056138

Alternative Sequence

56..136; PQLVTGGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSKPPVQYRNELIKTADGGQISLDWFDNDNSTCYMDA -> RTTRRSGAGRVEDRPCLDLSSLRSPRCSTGMNLLKLQMEDRFHWTGLIMITVRVIWMPAPDLLSYCCLASREQARSHISFI (in isoform 2); 137..409; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)

140..233; AB hydrolase-1

Protein Families (2)

AB hydrolase superfamily
AB hydrolase 4 family

Sequence Similarities

Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

Clinical Relevance1

Antibody

HPA010729

Supporting Publications1

PMID	Title	Abstract
36114323	Blood plasma derived extracellular vesicles (BEVs): particle purification liquid chromatography (PPLC) and proteomic analysis reveals BEVs as a potential minimally invasive tool for predicting response to breast cancer treatment.	No abstract available