Protein detail
NEUFC
Neuferricin (Cytochrome b5 domain-containing protein 2)
Entry name NEUFC | UniProt ID | EVMP score 0.38 |
Frequency 4 | Transmembrane count | Protein classification Predicted intracellular proteinsPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Neuferricin (Cytochrome b5 domain-containing protein 2)
Protein Class
Predicted intracellular proteinsPredicted secreted proteins
Protein Function
- Predicted secreted proteins
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
MGC32124
Gene Description
Cytochrome b5 domain containing 2
Chromosome
17
Position
4143168-4187310
Frequency
4
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificErythrocyte progenitorsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- Predicted secreted proteins
- Predicted intracellular proteins
Molecular Function
Biological Process
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | Yes | Yes | No |
| ecm | ecm | OmniPath | Yes | No | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| intracellular | intracellular | ComPPI | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_location | No | No | Yes | Yes | No |
| secreted | secreted | HPA_secretome | No | No | Yes | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Western blottingFACSMass spectrometryAntibody array|Mass spectrometry [LTQ-FT Ultra] | 9 | 157907842052967221336773218197043638616337646133381037553825777238767348 |
Sequence, Structure & Domains
Sequences
Length
264
Mass
28,690
Sequence
MLRCGGRGLLLGLAVAAAAVMAARLMGWWGPRAGFRLFIPEELSRYRGGPGDPGLYLALLGRVYDVSSGRRHYEPGSHYSGFAGRDASRAFVTGDCSEAGLVDDVSDLSAAEMLTLHNWLSFYEKNYVCVGRVTGRFYGEDGLPTPALTQVEAAITRGLEANKLQLQEKQTFPPCNAEWSSARGSRLWCSQKSGGVSRDWIGVPRKLYKPGAKEPRCVCVRTTGPPSGQMPDNPPHRNRGDLDHPNLAEYTGCPPLAITCSFPL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WUJ1-1; Sequence=Displayed; Name=2; IsoId=Q8WUJ1-3; Sequence=VSP_045028
Alternative Sequence
1..112; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Domain (CC)
The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 73 and 106..
Domain (FT)
35..134; Cytochrome b5 heme-binding
Protein Families
- Cytochrome b5 family
- MAPR subfamily
Sequence Similarities
Belongs to the cytochrome b5 family. MAPR subfamily.