Protein detail

S20A1

Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1)

Entry name S20A1	UniProt ID Q8WUM9	EVMP confidence score 0.40
Supporting publications (n) 1	Transmembrane count 10	Protein classification Metabolic proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Sodium-dependent phosphate transporter 1 (Gibbon ape leukemia virus receptor 1) (GLVR-1) (Leukemia virus receptor 1 homolog) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1)

Protein Class (3)

Metabolic proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

21..41; Helical; 62..82; Helical; 100..120; Helical; 158..178; Helical; 203..223; Helical; 230..250; Helical; 511..531; Helical; 558..578; Helical; 600..620; Helical; 650..670; Helical

Transmembrane Count

Ensembl

ENSG00000144136

Entrez Gene Symbol

SLC20A1

Gene Synonym (4)

Glvr-1GLVR1PiT-1PiT1

Gene Description

Solute carrier family 20 member 1

Chromosome

Position

112645939-112663825

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBreast hormone-responsive cellsBlood Cell Specificnon-classical monocyte

Function & Pathway

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

Reactome (4)

Mediation Categories (3)

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence18

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SLC20A1	GSK3B	P49841	S	269	phosphorylation	KEA	KEA:17570479
SLC20A1	MAPK14	Q16539	S	269	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (14)

14 records.

Category	Parent	Database
transmembrane	transmembrane	OmniPath
plasma_membrane	plasma_membrane	UniProt_location
plasma_membrane	plasma_membrane	OmniPath
transmembrane	transmembrane_predicted	Phobius

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ATP13A1 GPAA1 PIGK PIGS PIGT SLC20A1 SV2A UBC	O43292 P0CG48 Q7L0J3 Q8WUM9 Q92643 Q969N2 Q96S52 Q9HD20	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8555

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	33893753

Sequence, Structure & Domains

Sequences

Length

679

Mass

73,700

Sequence

MATLITSTTAATAASGPLVDYLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILASIFETVGSVLLGAKVSETIRKGLIDVEMYNSTQGLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILHKADPVPNGLRALPVFYACTVGINLFSIMYTGAPLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREIKCSPSESPLMEKKNSLKEDHEETKLSVGDIENKHPVSEVGPATVPLQAVVEERTVSFKLGDLEEAPERERLPSVDLKEETSIDSTVNGAVQLPNGNLVQFSQAVSNQINSSGHYQYHTVHKDSGLYKELLHKLHLAKVGDCMGDSGDKPLRRNNSYTSYTMAICGMPLDSFRAKEGEQKGEEMEKLTWPNADSKKRIRMDSYTSYCNAVSDLHSASEIDMSVKAEMGLGDRKGSNGSLEEWYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYDTGDVSSKVATPIWLLLYGGVGICVGLWVWGRRVIQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAIFRYVILRM

Domain & Motif Annotations

Domain (CC)

Region A confers human cells susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection.

Region

550..558; A

Protein Families

Inorganic phosphate transporter (PiT) (TC 2.A.20) family

Sequence Similarities

Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.

Clinical Relevance

Antibody (3)

CAB019279 HPA035834 HPA064386

Supporting Publications1

PMID	Title	Related sentences
22329422	Quantitative proteome profiling of normal human circulating microparticles.	No related sentences available