Protein detail

CC107

Coiled-coil domain-containing protein 107

Protein symbol CC107	UniProt ID Q8WV48	EVMP score 0.50
Frequency 2	Transmembrane count 1	Protein classification

Basic Information

Protein Names

Coiled-coil domain-containing protein 107

Transmembrane

65..85; Helical

Transmembrane Count

Ensembl

ENSG00000159884

Entrez Gene Symbol

CCDC107

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Cellular Component

GO:0016020 membrane

Molecular Function

GO:0005515 protein binding

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	14	40985879 38207106 37926756 36064647 38113368 35119778 37322475 34064677 26826536 40189497 36146834 27821849 38207106 38716512

Sequence, Structure & Domains

Sequences

Length

283

Mass

30,509

Sequence

MAGAVSLLGVVGLLLVSALSGVLGDRANPDLRAHPGNAAHPGSGATEPRRRPPLKDQRERTRAGSLPLGALYTAAVAAFVLYKCLQGKDETAVLHEEASKQQPLQSEQQLAQLTQQLAQTEQHLNNLMAQLDPLFERVTTLAGAQQELLNMKLWTIHELLQDSKPDKDMEASEPGEGSGGESAGGGDKVSETGTFLISPHTEASRPLPEDFCLKEDEEEIGDSQAWEEPTNWSTETWNLATSWEVGRGLRRRCSQAVAKGPSHSLGWEGGTTAEGRLKQSLFS

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8WV48-1; Sequence=Displayed; Name=2; IsoId=Q8WV48-2; Sequence=VSP_024130, VSP_024133; Name=3; IsoId=Q8WV48-3; Sequence=VSP_024131, VSP_024132; Name=4; IsoId=Q8WV48-4; Sequence=VSP_024128, VSP_024129; Name=5; IsoId=Q8WV48-5; Sequence=VSP_042165

Alternative Sequence

107..119; EQQLAQLTQQLAQ -> GGFSRSLCWVGGV (in isoform 4); 120..283; Missing (in isoform 4); 138..155; VTTLAGAQQELLNMKLWT -> PAGASEHEAMDHPRAAAR (in isoform 2); 138..139; VT -> SF (in isoform 3); 140..283; Missing (in isoform 3); 156..283; Missing (in isoform 2); 175..201; Missing (in isoform 5)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

47..62; Basic and acidic residues; 176..187; Gly residues

Coiled Coil

104..134

Region

30..62; Disordered; 164..207; Disordered; 258..283; Disordered

Clinical Relevance