Protein detail
CANT1
Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog) (Putative MAPK-activating protein PM09) (Putative NF-kappa-B-activating protein 107)
Entry name CANT1 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Cancer-related genesDisease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog) (Putative MAPK-activating protein PM09) (Putative NF-kappa-B-activating protein 107)
Protein Class (8)
Cancer-related genesDisease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (7)
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Potential drug targets
- Enzymes
- ENZYME proteins:Hydrolases
- Cancer-related genes
- Disease related genes
Transmembrane
45..62; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
SCAN-1SHAPY
Gene Description
Calcium activated nucleotidase 1
Chromosome
17
Position
78991716-79009867
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization4
Tissue SpecificbrainCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificlower rhombic lip
Function & Pathway7
Protein Function (7)
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Potential drug targets
- Enzymes
- ENZYME proteins:Hydrolases
- Cancer-related genes
- Disease related genes
Cellular Component (10)
- GO:0005576 extracellular region
- GO:0005789 endoplasmic reticulum membrane
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0032580 Golgi cisterna membrane
- GO:0035580 specific granule lumen
- GO:0070062 extracellular exosome
- GO:1904724 tertiary granule lumen
- GO:1904813 ficolin-1-rich granule lumen
Molecular Function (6)
Biological Process (3)
KEGG (4)
Mediation Categories (2)
Immune mediationReceptor-signaling mediation
Relations & Evidence21
Ligand-Receptor Signaling (19)
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 33893753 |
Sequence, Structure & Domains11
Sequences
Length
401
Mass
44,840
Sequence
MPVQLSEHPEWNESMHSLRISVGGLPVLASMTKAADPRFRPRWKVILTFFVGAAILWLLCSHRPAPGRPPTHNAHNWRLGQAPANWYNDTYPLSPPQRTPAGIRYRIAVIADLDTESRAQEENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAEKGRGMELSDLIVFNGKLYSVDDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDVVNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPRRASQERYSEKDDERKGANLLLSASPDFGDIAVSHVGAVVPTHGFSSFKFIPNTDDQIIVALKSEEDSGRVASYIMAFTLDGRFLLPETKIGSVKYEGIEFI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8WVQ1-1; Sequence=Displayed; Name=2; IsoId=Q8WVQ1-2; Sequence=VSP_013760, VSP_013761; Name=3; IsoId=Q8WVQ1-3; Sequence=VSP_054260
Alternative Sequence
41..91; Missing (in isoform 3); 220..245; KDERLYVGGLGKEWTTTTGDVVNENP -> REIVRKRWRLVKQVSHVGVLGQWIQR (in isoform 2); 246..401; Missing (in isoform 2)
3D Structural Models
Turn
182..184; 204..207; 290..293
Helix
114..117; 244..246; 263..272; 309..312
Beta Strand
92..94; 97..99; 102..112; 125..137; 143..147; 152..157; 158..160; 167..173; 176..181; 186..191; 194..200; 208..211; 216..220; 223..227; 240..242; 247..251; 257..261; 280..282; 286..289; 294..297; 300..305; 319..323; 330..334; 342..349; 357..366; 369..378; 383..400
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Protein Families
Apyrase family
Sequence Similarities
Belongs to the apyrase family.
Clinical Relevance2
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 41216884 | Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation. | No abstract available |