Protein detail

DNJA4

DnaJ homolog subfamily A member 4

Entry name DNJA4	UniProt ID Q8WW22	EVMP confidence score 0.50
Supporting publications (n) 5	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

DnaJ homolog subfamily A member 4

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000140403

Entrez Gene Symbol

DNAJA4

Gene Synonym

PRO1472

Gene Description

DnaJ heat shock protein family (Hsp40) member A4

Chromosome

Position

78264086-78282196

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificAdipocytesSingle-Nuclei Brain Specificfibroblast

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function (6)

Reactome (2)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence5

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_SC_Cluster72	CPVL CTSA DNAJA1 DNAJA3 DNAJA4 DNAJB14 DNAJC3 DNAJC7 HSPA5 IDH1 IDH2	O75874 P10619 P11021 P31689 P48735 Q13217 Q8TBM8 Q8WW22 Q96EY1 Q99615 Q9H3G5	1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2279
	BAZ1A DNAJA4 H2AX HSPA1B LIG3 MRE11 RAD50 SUMO2 TCF7L2 TERF2IP XRCC5 XRCC6	P0DMV9 P12956 P13010 P16104 P49916 P49959 P61956 Q8WW22 Q92878 Q9NQB0 Q9NRL2 Q9NYB0	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5822

Sequence, Structure & Domains8

Sequences

Length

397

Mass

44,798

Sequence

MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGEKFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSPMDIFDMFFGGGGRMARERRGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGMQIHIQQIGPGMVQQIQTVCIECKGQGERINPKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDNRILVITSKAGEVIKHGDLRCVRDEGMPIYKAPLEKGILIIQFLVIFPEKHWLSLEKLPQLEALLPPRQKVRITDDMDQVELKEFCPNEQNWRQHREAYEEDEDGPQAGVQCQTA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8WW22-1; Sequence=Displayed; Name=2; IsoId=Q8WW22-2; Sequence=VSP_038965; Name=3; IsoId=Q8WW22-3; Sequence=VSP_045696

Alternative Sequence

1..44; MVKETQYYDILGVKPSASPEEIKKAYRKLALKYHPDKNPDEGEK -> MWESLTLDSGQISALTR (in isoform 3); 1; M -> MARGGSQSWSSGESDGQPKEQTPEKPRHKM (in isoform 2)

Domain & Motif Annotations

Repeat

135..142; CXXCXGXG motif; 151..158; CXXCXGXG motif; 178..185; CXXCXGXG motif; 194..201; CXXCXGXG motif

Zinc Finger

122..206; CR-type

Domain (FT)

4..70; J

Clinical Relevance4

Antibody (2)

CAB004646 HPA041790

Interaction Protein (2)

ENSG00000069345ENSG00000167136

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications5

PMID	Title	Abstract
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
38225453	Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.	No abstract available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available