Protein detail
TMM40
Transmembrane protein 40
Entry name TMM40 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 11 | Transmembrane count 2 | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Transmembrane protein 40
Protein Class
Predicted membrane proteins
Transmembrane
160..180; Helical; 187..207; Helical
Transmembrane Count
2
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ11036
Gene Description
Transmembrane protein 40
Chromosome
3
Position
12733528-12769457
Supporting publications (n)
11
EVMP confidence score
0.60
Fluorescence & Localization3
Tissue Specificadipose tissueCell SpecificAlveolar cells type 2Single-Nuclei Brain Specificcerebellar inhibitory
Function & Pathway4
Cellular Component
Molecular Function
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence9
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation；Acoustic trapping | Mass spectrometry | 1 | 27487081 |
Sequence, Structure & Domains7
Sequences
Length
233
Mass
25,495
Sequence
METSASSSQPQDNSQVHRETEDVDYGETDFHKQDGKAGLFSQEQYERNKSSSSSSSSSSSSSSSSSSSSSESNDEDQQPRATGKHRRSLGAGYPHGNGSPGPGHGEPDVLKDELQLYGDAPGEVVPSGESGLRRRGSDPASGEVEASQLRRLNIKKDDEFFHFVLLCFAIGALLVCYHYYADWFMSLGVGLLTFASLETVGIYFGLVYRIHSVLQGFIPLFQKFRLTGFRKTD
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8WWA1-1; Sequence=Displayed; Name=2; IsoId=Q8WWA1-2; Sequence=VSP_023643; Name=3; IsoId=Q8WWA1-3; Sequence=VSP_055682
Alternative Sequence
25..101; YGETDFHKQDGKAGLFSQEQYERNKSSSSSSSSSSSSSSSSSSSSSESNDEDQQPRATGKHRRSLGAGYPHGNGSPG -> C (in isoform 3); 71..100; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
1..14; Polar residues; 50..70; Low complexity; 93..104; Gly residues; 105..114; Basic and acidic residues
Region
1..143; Disordered
Clinical Relevance4
Supporting Publications11
| PMID | Title | Abstract |
|---|---|---|
| 29148239 | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | No abstract available |
| 31508500 | Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping. | No abstract available |
| 36398564 | Differential ultracentrifugation enables deep plasma proteomics through enrichment of extracellular vesicles. | No abstract available |
| 38225453 | Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions. | No abstract available |
| 38556629 | Differential effects of physiological agonists on the proteome of platelet-derived extracellular vesicles. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 39569406 | Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides. | No abstract available |
| 39766158 | A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis. | No abstract available |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No abstract available |
| 40545963 | Extracellular Vesicle Proteome Analysis Improves Diagnosis of Recurrence in Triple-Negative Breast Cancer. | No abstract available |
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