Protein detail
CTL1
Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92)
Entry name CTL1 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 31 | Transmembrane count 9 | Protein classification CD markersDisease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Choline transporter-like protein 1 (CDw92) (Solute carrier family 44 member 1) (CD antigen CD92)
Protein Class (6)
CD markersDisease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (4)
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- CD markers
- Potential drug targets
Transmembrane
31..51; Helical; 213..233; Helical; 239..259; Helical; 289..309; Helical; 316..336; Helical; 339..359; Helical; 381..401; Helical; 538..558; Helical; 567..587; Helical
Transmembrane Count
9
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
CD92CDW92CHTL1CTL1
Gene Description
Solute carrier family 44 member 1
Chromosome
9
Position
105244622-105439171
Supporting publications (n)
31
EVMP confidence score
0.63
Fluorescence & Localization1
Cell SpecificPodocytes
Function & Pathway7
Protein Function (4)
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- CD markers
- Potential drug targets
Cellular Component (7)
Molecular Function (3)
Biological Process (3)
Reactome (10)
- R-hsa-6798163 choline catabolism
- R-hsa-1483206 glycerophospholipid biosynthesis
- R-hsa-71291 metabolism of amino acids and derivatives
- R-hsa-556833 metabolism of lipids
- R-hsa-1483257 phospholipid metabolism
- R-hsa-9958517 slc mediated bile acid transport
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9955298 slc mediated transport of organic anions
- R-hsa-1483191 synthesis of pc
- R-hsa-382551 transport of small molecules
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence27
Ligand-Receptor Signaling (25)
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transporter | transporter | Surfaceome | No | Yes | No | Yes | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | Yes | No |
| slc44 | transporter | Surfaceome | No | Yes | No | Yes | No |
| slc | transporter | Surfaceome | No | Yes | No | Yes | No |
Page 1 of 3Next
Protein Complex Composition (1)
Sequence, Structure & Domains10
Sequences
Length
657
Mass
73,302
Sequence
MGCCSSASSAAQSSKREWKPLEDRSCTDIPWLLLFILFCIGMGFICGFSIATGAAARLVSGYDSYGNICGQKNTKLEAIPNSGMDHTQRKYVFFLDPCNLDLINRKIKSVALCVAACPRQELKTLSDVQKFAEINGSALCSYNLKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVNISCYAKFAEALITFVSDNSVLHRLISGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQRRSPKETVTPEQLQIAEDNLRALLIYAISATVFTVILFLIMLVMRKRVALTIALFHVAGKVFIHLPLLVFQPFWTFFALVLFWVYWIMTLLFLGTTGSPVQNEQGFVEFKISGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDKRNLPFTPILASVNRLIRYHLGTVAKGSFIITLVKIPRMILMYIHSQLKGKENACARCVLKSCICCLWCLEKCLNYLNQNAYTATAINSTNFCTSAKDAFVILVENALRVATINTVGDFMLFLGKVLIVCSTGLAGIMLLNYQQDYTVWVLPLIIVCLFAFLVAHCFLSIYEMVVDVLFLCFAIDTKYNDGSPGREFYMDKVLMEFVENSRKAMKEAGKGGVADSRELKPMASGASSA
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=A; IsoId=Q8WWI5-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q8WWI5-2; Sequence=VSP_015424, VSP_015425; Name=3; Synonyms=C; IsoId=Q8WWI5-3; Sequence=VSP_015426, VSP_015427
Alternative Sequence
651..654; ASGA -> LKKR (in isoform 2); 651..652; AS -> IK (in isoform 3); 653..657; Missing (in isoform 3); 655..657; Missing (in isoform 2)
3D Structural Models
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Compositional Bias
635..648; Basic and acidic residues
Region
635..657; Disordered
Protein Families
CTL (choline transporter-like) family
Sequence Similarities
Belongs to the CTL (choline transporter-like) family.
Supporting Publications31
| PMID | Title | Abstract |
|---|---|---|
| 39001700 | Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles. | No abstract available |
| 39290459 | Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease. | No abstract available |
| 39443544 | Profiling of urinary extracellular vesicle protein signatures from patients with cribriform and intraductal prostate carcinoma in a cross-sectional study. | No abstract available |
| 39873726 | Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer. | No abstract available |
| 39940785 | Secretome and Proteome of Extracellular Vesicles Provide Protein Markers of Lung and Colorectal Cancer. | No abstract available |
| 39949490 | CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro. | No abstract available |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |
| 40545963 | Extracellular Vesicle Proteome Analysis Improves Diagnosis of Recurrence in Triple-Negative Breast Cancer. | No abstract available |
| 40619995 | A 96-Well Ultrafiltration Approach for the High-Throughput Proteome Analysis of Extracellular Vesicles Isolated From Conditioned Medium. | No abstract available |