Protein detail
ICEF1
Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E)
Protein symbol ICEF1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA0403PIP3-E
Gene Description
Interaction protein for cytohesin exchange factors 1
Chromosome
6
Position
154154496-154356803
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain inhibitory neuronsSingle-Nuclei Brain Specificeccentric medium spiny neuronBlood Cell SpecificgdT-cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
437
Mass
48,993
Sequence
MTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDTPQELKKSPSSPSVENSI
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=IPCEF1-1; IsoId=Q8WWN9-1; Sequence=Displayed; Name=IPCEF1-2; IsoId=Q8WWN9-2; Sequence=VSP_032682; Name=CNK3-IPCEF1-1; Synonyms=CNK3/IPCEF1 Long-1; IsoId=G9CGD6-1; Sequence=External; Name=CNK3-IPCEF1-2; Synonyms=CNK3/IPCEF1 Long-2; IsoId=G9CGD6-2; Sequence=External; Name=CNK3-IPCEF1-3; Synonyms=CNK3/IPCEF1 Short; IsoId=G9CGD6-3; Sequence=External
Alternative Sequence
12; L -> LQ (in isoform IPCEF1-2)
3D Structural Models
Helix
125..138
Beta Strand
44..50; 63..70; 73..79; 86..90; 95..98; 102..104; 107..111; 117..121
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
151..162; Acidic residues; 172..200; Low complexity; 201..214; Polar residues; 273..283; Low complexity; 427..437; Polar residues
Domain (FT)
41..140; PH
Region
143..225; Disordered; 273..307; Disordered; 315..320; CRAC domain; 339..348; CRAC domain; 389..437; Required for interaction with CYTH2; 406..437; Disordered