Protein detail

ICEF1

Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E)

Entry name ICEF1	UniProt ID Q8WWN9	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000074706

Entrez Gene Symbol

IPCEF1

Gene Synonym (2)

KIAA0403PIP3-E

Gene Description

Interaction protein for cytohesin exchange factors 1

Chromosome

Position

154154496-154356803

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificbrainCell SpecificBrain inhibitory neuronsSingle-Nuclei Brain Specificeccentric medium spiny neuronBlood Cell SpecificgdT-cell

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence8

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	5	40189497 38113368 37322475 32854315 38207106

Sequence, Structure & Domains11

Sequences

Length

437

Mass

48,993

Sequence

MTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDTPQELKKSPSSPSVENSI

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=IPCEF1-1; IsoId=Q8WWN9-1; Sequence=Displayed; Name=IPCEF1-2; IsoId=Q8WWN9-2; Sequence=VSP_032682; Name=CNK3-IPCEF1-1; Synonyms=CNK3/IPCEF1 Long-1; IsoId=G9CGD6-1; Sequence=External; Name=CNK3-IPCEF1-2; Synonyms=CNK3/IPCEF1 Long-2; IsoId=G9CGD6-2; Sequence=External; Name=CNK3-IPCEF1-3; Synonyms=CNK3/IPCEF1 Short; IsoId=G9CGD6-3; Sequence=External

Alternative Sequence

12; L -> LQ (in isoform IPCEF1-2)

3D Structural Models

Helix

125..138

Beta Strand

44..50; 63..70; 73..79; 86..90; 95..98; 102..104; 107..111; 117..121

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

151..162; Acidic residues; 172..200; Low complexity; 201..214; Polar residues; 273..283; Low complexity; 427..437; Polar residues

Domain (FT)

41..140; PH

Region

143..225; Disordered; 273..307; Disordered; 315..320; CRAC domain; 339..348; CRAC domain; 389..437; Required for interaction with CYTH2; 406..437; Disordered

Clinical Relevance4

Antibody (2)

HPA028708 HPA028710

Interaction Protein (3)

ENSG00000100055ENSG00000105443ENSG00000108669

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available