Protein detail
S13A3
Na(+)/dicarboxylate cotransporter 3 (NaDC-3) (hNaDC3) (Na(+)-coupled carboxylate transporter 3) (NaC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) (Solute carrier family 13 member 3) (SLC13A3)
Entry name S13A3 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 12 | Transmembrane count 11 | Protein classification Disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Na(+)/dicarboxylate cotransporter 3 (NaDC-3) (hNaDC3) (Na(+)-coupled carboxylate transporter 3) (NaC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) (Solute carrier family 13 member 3) (SLC13A3)
Protein Class (5)
Disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (3)
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Potential drug targets
Transmembrane
15..33; Helical; Name=1; 36..54; Helical; Name=2; 59..72; Helical; Name=3; 78..120; Discontinuously helical; Name=4; 219..266; Discontinuously helical; Name=5; 275..334; Helical; Name=6; 340..357; Helical; Name=7; 378..390; Helical; Name=8; 418..459; Discontinuously helical; Name=9; 506..536; Discontinuously helical; Name=10; 541..571; Helical; Name=11
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
NADC3SDCT2
Gene Description
Solute carrier family 13 member 3
Chromosome
20
Position
46557823-46684467
Supporting publications (n)
12
EVMP confidence score
0.60
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neuronsSecretome LocationIntracellular and membraneSecretome FunctionBlood coagulation
Function & Pathway
Protein Function (3)
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Potential drug targets
Cellular Component (3)
Molecular Function (8)
- GO:0005310 dicarboxylic acid transmembrane transporter activity
- GO:0005515 protein binding
- GO:0015137 citrate transmembrane transporter activity
- GO:0015139 alpha-ketoglutarate transmembrane transporter activity
- GO:0015141 succinate transmembrane transporter activity
- GO:0015362 high-affinity sodium:dicarboxylate symporter activity
- GO:0017153 sodium:dicarboxylate symporter activity
- GO:0034634 glutathione transmembrane transporter activity
Biological Process (3)
Reactome (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence27
Ligand-Receptor Signaling (25)
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane | transmembrane | TopDB | |||||
| transmembrane | transmembrane | LOCATE | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| peripheral | peripheral | UniProt_topology | |||||
| peripheral | peripheral | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location |
Protein Complex Composition (1)
Sequence, Structure & Domains
Sequences
Length
602
Mass
66,841
Sequence
MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLFNPGFLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETEPLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTALPPTLANDTFRTL
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q8WWT9-1; Sequence=Displayed; Name=2; IsoId=Q8WWT9-2; Sequence=VSP_006123, VSP_006124; Name=3; IsoId=Q8WWT9-3; Sequence=VSP_015291, VSP_015293; Name=4; IsoId=Q8WWT9-4; Sequence=VSP_015292, VSP_015294, VSP_015295; Name=5; IsoId=Q8WWT9-5; Sequence=VSP_015292; Name=6; IsoId=Q8WWT9-6; Sequence=VSP_015291
Alternative Sequence
1..47; Missing (in isoform 3 and isoform 6); 181..297; AAVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLAGWLWI -> GIEPNTFLSEERLKLQAPLVIRLGQITESGQWNMSGNDVCNFRVLSFLPGGM (in isoform 2); 182..292; AVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLA -> KTTLGRQRFHWICRLTPGRRMNIVGTSGRASSSPSPTQPVLGAQPHSRAQPLTSSCLASSR (in isoform 4 and isoform 5); 298..602; Missing (in isoform 2); 340..374; Missing (in isoform 3); 375..388; FLSDAVTGVAIVTI -> CKMGIISISTIQKM (in isoform 4); 389..602; Missing (in isoform 4)
3D Structural Models
Turn
373..375; 389..391; 479..481; 524..526; 572..574; 578..580
Helix
2..13; 15..33; 36..54; 59..63; 65..72; 78..81; 83..86; 88..105; 108..120; 124..139; 144..163; 220..246; 250..252; 254..266; 275..300; 320..333; 340..357; 367..370; 378..388; 400..403; 418..424; 427..445; 448..455; 457..461; 464..478; 484..501; 506..516; 528..534; 541..565; 567..571
Beta Strand
247..249; 362..364; 392..395; 414..416
3D Structure
Electron microscopy (6)
Domain & Motif Annotations
Motif
143..145; SNT motif 1; 253..255; TXP motif; 483..485; SNT motif 2
Domain (CC)
The SNT motifs and TXP motif are essential for substrate recognition.
Protein Families (2)
- SLC13A/DASS transporter (TC 2.A.47) family
- NADC subfamily
Sequence Similarities
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
Clinical Relevance
Disease Involvement
Disease variant
Supporting Publications12
| PMID | Title | Related sentences |
|---|---|---|
| 25471207 | Intraluminal proteome and peptidome of human urinary extracellular vesicles. | No related sentences available |
| 30071318 | Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies. | No related sentences available |
| 32927759 | Urinary Exosomes of Patients with Cystic Fibrosis Unravel CFTR-Related Renal Disease. | No related sentences available |
| 34131392 | Could protein content of Urinary Extracellular Vesicles be useful to detect Cirrhosis in Alcoholic Liver Disease? | No related sentences available |
| 34341426 | Longitudinal stability of urinary extracellular vesicle protein patterns within and between individuals. | No related sentences available |
| 36635400 | Proteomic profiling of urinary small extracellular vesicles in children with pneumonia: a pilot study. | No related sentences available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No related sentences available |
| 37702715 | One-Pot Analytical Pipeline for Efficient and Sensitive Proteomic Analysis of Extracellular Vesicles. | No related sentences available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 39290459 | Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease. | No related sentences available |
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