Protein detail

S13A3

Na(+)/dicarboxylate cotransporter 3 (NaDC-3) (hNaDC3) (Na(+)-coupled carboxylate transporter 3) (NaC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) (Solute carrier family 13 member 3) (SLC13A3)

Entry name
S13A3
UniProt ID
Q8WWT9
EVMP confidence score
0.72
Supporting publications (n)
12
Transmembrane count
11
Protein classification
Disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information13
Protein Names
Na(+)/dicarboxylate cotransporter 3 (NaDC-3) (hNaDC3) (Na(+)-coupled carboxylate transporter 3) (NaC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) (Solute carrier family 13 member 3) (SLC13A3)
Protein Class (5)
Disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (3)
  • Transporters:Electrochemical Potential-driven transporters
  • Disease related genes
  • Potential drug targets
Transmembrane
15..33; Helical; Name=1; 36..54; Helical; Name=2; 59..72; Helical; Name=3; 78..120; Discontinuously helical; Name=4; 219..266; Discontinuously helical; Name=5; 275..334; Helical; Name=6; 340..357; Helical; Name=7; 378..390; Helical; Name=8; 418..459; Discontinuously helical; Name=9; 506..536; Discontinuously helical; Name=10; 541..571; Helical; Name=11
Transmembrane Count
11
Ensembl
ENSG00000158296
Entrez Gene Symbol
SLC13A3
Gene Synonym (2)
NADC3SDCT2
Gene Description
Solute carrier family 13 member 3
Chromosome
20
Position
46557823-46684467
Supporting publications (n)
12
EVMP confidence score
0.72
Fluorescence & Localization4
Tissue SpecificbrainCell SpecificBrain excitatory neuronsSecretome LocationIntracellular and membraneSecretome FunctionBlood coagulation
Function & Pathway6
Protein Function (3)
  • Transporters:Electrochemical Potential-driven transporters
  • Disease related genes
  • Potential drug targets
Cellular Component (3)
Molecular Function (8)
Biological Process (3)
Reactome (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence27

Ligand-Receptor Signaling (25)

25 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneUniProt_locationNoNoNoNoNo
transmembranetransmembraneUniProt_topologyNoNoNoNoNo
transmembranetransmembraneUniProt_keywordNoNoNoNoNo
transmembranetransmembraneTopDBNoNoNoNoNo
transmembranetransmembraneLOCATENoNoNoNoNo
transmembranetransmembraneRamilowski_locationNoNoNoNoNo
transmembranetransmembraneOmniPathNoNoNoNoNo
peripheralperipheralUniProt_topologyNoNoNoNoNo
peripheralperipheralOmniPathNoNoNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
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Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
SLC13A3Q8WWT92PDBPDB:8uvePDB:8uvfPDB:8uvgPDB:8uvdPDB:8uviPDB:8uvc

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometry9381133683511977837322475401894973256072336146834278218493820710638716512
Sequence, Structure & Domains13

Sequences

Length
602
Mass
66,841
Sequence
MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILKSLFGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFRGWRKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWASLFNPGFLSDAVTGVAIVTILFFFPSQRPSLKWWFDFKAPNTETEPLLTWKKAQETVPWNIILLLGGGFAMAKGCEESGLSVWIGGQLHPLENVPPALAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLRVHPLYLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWADMYSVNVTALPPTLANDTFRTL
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q8WWT9-1; Sequence=Displayed; Name=2; IsoId=Q8WWT9-2; Sequence=VSP_006123, VSP_006124; Name=3; IsoId=Q8WWT9-3; Sequence=VSP_015291, VSP_015293; Name=4; IsoId=Q8WWT9-4; Sequence=VSP_015292, VSP_015294, VSP_015295; Name=5; IsoId=Q8WWT9-5; Sequence=VSP_015292; Name=6; IsoId=Q8WWT9-6; Sequence=VSP_015291
Alternative Sequence
1..47; Missing (in isoform 3 and isoform 6); 181..297; AAVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLAGWLWI -> GIEPNTFLSEERLKLQAPLVIRLGQITESGQWNMSGNDVCNFRVLSFLPGGM (in isoform 2); 182..292; AVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLA -> KTTLGRQRFHWICRLTPGRRMNIVGTSGRASSSPSPTQPVLGAQPHSRAQPLTSSCLASSR (in isoform 4 and isoform 5); 298..602; Missing (in isoform 2); 340..374; Missing (in isoform 3); 375..388; FLSDAVTGVAIVTI -> CKMGIISISTIQKM (in isoform 4); 389..602; Missing (in isoform 4)

3D Structural Models

Turn
373..375; 389..391; 479..481; 524..526; 572..574; 578..580
Helix
2..13; 15..33; 36..54; 59..63; 65..72; 78..81; 83..86; 88..105; 108..120; 124..139; 144..163; 220..246; 250..252; 254..266; 275..300; 320..333; 340..357; 367..370; 378..388; 400..403; 418..424; 427..445; 448..455; 457..461; 464..478; 484..501; 506..516; 528..534; 541..565; 567..571
Beta Strand
247..249; 362..364; 392..395; 414..416
3D Structure
Electron microscopy (6)

Domain & Motif Annotations

Motif
143..145; SNT motif 1; 253..255; TXP motif; 483..485; SNT motif 2
Domain (CC)
The SNT motifs and TXP motif are essential for substrate recognition.
Protein Families (2)
  • SLC13A/DASS transporter (TC 2.A.47) family
  • NADC subfamily
Sequence Similarities
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
Clinical Relevance3
Disease Involvement
Disease variant
Drugs (2)
DOXORUBICIN HYDROCHLORIDEDAUNORUBICIN LIPOSOMAL
Antibody (3)
HPA014333HPA014353HPA014736
Supporting Publications12
PMIDTitleAbstract
25471207Intraluminal proteome and peptidome of human urinary extracellular vesicles.No abstract available
30071318Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies.No abstract available
32927759Urinary Exosomes of Patients with Cystic Fibrosis Unravel CFTR-Related Renal Disease.No abstract available
34131392Could protein content of Urinary Extracellular Vesicles be useful to detect Cirrhosis in Alcoholic Liver Disease?No abstract available
34341426Longitudinal stability of urinary extracellular vesicle protein patterns within and between individuals.No abstract available
36635400Proteomic profiling of urinary small extracellular vesicles in children with pneumonia: a pilot study.No abstract available
37686366Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.No abstract available
37702715One-Pot Analytical Pipeline for Efficient and Sensitive Proteomic Analysis of Extracellular Vesicles.No abstract available
38731868The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.No abstract available
39290459Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.No abstract available
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