Protein detail
CNKR2
Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2)
Entry name CNKR2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information6
Protein Names
Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2)
Protein Function (3)
- Disease related genes
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization3
Cell SpecificKupffer cellsBlood Cell Specificnon-classical monocyteBlood Lineage SpecificB-cells
Function & Pathway7
Protein Function (3)
- Disease related genes
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
Cellular Component (6)
Molecular Function (3)
Biological Process (3)
Reactome (7)
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-5674135 map2k and mapk activation
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-6802957 oncogenic mapk signaling
- R-hsa-6802952 signaling by braf and raf1 fusions
- R-hsa-6802946 signaling by moderate kinase activity braf mutants
Canonical Pathways
M68 Pid rhoa reg pathway
Mediation Categories (2)
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence8
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CNKR2 | Q8WXI2 | RAF1 | P04049 | Yes | Yes | No | SIGNORSignaLink3 | SignaLink3:23331499SIGNOR:14597674SignaLink3:14597674 |
Protein Complex Composition (2)
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CCNA1CCNE1CDC25ACDC6CDK1CDK2CDKN3CNKSR2FOXM1MOB3BORC1ORC2ORC3ORC5 | O43913P06493P24864P24941P30304P78396Q08050Q13415Q13416Q16667Q86TA1Q8WXI2Q99741Q9UBD5 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8429 | ||
| CCNA2CCNE1CDC25ACDK1CDK2CDK3CDKN3CKS1BCKS2CNKSR2MOB3BUBC | P06493P0CG48P20248P24864P24941P30304P33552P61024Q00526Q16667Q86TA1Q8WXI2 | 1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6313 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryMass spectrometry [LTQ-FT Ultra] | 1 | 27605433 |
Sequence, Structure & Domains13
Sequences
Length
1,034
Mass
117,535
Sequence
MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLAHTHSYIETHV
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=CNK2A, KSR2A; IsoId=Q8WXI2-1; Sequence=Displayed; Name=2; Synonyms=CNK2B, KSR2B; IsoId=Q8WXI2-2; Sequence=VSP_010887; Name=3; IsoId=Q8WXI2-4; Sequence=VSP_043168, VSP_010887; Name=4; IsoId=Q8WXI2-5; Sequence=VSP_043169
Alternative Sequence
271..319; Missing (in isoform 3); 435..464; Missing (in isoform 4); 899..1034; Missing (in isoform 2 and isoform 3)
3D Structural Models
Helix
8..10; 13..21; 25..30; 31..37; 41..45; 49..54; 60..77
3D Structure
NMR spectroscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
324..340; Low complexity; 545..559; Basic residues; 683..693; Acidic residues; 701..714; Pro residues; 730..740; Low complexity; 875..889; Acidic residues; 894..905; Basic and acidic residues
Coiled Coil
875..904
Domain (FT)
11..76; SAM; 84..178; CRIC; 215..297; PDZ; 332..515; DUF1170; 570..669; PH
Region
324..349; Disordered; 480..510; Disordered; 539..559; Disordered; 682..766; Disordered; 864..905; Disordered
Protein Families
CNKSR family
Sequence Similarities
Belongs to the CNKSR family.
Clinical Relevance3
Interaction Protein
ENSG00000146648
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 39940641 | Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients. | No abstract available |