Protein detail

CCG8

Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8)

Entry name CCG8	UniProt ID Q8WXS5	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 5	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8)

Protein Function (2)

FDA approved drug targets:Small molecule drugs
Transporters:Accessory Factors Involved in Transport

Transmembrane

19..39; Helical; 129..149; Helical; 158..178; Helical; 208..228; Helical; 318..338; Helical

Transmembrane Count

Ensembl

ENSG00000130433

Entrez Gene Symbol

CACNG6

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization1

Cell SpecificAstrocytes

Function & Pathway8

Protein Function (2)

FDA approved drug targets:Small molecule drugs
Transporters:Accessory Factors Involved in Transport

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

KEGG (7)

Reactome (4)

Canonical Pathways (3)

M3008 Naba ecm glycoproteins
M5884 Naba core matrisome
M5889 Naba matrisome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence20

Ligand-Receptor Signaling (19)

19 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transporter	transporter	Surfaceome	No	Yes	No	No	No
auxiliary_transport_unit	transporter	Almen2009	No	Yes	No	No	No
auxillarytransportunit	transporter	Surfaceome	No	Yes	No	No	No
cacng	transporter	Surfaceome	No	Yes	No	No	No
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No
voltage_gated_calcium	ion_channel	Almen2009	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Western BlottingMass SpectrometryFlow CytometryElisa	1	37087495

Sequence, Structure & Domains7

Sequences

Length

425

Mass

43,313

Sequence

MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRGGASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNRKTTPV

Domain & Motif Annotations

Compositional Bias

277..287; Low complexity; 343..354; Gly residues; 387..401; Pro residues; 412..425; Polar residues

Region

272..304; Disordered; 343..365; Disordered; 377..425; Disordered

Protein Families (2)

PMP-22/EMP/MP20 family
CACNG subfamily

Sequence Similarities

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Clinical Relevance1

Drugs (9)

PHLOROGLUCINOL GABAPENTIN ENACARBIL SULOCTIDIL IMAGABALIN ATAGABALIN BEPRIDIL HYDROCHLORIDE GABAPENTIN TERODILINE HYDROCHLORIDE PREGABALIN

Supporting Publications1

PMID	Title	Abstract
37651725	EPIC-1042 as a potent PTRF/Cavin1-caveolin-1 interaction inhibitor to induce PARP1 autophagic degradation and suppress temozolomide efflux for glioblastoma.	EPIC-1042 physically interrupted the interaction of PTRF/Cavin1 and caveolin-1, leading to reduced secretion of small extracellular vesicles (sEVs) to decrease TMZ efflux.