Protein detail
CCG8
Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8)
Protein symbol CCG8 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 5 | Protein classification |
Basic Information
Protein Names
Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8)
Protein Function
- FDA approved drug targets:Small molecule drugs
- Transporters:Accessory Factors Involved in Transport
Transmembrane
19..39; Helical; 129..149; Helical; 158..178; Helical; 208..228; Helical; 318..338; Helical
Transmembrane Count
5
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificAstrocytes
Function & Pathway
Protein Function
- FDA approved drug targets:Small molecule drugs
- Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04010 MAPK signaling pathway
- KEGG:hsa04260 Cardiac muscle contraction
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04921 Oxytocin signaling pathway
- KEGG:hsa05410 Hypertrophic cardiomyopathy
- KEGG:hsa05412 Arrhythmogenic right ventricular cardiomyopathy
- KEGG:hsa05414 Dilated cardiomyopathy
Reactome
Canonical Pathways
- M3008 Naba ecm glycoproteins
- M5884 Naba core matrisome
- M5889 Naba matrisome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| auxiliary_transport_unit | transporter | Almen2009 | No | Yes | No | No | No |
| auxillarytransportunit | transporter | Surfaceome | No | Yes | No | No | No |
| cacng | transporter | Surfaceome | No | Yes | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| voltage_gated_calcium | ion_channel | Almen2009 | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Western BlottingMass SpectrometryFlow CytometryElisa | 1 | 37087495 |
Sequence, Structure & Domains
Sequences
Length
425
Mass
43,313
Sequence
MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRGGASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNRKTTPV
3D Structural Models
Domain & Motif Annotations
Compositional Bias
277..287; Low complexity; 343..354; Gly residues; 387..401; Pro residues; 412..425; Polar residues
Region
272..304; Disordered; 343..365; Disordered; 377..425; Disordered
Protein Families
- PMP-22/EMP/MP20 family
- CACNG subfamily
Sequence Similarities
Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.