Protein detail

SORC1

VPS10 domain-containing receptor SorCS1 (hSorCS)

Entry name SORC1	UniProt ID Q8WY21	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 1	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

VPS10 domain-containing receptor SorCS1 (hSorCS)

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters

Transmembrane

1100..1120; Helical

Transmembrane Count

Ensembl

ENSG00000108018

Entrez Gene Symbol

SORCS1

Gene Description

Sortilin related VPS10 domain containing receptor 1

Chromosome

Position

106573663-107164706

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificastrocyte

Function & Pathway5

Protein Function

Transporters

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence26

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SORCS1	FURIN	P09958	R	110	cleavage	HPRD	HPRD:12482870

Ligand-Receptor Signaling (24)

24 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
vps10r	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryWestern blottingFlow cytometryMORPH	7	38441169 41315767 32795414 38731868 36362114 38107577 41216884

Sequence, Structure & Domains11

Sequences

Length

1,168

Mass

129,635

Sequence

MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQGRPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAERGEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNKRKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQLVKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEPCVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGIAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFVTTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAGNAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHILVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVLVHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGDSSLRLQRARHATPPSTPKRGSAGAQYAI

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=B; IsoId=Q8WY21-1; Sequence=Displayed; Name=2; IsoId=Q8WY21-2; Sequence=VSP_006204; Name=3; Synonyms=C; IsoId=Q8WY21-3; Sequence=VSP_015140; Name=4; Synonyms=A; IsoId=Q8WY21-4; Sequence=VSP_015141

Alternative Sequence

1125..1168; RVALPSPPSPSTQPGDSSLRLQRARHATPPSTPKRGSAGAQYAI -> KIPGINVYAQMQNEKEQEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIGSISIVAENQSTKEIPTYVNV (in isoform 2); 1125..1168; RVALPSPPSPSTQPGDSSLRLQRARHATPPSTPKRGSAGAQYAI -> KIPGINVYAQMQNEKEQEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIGK (in isoform 3); 1125..1168; RVALPSPPSPSTQPGDSSLRLQRARHATPPSTPKRGSAGAQYAI -> CVSLYPRSPTPDLFLLPDRFRSMCYSDVHSSDGFY (in isoform 4)

Domain & Motif Annotations

Compositional Bias

38..53; Low complexity; 111..123; Basic and acidic residues; 141..150; Basic and acidic residues

Repeat

208..219; BNR 1; 256..267; BNR 2; 492..503; BNR 3; 569..580; BNR 4; 611..622; BNR 5

Domain (FT)

161..794; Vps10p; 803..894; PKD

Region

38..69; Disordered; 89..150; Disordered; 161..665; 10-bladed beta-propeller; 673..721; 10CCa cysteine-knot; 723..794; 10CCb cysteine-knot; 1129..1168; Disordered

Protein Families (2)

VPS10-related sortilin family
SORCS subfamily

Sequence Similarities

Belongs to the VPS10-related sortilin family. SORCS subfamily.

Clinical Relevance1

Antibody

HPA011948

Supporting Publications4

PMID	Title	Abstract
32468033	Quantitative proteomic characterization of microvesicles/exosomes from the cerebrospinal fluid of patients with acute bilirubin encephalopathy.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available
41216884	Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation.	No abstract available