Protein detail
SORC1
VPS10 domain-containing receptor SorCS1 (hSorCS)
Protein symbol SORC1 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count 1 | Protein classification Predicted membrane proteinsTransporters |
Basic Information
Protein Names
VPS10 domain-containing receptor SorCS1 (hSorCS)
Protein Class
Predicted membrane proteinsTransporters
Protein Function
Transporters
Transmembrane
1100..1120; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Sortilin related VPS10 domain containing receptor 1
Chromosome
10
Position
106573663-107164706
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificesophagusCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
Transporters
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SORCS1 | FURIN | P09958 | R | 110 | cleavage | HPRD | HPRD:12482870 |
Ligand-Receptor Signaling
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
1,168
Mass
129,635
Sequence
MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQGRPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAERGEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNKRKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSAEFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFLANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGIIASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQLVKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEPCVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDGVREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDGIAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFVTTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAGNAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHILVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVLVHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGDSSLRLQRARHATPPSTPKRGSAGAQYAI
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=B; IsoId=Q8WY21-1; Sequence=Displayed; Name=2; IsoId=Q8WY21-2; Sequence=VSP_006204; Name=3; Synonyms=C; IsoId=Q8WY21-3; Sequence=VSP_015140; Name=4; Synonyms=A; IsoId=Q8WY21-4; Sequence=VSP_015141
Alternative Sequence
1125..1168; RVALPSPPSPSTQPGDSSLRLQRARHATPPSTPKRGSAGAQYAI -> KIPGINVYAQMQNEKEQEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIGSISIVAENQSTKEIPTYVNV (in isoform 2); 1125..1168; RVALPSPPSPSTQPGDSSLRLQRARHATPPSTPKRGSAGAQYAI -> KIPGINVYAQMQNEKEQEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIGK (in isoform 3); 1125..1168; RVALPSPPSPSTQPGDSSLRLQRARHATPPSTPKRGSAGAQYAI -> CVSLYPRSPTPDLFLLPDRFRSMCYSDVHSSDGFY (in isoform 4)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
38..53; Low complexity; 111..123; Basic and acidic residues; 141..150; Basic and acidic residues
Repeat
208..219; BNR 1; 256..267; BNR 2; 492..503; BNR 3; 569..580; BNR 4; 611..622; BNR 5
Domain (FT)
161..794; Vps10p; 803..894; PKD
Region
38..69; Disordered; 89..150; Disordered; 161..665; 10-bladed beta-propeller; 673..721; 10CCa cysteine-knot; 723..794; 10CCb cysteine-knot; 1129..1168; Disordered
Protein Families
- VPS10-related sortilin family
- SORCS subfamily
Sequence Similarities
Belongs to the VPS10-related sortilin family. SORCS subfamily.
Clinical Relevance
Antibody