Protein detail

CV015

Uncharacterized protein C22orf15 (Protein N27C7-3)

Entry name CV015	UniProt ID Q8WYQ4	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Uncharacterized protein C22orf15 (Protein N27C7-3)

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000169314

Entrez Gene Symbol

C22orf15

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Cell SpecificEndometrial glandular cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell Specificnon-classical monocyteBlood Lineage Specificmonocytes

Function & Pathway4

Protein Function

Predicted intracellular proteins

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence3

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
secreted	secreted	HPA_secretome	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	16	40985879 40189497 37926756 36064647 38113368 40465195 37322475 33592500 41307968 33309826 40840701 31805958 38207106 34576246 37204515 39207047

Sequence, Structure & Domains7

Sequences

Length

148

Mass

16,487

Sequence

MFIKVMFGAGCSVLVNTSCRLVNLTAHLRQKAGLPPDATIALLAEDGNLVSLEEDLKEGASRAQTMGNSLLKERAIYVLVRIIKGEDMASTRYESLLENLDDHYPELAEELRRLSGLSSVGHNWRKRMGTRRGRHEQSPTSRPRKGPD

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WYQ4-1; Sequence=Displayed; Name=2; IsoId=Q8WYQ4-2; Sequence=VSP_014462, VSP_014463

Alternative Sequence

84; K -> SKVAQE (in isoform 2); 109..148; EELRRLSGLSSVGHNWRKRMGTRRGRHEQSPTSRPRKGPD -> GANRQQPSRTPLAESGIAEKLHQQEGQGP (in isoform 2)

Domain & Motif Annotations

Compositional Bias

123..134; Basic residues

Region

122..148; Disordered

Supporting Publications3

PMID	Title	Abstract
33304478	The proteomic landscape of small urinary extracellular vesicles during kidney transplantation.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available