Protein detail

KLHL6

Kelch-like protein 6

Protein symbol KLHL6	UniProt ID Q8WZ60	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Kelch-like protein 6

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000172578

Entrez Gene Symbol

KLHL6

Gene Synonym

FLJ00029

Gene Description

Kelch like family member 6

Chromosome

Position

183487551-183555706

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificHematopoietic stem cells

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Canonical Pathways

M236 Pid delta np63 pathway

Mediation Categories

Immune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KLHL6	Q8WZ60	CDK2	P24941	Yes	No	Yes	SIGNOR	SIGNOR:29720484

Protein Complex Composition

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CRL3 E3 ubiquitin ligase complexKLHL6 variant	CUL3 KLHL6 RBX1	P62877 Q13618 Q8WZ60	2:2:2	ComplexPortal	intact:EBI-44455167	35580799 29249570 16166635 24959344 14755292
	KLHL6 KLHL7 MSRB3 RBP4	P02753 Q8IXL7 Q8IXQ5 Q8WZ60	0:0:0:0	hu.MAP2
	DCUN1D4 KLHL6 KLHL7 MSRB3 RBP4	P02753 Q8IXL7 Q8IXQ5 Q8WZ60 Q92564	0:0:0:0:0	hu.MAP2
	DAZL KLHL6 PRRC2A R3HDM2 RC3H1 RC3H2	P48634 Q5TC82 Q8WZ60 Q92904 Q9HBD1 Q9Y2K5	0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingELISA	6	38731868 24505114 28242843 37686366 40098346 31588238

Sequence, Structure & Domains

Sequences

Length

621

Mass

70,359

Sequence

MLMAGQRGAWTMGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIRKSYTHIRRIVPGAVSV

3D Structural Models

Domain & Motif Annotations

Repeat

320..367; Kelch 1; 378..421; Kelch 2; 422..468; Kelch 3; 470..516; Kelch 4; 517..558; Kelch 5; 560..606; Kelch 6

Domain (FT)

72..139; BTB; 174..276; BACK

Clinical Relevance

Antibody

HPA024512