Protein detail
KLHL6
Kelch-like protein 6
Entry name KLHL6 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Kelch-like protein 6
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ00029
Gene Description
Kelch like family member 6
Chromosome
3
Position
183487551-183555706
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization2
Cell SpecificHematopoietic stem cells
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (2)
Molecular Function (2)
Biological Process (3)
Canonical Pathways
M236 Pid delta np63 pathway
Mediation Categories
Immune mediation
Relations & Evidence9
Ligand-Receptor Signaling (3)
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KLHL6 | Q8WZ60 | CDK2 | P24941 | Yes | No | Yes | SIGNOR | SIGNOR:29720484 |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CRL3 E3 ubiquitin ligase complexKLHL6 variant | CUL3KLHL6RBX1 | P62877Q13618Q8WZ60 | 2:2:2 | ComplexPortal | intact:EBI-44455167 | 3558079929249570161666352495934414755292 |
| KLHL6KLHL7MSRB3RBP4 | P02753Q8IXL7Q8IXQ5Q8WZ60 | 0:0:0:0 | hu.MAP2 | |||
| DCUN1D4KLHL6KLHL7MSRB3RBP4 | P02753Q8IXL7Q8IXQ5Q8WZ60Q92564 | 0:0:0:0:0 | hu.MAP2 | |||
| DAZLKLHL6PRRC2AR3HDM2RC3H1RC3H2 | P48634Q5TC82Q8WZ60Q92904Q9HBD1Q9Y2K5 | 0:0:0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
Sequence, Structure & Domains5
Sequences
Length
621
Mass
70,359
Sequence
MLMAGQRGAWTMGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIRKSYTHIRRIVPGAVSV
Domain & Motif Annotations
Repeat
320..367; Kelch 1; 378..421; Kelch 2; 422..468; Kelch 3; 470..516; Kelch 4; 517..558; Kelch 5; 560..606; Kelch 6
Domain (FT)
72..139; BTB; 174..276; BACK
Clinical Relevance1
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38278418 | Density-based lipoprotein depletion improves extracellular vesicle isolation and functional analysis. | No abstract available |