Protein detail
AQP3
Aquaporin-3 (AQP-3) (Aquaglyceroporin-3)
Entry name AQP3 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count 6 | Protein classification Blood group antigen proteinsMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Aquaporin-3 (AQP-3) (Aquaglyceroporin-3)
Protein Class (5)
Blood group antigen proteinsMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function (2)
- Blood group antigen proteins
- Transporters:Transporter channels and pores
Transmembrane
25..42; Helical; Name=1; 57..74; Helical; Name=2; 101..121; Helical; Name=3; 160..177; Helical; Name=4; 190..206; Helical; Name=5; 243..264; Helical; Name=6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
GIL
Gene Description
Aquaporin 3 (Gill blood group)
Chromosome
9
Position
33441156-33447596
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization4
Cell SpecificKupffer cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificneutrophil
Function & Pathway7
Protein Function (2)
- Blood group antigen proteins
- Transporters:Transporter channels and pores
Cellular Component (6)
Molecular Function (5)
Biological Process (3)
Reactome (7)
- R-hsa-445717 aquaporin mediated transport
- R-hsa-9734767 developmental cell lineages
- R-hsa-9734779 developmental cell lineages of the integumentary system
- R-hsa-9725554 differentiation of keratinocytes in interfollicular epidermis in mammalian skin
- R-hsa-432047 passive transport by aquaporins
- R-hsa-382551 transport of small molecules
- R-hsa-432040 vasopressin regulates renal water homeostasis via aquaporins
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence28
Ligand-Receptor Signaling (27)
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| basolateral_cell_membrane | plasma_membrane | Ramilowski_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | Ramilowski_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | LOCATE | No | No | No | No | No |
| plasma_membrane | plasma_membrane | LOCATE | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry | 13 | 39766158363985643778691834817906289865852859009030646616309501853994804038321535320897432914823933709510 |
Sequence, Structure & Domains9
Sequences
Length
292
Mass
31,544
Sequence
MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92482-1; Sequence=Displayed; Name=2; Synonyms=delta5; IsoId=Q92482-2; Sequence=VSP_003229, VSP_003230
Alternative Sequence
165..281; FIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENV -> DRPALVVGAHRVPTPGLHCGCLRVPADDRLPPGAAPTLQRGRECEAGPCEAQGADLSGKGHLPLRCPGLEHPLTVQGHSQEAPLHDPPFQAKELPIYPHPTKTAPSGFPLDLAQIAP (in isoform 2); 282..292; Missing (in isoform 2)
Domain & Motif Annotations
Motif
83..85; NPA 1; 215..217; NPA 2
Domain (CC)
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Protein Families
MIP/aquaporin (TC 1.A.8) family
Sequence Similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Clinical Relevance2
Drugs (48)
[SAR9,MET(O2)11]SPROLAPITANTR116031CP 99994L-732,138APREPITANTR-486VOFOPITANTSUBSTANCE P-(6-11)NETUPITANTEZLOPITANTFK-888CASOPITANTFOSAPREPITANTLANEPITANTSCH 206272SUBSTANCE P-OMEL760735ZD6021TAK-637PHYSALAEMINL-703,606SAREDUTANTRP67580SERLOPITANTNEUROPEPTIDE-&GAMMAVESTIPITANTOSANETANTNEUROKININ BNEUROKININ ABEFETUPITANTELEDOISIN[125I]SP (HUMAN, MOUSE, RAT)[125I]L703,606TRADIPITANTSUBSTANCE PIMNOPITANTNEUROPEPTIDE KSUBSTANCE P-(4-11)[18F]SPA-RQNOLPITANTIUMHEMOKININ 1FK 224KASSININPHYLLOMEDUSIN[3H]SP (HUMAN, MOUSE, RAT)SEPTIDET2328
Antibody
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 31805958 | Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment. | No abstract available |
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |