Protein detail
YLAT2
Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)
Entry name YLAT2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)
Protein Class (4)
Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Transmembrane
45..65; Helical; 79..99; Helical; 115..135; Helical; 168..188; Helical; 195..215; Helical; 236..256; Helical; 267..287; Helical; 312..332; Helical; 364..384; Helical; 386..406; Helical; 426..446; Helical; 452..472; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
KIAA0245LAT-2LAT3y+LAT-2
Gene Description
Solute carrier family 7 member 6
Chromosome
16
Position
68264516-68301823
Supporting publications (n)
1
EVMP confidence score
0.38
Function & Pathway6
Protein Function (2)
- Transporters:Electrochemical Potential-driven transporters
- Predicted intracellular proteins
Cellular Component
Molecular Function (7)
- GO:0005515 protein binding
- GO:0015171 amino acid transmembrane transporter activity
- GO:0015174 basic amino acid transmembrane transporter activity
- GO:0015179 L-amino acid transmembrane transporter activity
- GO:0034618 arginine binding
- GO:0061459 L-arginine transmembrane transporter activity
- GO:0106439 L-lysine:L-arginine antiporter activity
Biological Process (3)
Reactome (6)
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence31
Ligand-Receptor Signaling (24)
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | DGIdb | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| slc7 | transporter | Surfaceome | No | Yes | No | No | No |
| apc | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
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Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AAR2EAPPECDGHDCNCDNSLC7A6OSTSSC4ZNHIT2 | O95905Q56P03Q8N2G8Q96CW6Q9UBB6Q9UHR6Q9Y312Q9Y5U2 | 0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| AAR2EAPPECDGHDCSLC7A6OSTSSC4ZNHIT2 | O95905Q56P03Q8N2G8Q96CW6Q9UHR6Q9Y312Q9Y5U2 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| AAR2EAPPECDNCDNSLC7A6OSTSSC4ZNHIT2 | O95905Q56P03Q96CW6Q9UBB6Q9UHR6Q9Y312Q9Y5U2 | 0:0:0:0:0:0:0 | hu.MAP | |||
| AAR2EAPPECDNCDNSLC7A6OSTSSC4 | O95905Q56P03Q96CW6Q9UBB6Q9Y312Q9Y5U2 | 0:0:0:0:0:0 | hu.MAP | |||
| AAR2EAPPECDSLC7A6OSTSSC4ZNHIT2 | O95905Q56P03Q96CW6Q9UHR6Q9Y312Q9Y5U2 | 0:0:0:0:0:0 | hu.MAP | |||
| SLC7A6OSTSSC4 | Q96CW6Q9Y5U2 | 0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 33919183 |
Sequence, Structure & Domains7
Sequences
Length
515
Mass
56,828
Sequence
MEAREPGRPTPTYHLVPNTSQSQVEEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVWAIGGLFSVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIAITFANYIIQPSFPSCDPPYLACRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIAIIVMGLVKLCQGHSEHFQDAFEGSSWDMGNLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPKRPRPLKLSVFFPIVFCICSVFLVIVPLFTDTINSLIGIGIALSGVPFYFMGVYLPESRRPLFIRNVLAAITRGTQQLCFCVLTELDVAEEKKDERKTD
3D Structural Models
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Region
1..36; Disordered
Protein Families (2)
- Amino acid-polyamine-organocation (APC) superfamily
- L-type amino acid transporter (LAT) (TC 2.A.3.8) family
Sequence Similarities
Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
Clinical Relevance4
Antibody
Interaction Protein
ENSG00000168003
Interaction Count
1
Interaction Dataset
biogrid_opencell
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |