Protein detail

YLAT2

Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)

Entry name YLAT2	UniProt ID Q92536	EVMP confidence score 0.40
Supporting publications (n) 1	Transmembrane count 12	Protein classification Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)

Protein Class (4)

Metabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (2)

Transporters:Electrochemical Potential-driven transporters
Predicted intracellular proteins

Transmembrane

45..65; Helical; 79..99; Helical; 115..135; Helical; 168..188; Helical; 195..215; Helical; 236..256; Helical; 267..287; Helical; 312..332; Helical; 364..384; Helical; 386..406; Helical; 426..446; Helical; 452..472; Helical

Transmembrane Count

Ensembl

ENSG00000103064

Entrez Gene Symbol

SLC7A6

Gene Synonym (4)

KIAA0245LAT-2LAT3y+LAT-2

Gene Description

Solute carrier family 7 member 6

Chromosome

Position

68264516-68301823

Supporting publications (n)

EVMP confidence score

0.40

Function & Pathway

Protein Function (2)

Transporters:Electrochemical Potential-driven transporters
Predicted intracellular proteins

Cellular Component

GO:0005886 plasma membrane

Molecular Function (7)

Biological Process (3)

Reactome (6)

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence31

Ligand-Receptor Signaling (24)

24 records.

Category	Parent	Database	Receiver
cell_surface	cell_surface	Surfaceome
cell_surface	cell_surface	OmniPath
receptor	receptor	scConnect	Yes
transmembrane	transmembrane_predicted	Phobius

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Protein Complex Composition (6)

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
AAR2 EAPP ECD GHDC NCDN SLC7A6OS TSSC4 ZNHIT2	O95905 Q56P03 Q8N2G8 Q96CW6 Q9UBB6 Q9UHR6 Q9Y312 Q9Y5U2	0:0:0:0:0:0:0:0	hu.MAP2
AAR2 EAPP ECD GHDC SLC7A6OS TSSC4 ZNHIT2	O95905 Q56P03 Q8N2G8 Q96CW6 Q9UHR6 Q9Y312 Q9Y5U2	0:0:0:0:0:0:0	hu.MAP2
AAR2 EAPP ECD NCDN SLC7A6OS TSSC4 ZNHIT2	O95905 Q56P03 Q96CW6 Q9UBB6 Q9UHR6 Q9Y312 Q9Y5U2	0:0:0:0:0:0:0	hu.MAP
AAR2 EAPP ECD NCDN SLC7A6OS TSSC4	O95905 Q56P03 Q96CW6 Q9UBB6 Q9Y312 Q9Y5U2	0:0:0:0:0:0	hu.MAP
AAR2 EAPP ECD SLC7A6OS TSSC4 ZNHIT2	O95905 Q56P03 Q96CW6 Q9UHR6 Q9Y312 Q9Y5U2	0:0:0:0:0:0	hu.MAP
SLC7A6OS TSSC4	Q96CW6 Q9Y5U2	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	33919183

Sequence, Structure & Domains

Sequences

Length

515

Mass

56,828

Sequence

MEAREPGRPTPTYHLVPNTSQSQVEEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVWAIGGLFSVVGALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIAITFANYIIQPSFPSCDPPYLACRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIAIIVMGLVKLCQGHSEHFQDAFEGSSWDMGNLSLALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPKRPRPLKLSVFFPIVFCICSVFLVIVPLFTDTINSLIGIGIALSGVPFYFMGVYLPESRRPLFIRNVLAAITRGTQQLCFCVLTELDVAEEKKDERKTD

3D Structural Models

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Region

1..36; Disordered

Protein Families (2)

Amino acid-polyamine-organocation (APC) superfamily
L-type amino acid transporter (LAT) (TC 2.A.3.8) family

Sequence Similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.

Clinical Relevance

Antibody

HPA050713

Interaction Protein

ENSG00000168003

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications1

PMID	Title	Related sentences
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No related sentences available