Protein detail

SL9A6

Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Solute carrier family 9 member 6)

Entry name SL9A6	UniProt ID Q92581	EVMP confidence score 0.38
Supporting publications (n) 5	Transmembrane count 12	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Solute carrier family 9 member 6)

Protein Class (6)

Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (5)

Predicted intracellular proteins
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Transmembrane

71..91; Helical; Name=1; 103..123; Helical; Name=2; 176..196; Helical; Name=3; 211..231; Helical; Name=4; 252..272; Helical; Name=5; 278..298; Helical; Name=6; 324..344; Helical; Name=7; 372..392; Helical; Name=8; 414..434; Helical; Name=9; 436..456; Helical; Name=10; 479..499; Helical; Name=11; 515..535; Helical; Name=12

Transmembrane Count

Ensembl

ENSG00000198689

Entrez Gene Symbol

SLC9A6

Gene Synonym (3)

KIAA0267NHE-6NHE6

Gene Description

Solute carrier family 9 member A6

Chromosome

Position

135973841-136047269

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue Specificbone marrowCell SpecificCytotrophoblastsBlood Cell SpecificT-regBlood Lineage Specificgranulocytes

Function & Pathway8

Protein Function (5)

Predicted intracellular proteins
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Cellular Component (7)

Molecular Function (4)

Biological Process (3)

KEGG

hsa04260 Cardiac muscle contraction

Reactome (6)

Canonical Pathways (3)

M86 Pid arf6 pathway
M67 Pid arf6 trafficking pathway
M92 Pid angiopoietin receptor pathway

Mediation Categories (2)

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence26

Ligand-Receptor Signaling (24)

24 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
slc9	transporter	Surfaceome	No	Yes	No	No	No
slc	transporter	Surfaceome	No	Yes	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ELOVL4 ELOVL5 GPAA1 PIGK PIGS PIGT SEC11A SLC9A6 UBC	O43292 P0CG48 P67812 Q92581 Q92643 Q969N2 Q96S52 Q9GZR5 Q9NYP7	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6808

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	30550287

Sequence, Structure & Domains7

Sequences

Length

701

Mass

77,917

Sequence

MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=2; Synonyms=NHE6.1, NHE6v1; IsoId=Q92581-2; Sequence=Displayed; Name=1; Synonyms=NHE6.0; IsoId=Q92581-1; Sequence=VSP_061774; Name=3; IsoId=Q92581-3; Sequence=VSP_044868

Alternative Sequence

1..52; Missing (in isoform 3); 144..175; Missing (in isoform 1)

Domain & Motif Annotations

Protein Families

Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

Sequence Similarities

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

Clinical Relevance6

Disease Involvement (3)

Disease variantEpilepsyIntellectual disability

Drug Targets (3)

Literature-reported targetClinical trial targetSuccessful target

Antibody (2)

HPA059445 HPA059590

Interaction Protein

ENSG00000127022

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications5

PMID	Title	Abstract
25776846	Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens.	No abstract available
29603567	Involvement of serum-derived exosomes of elderly patients with bone loss in failure of bone remodeling via alteration of exosomal bone-related proteins.	No abstract available
30865381	Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114.	No abstract available
31753726	Serum extracellular vesicles contain SPARC and LRG1 as biomarkers of colon cancer and differ by tumour primary location.	No abstract available
41167904	Accessing the proteome of extracellular vesicles via rapid acoustic isolation of a minute human blood plasma sample.	No abstract available