Protein detail
SORL
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
Protein symbol SORL | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsPredicted secreted proteinsTransporters |
Basic Information
Protein Names
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
Protein Class
Disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function
- Disease related genes
- Predicted secreted proteins
- Transporters
- Potential drug targets
Transmembrane
2138..2158; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
C11orf32gp250LR11LRP9SorLASorLA-1
Gene Description
Sortilin related receptor 1
Chromosome
11
Position
121452314-121633763
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificesophagusCell SpecificEnteric stem cells
Function & Pathway
Protein Function
- Disease related genes
- Predicted secreted proteins
- Transporters
- Potential drug targets
Cellular Component
- GO:0000139 Golgi membrane
- GO:0005615 extracellular space
- GO:0005641 nuclear envelope lumen
- GO:0005768 endosome
- GO:0005769 early endosome
- GO:0005771 multivesicular body
- GO:0005783 endoplasmic reticulum
- GO:0005789 endoplasmic reticulum membrane
- GO:0005794 Golgi apparatus
- GO:0005802 trans-Golgi network
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0010008 endosome membrane
- GO:0016020 membrane
- GO:0030658 transport vesicle membrane
- GO:0031901 early endosome membrane
- GO:0031985 Golgi cisterna
- GO:0032585 multivesicular body membrane
- GO:0043025 neuronal cell body
- GO:0055037 recycling endosome
- GO:0055038 recycling endosome membrane
- GO:0070062 extracellular exosome
- GO:0097356 perinucleolar compartment
Molecular Function
- GO:0001540 amyloid-beta binding
- GO:0004888 transmembrane signaling receptor activity
- GO:0005041 low-density lipoprotein particle receptor activity
- GO:0005515 protein binding
- GO:0019828 aspartic-type endopeptidase inhibitor activity
- GO:0030169 low-density lipoprotein particle binding
- GO:0031267 small GTPase binding
- GO:0042923 neuropeptide binding
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SORL1 | ROCK2 | O75116 | S | 2,206 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPProtMapperdbPTMREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | dbPTM:21147781ProtMapper:22621900ProtMapper:23264752 |
Ligand-Receptor Signaling
37 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | HPMR | No | No | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| intracellular | intracellular | ComPPI | No | No | Yes | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | Yes | Yes | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| APOE | P02649 | SORL | Q92673 | Yes | Yes | No | HPMRFantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020HINTBaccin2019Ramilowski2015_Baccin2019CellinkerWangLRdbEMBRACEHPMR_talklr | Baccin2019:11294867LRdb:11294867SIGNOR:11557679CellTalkDB:11294867HPMR:11294867HINT:11294867HPMR:11557679HINT:17326667Cellinker:11294867connectomeDB2020:11294867 |
| ROCK2 | O75116 | SORL | Q92673 | Yes | No | No | Sparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetProtMapperdbPTMREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:22621900ProtMapper:23264752ProtMapper:31892243PhosphoSite:21147781dbPTM:21147781PhosphoSite:20015111 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
2,214
Mass
248,426
Sequence
MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGASRADEKPLRRKRSAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKQENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTNTVLKVLKPDTTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGVIVGHWAPPIHTHGLIREYIVEYSRSGSKMWASQRAASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSITTIKGKVIPPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQTAVECTWTGPRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVVVPYQGPSSDYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAVAVKDLIRKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKHFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQARCLFGNQICGEPAILLYDELGSGADASATQAARSTDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA
3D Structural Models
Turn
256..258; 397..400; 604..607; 638..641; 740..745
Helix
149..151; 287..289; 366..368; 402..405; 435..437; 469..471; 480..485; 544..546; 618..621; 627..629; 635..637; 679..681; 694..696; 703..705
Beta Strand
48..51; 91..98; 103..109; 117..122; 125..128; 133..140; 145..147; 164..169; 177..192; 198..201; 207..211; 219..223; 230..236; 242..253; 264..268; 271..273; 275..282; 290..298; 300..303; 306..313; 318..320; 323..330; 333..337; 349..353; 355..358; 360..363; 369..374; 377..379; 383..391; 394..396; 407..409; 411..416; 420..422; 424..428; 431..434; 439..445; 451..453; 460..462; 473..479; 488..490; 492..495; 498..500; 504..510; 512..514; 519..525; 528..530; 531..536; 538..543; 548..553; 560..566; 572..575; 577..579; 581..588; 590..592; 596..602; 610..616; 630..633; 647..654; 670..674; 682..684; 688..690; 699..701; 722..724; 727..730; 748..750; 1655..1660; 1669..1674; 1683..1692; 1699..1710; 1718..1729; 1731..1734; 1738..1741
3D Structure
Electron microscopy (1); NMR spectroscopy (1); X-ray crystallography (5)
Domain & Motif Annotations
Repeat
136..147; BNR 1; 232..243; BNR 2; 441..452; BNR 3; 521..532; BNR 4; 562..573; BNR 5; 800..843; LDL-receptor class B 1; 844..887; LDL-receptor class B 2; 888..932; LDL-receptor class B 3; 933..970; LDL-receptor class B 4; 971..1013; LDL-receptor class B 5
Motif
63..65; Cell attachment site; 2161..2164; Potential nuclear localization signal for the C-terminal fragment generated by PSEN1; 2172..2177; Endocytosis signal; 2208..2212; DXXLL motif involved in the interaction with GGA1
Domain (FT)
91..754; Vps10p; 1026..1072; EGF-like; 1076..1114; LDL-receptor class A 1; 1115..1155; LDL-receptor class A 2; 1156..1194; LDL-receptor class A 3; 1198..1236; LDL-receptor class A 4; 1238..1272; LDL-receptor class A 5; 1273..1317; LDL-receptor class A 6; 1323..1361; LDL-receptor class A 7; 1366..1405; LDL-receptor class A 8; 1417..1455; LDL-receptor class A 9; 1469..1508; LDL-receptor class A 10; 1512..1551; LDL-receptor class A 11; 1557..1649; Fibronectin type-III 1; 1653..1745; Fibronectin type-III 2; 1749..1844; Fibronectin type-III 3; 1843..1927; Fibronectin type-III 4; 1934..2029; Fibronectin type-III 5; 2030..2118; Fibronectin type-III 6
Region
91..617; 10-bladed beta-propeller; 625..675; 10CCa cysteine-knot; 677..754; 10CCb cysteine-knot; 2190..2214; Required for efficient Golgi apparatus - endosome sorting; 2201..2214; Required for interaction with GGA1 and GGA2
Protein Families
- VPS10-related sortilin family
- SORL1 subfamily
Sequence Similarities
Belongs to the VPS10-related sortilin family. SORL1 subfamily.