Protein detail
RSCA1
Regulatory solute carrier protein family 1 member 1 (Transporter regulator RS1) (hRS1)
Entry name RSCA1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Regulatory solute carrier protein family 1 member 1 (Transporter regulator RS1) (hRS1)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
RS1
Gene Description
Regulator of solute carriers 1
Chromosome
1
Position
15659713-15662033
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificNeutrophilsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted to bloodSecretome FunctionEnzyme
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| RSC1A1 | PRKCA | P17252 | S | 366 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | DGIdb | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DDI2RSC1A1SARM1ZG16BZNF423ZNF521 | Q2M1K9Q5TDH0Q6SZW1Q92681Q96DA0Q96K83 | 0:0:0:0:0:0 | hu.MAP2 | |||
| RSC1A1SARM1ZG16BZNF423 | Q2M1K9Q6SZW1Q92681Q96DA0 | 0:0:0:0 | hu.MAP2 | |||
| RSC1A1SARM1ZG16BZNF423ZNF521 | Q2M1K9Q6SZW1Q92681Q96DA0Q96K83 | 0:0:0:0:0 | hu.MAP2 | |||
| RSC1A1ZG16BZNF423 | Q2M1K9Q92681Q96DA0 | 0:0:0 | hu.MAP2 | |||
| RSC1A1ZG16BZNF423ZNF521 | Q2M1K9Q92681Q96DA0Q96K83 | 0:0:0:0 | hu.MAP2 | |||
| DDI1NRIP3RSC1A1 | Q8WTU0Q92681Q9NQ35 | 0:0:0 | hu.MAP | |||
| RSC1A1ZG16B | Q92681Q96DA0 | 0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry | 12 | 397661583778691839940923348179062932070428986585278941043064661630950185383215353956940633709510 |
Sequence, Structure & Domains
Sequences
Length
617
Mass
66,790
Sequence
MSSLPTSDGFNHPARSSGQSPDVGNPMSLARSVSASVCPIKPSDSDRIEPKAVKALKASAEFQLNSEKKEHLSLQDLSDHASSADHAPTDQSPAMPMQNSSEEITVAGNLEKSAERSTQGLKFHLHTRQEASLSVTSTRMHEPQMFLGEKDWHPENQNLSQVSDPQQHEEPGNEQYEVAQQKASHDQEYLCNIGDLELPEERQQNQHKIVDLEATMKGNGLPQNVDPPSAKKSIPSSECSGCSNSETFMEIDTAQQSLVTLLNSTGRQNANVKNIGALDLTLDNPLMEVETSKCNPSSEILNDSISTQDLQPPETNVEIPGTNKEYGHYSSPSLCGSCQPSVESAEESCPSITAALKELHELLVVSSKPASENTSEEVICQSETIAEGQTSIKDLSERWTQNEHLTQNEQCPQVSFHQAISVSVETEKLTGTSSDTGREAVENVNFRSLGDGLSTDKEGVPKSRESINKNRSVTVTSAKTSNQLHCTLGVEISPKLLAGEEDALNQTSEQTKSLSSNFILVKDLGQGIQNSVTDRPETRENVCPDASRPLLEYEPPTSHPSSSPAILPPLIFPATDIDRILRAGFTLQEALGALHRVGGNADLALLVLLAKNIVVPT
3D Structural Models
Domain & Motif Annotations
Compositional Bias
1..22; Polar residues; 43..52; Basic and acidic residues; 66..83; Basic and acidic residues; 89..103; Polar residues; 155..165; Polar residues
Domain (CC)
The tripeptides QCP and QSP mediate post-transcriptional down-regulation of SLC5A1 at the trans-Golgi network. They inhibit a monosaccharide-dependent exocytotic pathway of SLC5A1..
Domain (FT)
571..611; UBA
Region
1..106; Disordered; 155..181; Disordered; 217..237; Disordered; 410..412; Involved in post-transcriptional down-regulation of SLC5A1