Protein detail

NECT2

Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)

Protein symbol NECT2	UniProt ID Q92692	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)

Protein Class

CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

CD markers
Predicted intracellular proteins

Transmembrane

361..381; Helical

Transmembrane Count

Ensembl

ENSG00000130202

Entrez Gene Symbol

NECTIN2

Gene Synonym

CD112HVEBNectin-2PRR2PVRL2PVRR2

Gene Description

Nectin cell adhesion molecule 2

Chromosome

Position

44846175-44889223

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificlungCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmyeloid DCBlood Lineage SpecificB-cells

Function & Pathway

Protein Function

CD markers
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
NECTIN2	SRC	P12931	Y	505	phosphorylation	KEASIGNOR	KEA:10962558 SIGNOR:10962558

Ligand-Receptor Signaling

72 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	Baccin2019	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
nectin	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	MCAM	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	No	Yes	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SRC	P12931	NECT2	Q92692	Yes	No	No	SIGNORProtMapperphosphoELM_KEAKEASIGNOR_ProtMapper	KEA:10962558 SIGNOR:10962558 ProtMapper:10962558
NECT2	Q92692	CD226	Q15762	Yes	Yes	No	CellChatDBCellPhoneDBUniProt_LRdbICELLNETSIGNORconnectomeDB2020HPRDHINTBaccin2019Lit-BM-17WangLRdb	HPRD:15536144 Lit-BM-17:12913096 connectomeDB2020:15607800 HINT:21982860 ICELLNET:27192565 HINT:12913096 SIGNOR:15039383 Lit-BM-17:21982860 HPRD:12913096

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	NECTIN2	Q92692	2	PDB	PDB:4dfhPDB:4hza

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blottingR SequencingFlow cytometry	2	38731868 38490958

Sequence, Structure & Domains

Sequences

Length

538

Mass

57,742

Sequence

MARAAALLPSRSPPTPLLWPLLLLLLLETGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIPVPPGPPAVEDVSLDLEDEEGEEEEEYLDKINPIYDALSYSSPSDSYQGKGFVMSRAMYV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=Delta; IsoId=Q92692-1; Sequence=Displayed; Name=Alpha; IsoId=Q92692-2; Sequence=VSP_002628, VSP_002629

Alternative Sequence

351..479; NTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIP -> RASPRDVGPLVWGAVGGTLLVLLLLAGGSLAFILLRVRRRRKSPGGAGGGASGDGGFYDPKAQVLGNGDPVFWTPVVPGPMEPDGKDEEEEEEEEKAEKGLMLPPPPALEDDMESQLDGSLISRRAVYV (in isoform Alpha); 480..538; Missing (in isoform Alpha)

3D Structural Models

Turn

87..89; 113..115

Helix

77..79; 100..102; 132..134

Beta Strand

35..37; 40..43; 50..52; 55..58; 64..71; 73..75; 81..86; 90..92; 95..98; 103..107; 125..127; 136..145; 148..157

3D Structure

X-ray crystallography (7)

Domain & Motif Annotations

Domain (FT)

32..156; Ig-like V-type; 162..256; Ig-like C2-type 1; 261..345; Ig-like C2-type 2

Region

390..414; Disordered; 462..489; Disordered

Protein Families

Nectin family

Sequence Similarities

Belongs to the nectin family.

Clinical Relevance

Antibody

HPA012374 HPA012759 CAB026138

Interaction Protein

ENSG00000101152ENSG00000130396ENSG00000177707

Interaction Count

Interaction Dataset

intact_biogrid