Protein detail

NECT2

Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)

Protein symbol NECT2	UniProt ID Q92692	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)

Protein Class

CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

CD markers
Predicted intracellular proteins

Transmembrane

361..381; Helical

Transmembrane Count

Ensembl

ENSG00000130202

Entrez Gene Symbol

NECTIN2

Gene Synonym

CD112HVEBNectin-2PRR2PVRL2PVRR2

Gene Description

Nectin cell adhesion molecule 2

Chromosome

Position

44846175-44889223

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificlungCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmyeloid DCBlood Lineage SpecificB-cells

Function & Pathway

Protein Function

CD markers
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
NECTIN2	SRC	P12931	Y	505	phosphorylation	KEASIGNOR	KEA:10962558 SIGNOR:10962558

Ligand-Receptor Signaling

72 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	Baccin2019	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
ligand	ligand	CellCall	Yes	No	No	Yes	No
ligand	ligand	GO_Intercell	Yes	No	No	Yes	No
ligand	ligand	ICELLNET	Yes	No	No	Yes	No
ligand	ligand	LRdb	Yes	No	No	Yes	No
checkpoint	ligand	ICELLNET	Yes	No	No	Yes	No
checkpoint_nectin	ligand	ICELLNET	Yes	No	No	Yes	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SRC	P12931	NECT2	Q92692	Yes	No	No	SIGNORProtMapperphosphoELM_KEAKEASIGNOR_ProtMapper	KEA:10962558 SIGNOR:10962558 ProtMapper:10962558
NECT2	Q92692	CD226	Q15762	Yes	Yes	No	CellChatDBCellPhoneDBUniProt_LRdbICELLNETSIGNORconnectomeDB2020HPRDHINTBaccin2019Lit-BM-17WangLRdb	HPRD:15536144 Lit-BM-17:12913096 connectomeDB2020:15607800 HINT:21982860 ICELLNET:27192565 HINT:12913096 SIGNOR:15039383 Lit-BM-17:21982860 HPRD:12913096

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	NECTIN2	Q92692	2	PDB	PDB:4dfhPDB:4hza

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blottingR SequencingFlow cytometry	2	38731868 38490958

Sequence, Structure & Domains

Sequences

Length

538

Mass

57,742

Sequence

MARAAALLPSRSPPTPLLWPLLLLLLLETGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIPVPPGPPAVEDVSLDLEDEEGEEEEEYLDKINPIYDALSYSSPSDSYQGKGFVMSRAMYV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=Delta; IsoId=Q92692-1; Sequence=Displayed; Name=Alpha; IsoId=Q92692-2; Sequence=VSP_002628, VSP_002629

Alternative Sequence

351..479; NTAGAGATGGIIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIP -> RASPRDVGPLVWGAVGGTLLVLLLLAGGSLAFILLRVRRRRKSPGGAGGGASGDGGFYDPKAQVLGNGDPVFWTPVVPGPMEPDGKDEEEEEEEEKAEKGLMLPPPPALEDDMESQLDGSLISRRAVYV (in isoform Alpha); 480..538; Missing (in isoform Alpha)

3D Structural Models

Turn

87..89; 113..115

Helix

77..79; 100..102; 132..134

Beta Strand

35..37; 40..43; 50..52; 55..58; 64..71; 73..75; 81..86; 90..92; 95..98; 103..107; 125..127; 136..145; 148..157

3D Structure

X-ray crystallography (7)

Domain & Motif Annotations

Domain (FT)

32..156; Ig-like V-type; 162..256; Ig-like C2-type 1; 261..345; Ig-like C2-type 2

Region

390..414; Disordered; 462..489; Disordered

Protein Families

Nectin family

Sequence Similarities

Belongs to the nectin family.

Clinical Relevance

Antibody

HPA012374 HPA012759 CAB026138

Interaction Protein

ENSG00000101152ENSG00000130396ENSG00000177707

Interaction Count

Interaction Dataset

intact_biogrid