Protein detail
HTRA1
Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (L56) (Serine protease 11)
Entry name HTRA1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (L56) (Serine protease 11)
Protein Class
Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteins
Protein Function
- Predicted intracellular proteins
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Enzymes
- Peptidases:Serine-type peptidases
- Predicted secreted proteins
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Ensembl
Entrez Gene Symbol
Gene Synonym
ARMD7HtrAIGFBP5-proteasePRSS11
Gene Description
HtrA serine peptidase 1
Chromosome
10
Position
122458551-122514907
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Enzymes
- Peptidases:Serine-type peptidases
- Predicted secreted proteins
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
M8626 Sig bcr signaling pathway
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | HPA_secretome | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster346 | CRYAAHTRA1HTRA2HTRA3HTRA4 | O43464P02489P83105P83110Q92743 | 1:1:1:1:1 | Compleat | Compleat:HC2310 | 22036573 |
| HTRA1REG4SPINK4 | O60575Q92743Q9BYZ8 | 0:0:0 | hu.MAP2 | |||
| CES3HTRA1HTRA3TMEM25 | P83110Q6UWW8Q86YD3Q92743 | 0:0:0:0 | hu.MAP | |||
| HTRA1 | Q92743 | 3 | PDB | PDB:3nwuPDB:3tjnPDB:8sdpPDB:6z0xPDB:6z0ePDB:8sdmPDB:8se8PDB:8se7PDB:7sjnPDB:7sjoPDB:6z0yPDB:3tjo |
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
480
Mass
51,287
Sequence
MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
3D Structural Models
Turn
180..182; 193..195; 211..213; 219..221; 247..250
Helix
43..45; 129..141; 165..168; 172..179; 270..272; 304..306; 325..327; 357..369; 392..401; 422..426; 445..454
Beta Strand
57..59; 65..68; 74..77; 87..90; 108..113; 118..123; 125..128; 183..191; 198..208; 214..217; 224..231; 233..235; 237..246; 251..255; 278..282; 285..288; 292..297; 301..303; 319..321; 328..333; 339..348; 351..356; 380..382; 384..389; 411..417; 419..421; 433..437; 456..464; 467..473; 476..478
3D Structure
Electron microscopy (2); NMR spectroscopy (2); X-ray crystallography (14)
Domain & Motif Annotations
Domain (CC)
The IGFBP N-terminal domain mediates interaction with TSC2 substrate.
Domain (FT)
33..113; IGFBP N-terminal; 98..157; Kazal-like; 365..467; PDZ
Region
204..364; Serine protease
Protein Families
Peptidase S1C family
Sequence Similarities
Belongs to the peptidase S1C family.
Clinical Relevance
Disease Involvement
Age-related macular degenerationDisease variant
Antibody