Protein detail

NRCAM

Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)

Protein symbol NRCAM	UniProt ID Q92823	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification Disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)

Protein Class

Disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteins

Protein Function

Disease related genes
Predicted secreted proteins

Transmembrane

1168..1190; Helical

Transmembrane Count

Ensembl

ENSG00000091129

Entrez Gene Symbol

NRCAM

Gene Synonym

BravoKIAA0343

Gene Description

Neuronal cell adhesion molecule

Chromosome

Position

108147623-108456717

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificadipose tissueCell SpecificBrain inhibitory neuronsSingle-Nuclei Brain Specificeccentric medium spiny neuronBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Disease related genes
Predicted secreted proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
NRCAM	EPHB2	P29323	Y	1,276	phosphorylation	SIGNOR	SIGNOR:24023801
NRCAM	EPHB1	P54762	Y	1,276	phosphorylation	SIGNOR	SIGNOR:24023801

Ligand-Receptor Signaling

53 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	ICELLNET	No	Yes	Yes	Yes	No
receptor	receptor	CellChatDB	No	Yes	Yes	Yes	No
receptor	receptor	CellTalkDB	No	Yes	Yes	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	Yes	Yes	No
receptor	receptor	LRdb	No	Yes	Yes	Yes	No
cell_adhesion	receptor	ICELLNET	No	Yes	Yes	Yes	No
receptor	receptor	OmniPath	No	Yes	Yes	Yes	No
ecm	ecm	MatrixDB	Yes	No	Yes	Yes	No
ecm	ecm	OmniPath	Yes	No	Yes	Yes	No
extracellular	extracellular	DGIdb	No	No	Yes	Yes	No

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Regulatory Interaction Network

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NRCAM	Q92823	ANK1	P16157	Yes	Yes	No	WangCui2007SIGNORCA1	SIGNOR:7961622 CA1:7961622
NRCAM	Q92823	ANK3	Q12955	Yes	Yes	No	SIGNOR	SIGNOR:7961622
EPHB1	P54762	NRCAM	Q92823	Yes	Yes	No	SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	ProtMapper:24023801 SIGNOR:24023801
EPHB2	P29323	NRCAM	Q92823	Yes	Yes	No	SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	ProtMapper:24023801 SIGNOR:24023801
NRCAM	Q92823	ANK2	Q01484	Yes	Yes	No	HPRDSIGNOR	SIGNOR:7961622 HPRD:11449000

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	NRCAM WARS1	P23381 Q92823	0:0	hu.MAP
	CIAPIN1 NDOR1 NRCAM	Q6FI81 Q92823 Q9UHB4	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Polymer Precipitation	Western blotting	1	38731868

Sequence, Structure & Domains

Sequences

Length

1,304

Mass

143,890

Sequence

MQLKIMPKKKRLSAGRVPLILFLCQMISALEVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAETYANISWEYEGPEHVNFYVEYGVAGSKEEWRKEIVNGSRSFFGLKGLMPGTAYKVRVGAVGDSGFVSSEDVFETGPAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q92823-1; Sequence=Displayed; Name=2; IsoId=Q92823-2; Sequence=VSP_007841, VSP_007842; Name=3; IsoId=Q92823-3; Sequence=VSP_007838, VSP_007840; Name=4; IsoId=Q92823-4; Sequence=VSP_007837, VSP_007839, VSP_007840; Name=5; IsoId=Q92823-5; Sequence=VSP_007843; Name=6; IsoId=Q92823-6; Sequence=VSP_007838, VSP_045040

Alternative Sequence

35..40; Missing (in isoform 4); 241..259; Missing (in isoform 3 and isoform 6); 635..644; Missing (in isoform 4); 1051..1155; Missing (in isoform 3 and isoform 4); 1063..1155; Missing (in isoform 6); 1225; Y -> YRSLE (in isoform 5); 1226..1236; SDAEDHKPLKK -> RLFSFVSSASF (in isoform 2); 1237..1304; Missing (in isoform 2)

3D Structural Models

Turn

687..689

Helix

871..874

Beta Strand

651..656; 659..661; 663..668; 677..686; 694..703; 706..709; 720..727; 853..858; 861..865; 878..889; 901..909; 911..917; 923..934; 936..939; 943..946

3D Structure

NMR spectroscopy (2)

Domain & Motif Annotations

Compositional Bias

1199..1219; Basic and acidic residues; 1241..1250; Basic and acidic residues; 1288..1304; Polar residues

Domain (FT)

46..134; Ig-like 1; 141..235; Ig-like 2; 267..356; Ig-like 3; 361..448; Ig-like 4; 454..541; Ig-like 5; 545..632; Ig-like 6; 649..744; Fibronectin type-III 1; 746..843; Fibronectin type-III 2; 848..950; Fibronectin type-III 3; 954..1051; Fibronectin type-III 4; 1064..1156; Fibronectin type-III 5

Region

1199..1304; Disordered

Protein Families

Immunoglobulin superfamily
L1/neurofascin/NgCAM family

Sequence Similarities

Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

Clinical Relevance

Disease Involvement

Disease variantIntellectual disability

Antibody

HPA012606 CAB080588