Protein detail

NRCAM

Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)

Protein symbol NRCAM	UniProt ID Q92823	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification Disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)

Protein Class

Disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteins

Protein Function

Disease related genes
Predicted secreted proteins

Transmembrane

1168..1190; Helical

Transmembrane Count

Ensembl

ENSG00000091129

Entrez Gene Symbol

NRCAM

Gene Synonym

BravoKIAA0343

Gene Description

Neuronal cell adhesion molecule

Chromosome

Position

108147623-108456717

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificadipose tissueCell SpecificBrain inhibitory neuronsSingle-Nuclei Brain Specificeccentric medium spiny neuronBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Disease related genes
Predicted secreted proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
NRCAM	EPHB2	P29323	Y	1,276	phosphorylation	SIGNOR	SIGNOR:24023801
NRCAM	EPHB1	P54762	Y	1,276	phosphorylation	SIGNOR	SIGNOR:24023801

Ligand-Receptor Signaling

53 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No

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Regulatory Interaction Network

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NRCAM	Q92823	ANK1	P16157	Yes	Yes	No	WangCui2007SIGNORCA1	SIGNOR:7961622 CA1:7961622
NRCAM	Q92823	ANK3	Q12955	Yes	Yes	No	SIGNOR	SIGNOR:7961622
EPHB1	P54762	NRCAM	Q92823	Yes	Yes	No	SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	ProtMapper:24023801 SIGNOR:24023801
EPHB2	P29323	NRCAM	Q92823	Yes	Yes	No	SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	ProtMapper:24023801 SIGNOR:24023801
NRCAM	Q92823	ANK2	Q01484	Yes	Yes	No	HPRDSIGNOR	SIGNOR:7961622 HPRD:11449000

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	NRCAM WARS1	P23381 Q92823	0:0	hu.MAP
	CIAPIN1 NDOR1 NRCAM	Q6FI81 Q92823 Q9UHB4	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Polymer Precipitation	Western blotting	1	38731868

Sequence, Structure & Domains

Sequences

Length

1,304

Mass

143,890

Sequence

MQLKIMPKKKRLSAGRVPLILFLCQMISALEVPLDPKLLEDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAETYANISWEYEGPEHVNFYVEYGVAGSKEEWRKEIVNGSRSFFGLKGLMPGTAYKVRVGAVGDSGFVSSEDVFETGPAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDSDDSLVDYGEGVNGQFNEDGSFIGQYSGKKEKEPAEGNESSEAPSPVNAMNSFV

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q92823-1; Sequence=Displayed; Name=2; IsoId=Q92823-2; Sequence=VSP_007841, VSP_007842; Name=3; IsoId=Q92823-3; Sequence=VSP_007838, VSP_007840; Name=4; IsoId=Q92823-4; Sequence=VSP_007837, VSP_007839, VSP_007840; Name=5; IsoId=Q92823-5; Sequence=VSP_007843; Name=6; IsoId=Q92823-6; Sequence=VSP_007838, VSP_045040

Alternative Sequence

35..40; Missing (in isoform 4); 241..259; Missing (in isoform 3 and isoform 6); 635..644; Missing (in isoform 4); 1051..1155; Missing (in isoform 3 and isoform 4); 1063..1155; Missing (in isoform 6); 1225; Y -> YRSLE (in isoform 5); 1226..1236; SDAEDHKPLKK -> RLFSFVSSASF (in isoform 2); 1237..1304; Missing (in isoform 2)

3D Structural Models

Turn

687..689

Helix

871..874

Beta Strand

651..656; 659..661; 663..668; 677..686; 694..703; 706..709; 720..727; 853..858; 861..865; 878..889; 901..909; 911..917; 923..934; 936..939; 943..946

3D Structure

NMR spectroscopy (2)

Domain & Motif Annotations

Compositional Bias

1199..1219; Basic and acidic residues; 1241..1250; Basic and acidic residues; 1288..1304; Polar residues

Domain (FT)

46..134; Ig-like 1; 141..235; Ig-like 2; 267..356; Ig-like 3; 361..448; Ig-like 4; 454..541; Ig-like 5; 545..632; Ig-like 6; 649..744; Fibronectin type-III 1; 746..843; Fibronectin type-III 2; 848..950; Fibronectin type-III 3; 954..1051; Fibronectin type-III 4; 1064..1156; Fibronectin type-III 5

Region

1199..1304; Disordered

Protein Families

Immunoglobulin superfamily
L1/neurofascin/NgCAM family

Sequence Similarities

Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

Clinical Relevance

Disease Involvement

Disease variantIntellectual disability

Antibody

HPA012606 CAB080588