Protein detail

COR2A

Coronin-2A (IR10) (WD repeat-containing protein 2)

Entry name COR2A	UniProt ID Q92828	EVMP score 0.38
Frequency 4	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Coronin-2A (IR10) (WD repeat-containing protein 2)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000106789

Entrez Gene Symbol

CORO2A

Gene Synonym

IR10WDR2

Gene Description

Coronin 2A

Chromosome

Position

98120975-98192637

Frequency

EVMP Score

0.38

Fluorescence & Localization

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0017053 transcription repressor complex

Molecular Function

Biological Process

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
actin_regulation_adhesome	intracellular_intercellular_related	Adhesome	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
NCOR complex	CORO2A GPS2 HDAC3 NCOR1 TBL1X TBL1XR1	O15379 O60907 O75376 Q13227 Q92828 Q9BZK7	1:1:1:1:1:1	CompleatCORUM	CORUM:15Compleat:HC2029	12628926

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingFlow cytometry	9	38225453 38731868 24505114 36635400 40098346 37922300 36982312 40091455 31588238

Sequence, Structure & Domains

Sequences

Length

525

Mass

59,763

Sequence

MSWHPQYRSSKFRHVFGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGKLDPHYPKVCGHRGNVLDVKWNPFDDFEIASCSEDATIKIWSIPKQLLTRNLTAYRKELVGHARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKESVITSPMSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEASYKGHRASKVLFLGNLKKLMSTGTSRWNNRQVALWDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEVSADKPHLSYLTEYRSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPISMIVPRRSESYQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVSLRPGSELLRPHPLPAERPIFNSMAPASPRLLNQTEKLAAEDGWRSSSLLEEKMPRWAAEHRLEEKKTWLTNGFDVFECPPPKTENELLQMFYRQQEEIRRLRELLTQREVQAKQLELEIKNLRMGSEQL

3D Structural Models

Domain & Motif Annotations

Repeat

24..71; WD 1; 72..122; WD 2; 123..170; WD 3; 171..214; WD 4; 215..259; WD 5; 260..305; WD 6; 306..342; WD 7

Coiled Coil

485..524

Protein Families

WD repeat coronin family

Sequence Similarities

Belongs to the WD repeat coronin family.

Clinical Relevance

Antibody

HPA041161 HPA041302