Protein detail

HYAS1

Hyaluronan synthase 1 (EC 2.4.1.212) (Hyaluronate synthase 1) (Hyaluronic acid synthase 1) (HA synthase 1) (HuHAS1)

Entry name HYAS1	UniProt ID Q92839	EVMP confidence score 0.88
Supporting publications (n) 22	Transmembrane count 7	Protein classification EnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Hyaluronan synthase 1 (EC 2.4.1.212) (Hyaluronate synthase 1) (Hyaluronic acid synthase 1) (HA synthase 1) (HuHAS1)

Protein Class (5)

EnzymesMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Transporters
Predicted intracellular proteins

Transmembrane

25..45; Helical; Name=1; 52..72; Helical; Name=2; 399..419; Helical; Name=3; 430..450; Helical; Name=4; 457..477; Helical; Name=5; 497..517; Helical; Name=6; 540..560; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000105509

Entrez Gene Symbol

HAS1

Gene Synonym

HAS

Gene Description

Hyaluronan synthase 1

Chromosome

Position

51713112-51723991

Supporting publications (n)

EVMP confidence score

0.88

Fluorescence & Localization3

Tissue Specificskin 1Cell SpecificMelanocytesSingle-Nuclei Brain Specificcommitted oligodendrocyte precursor

Function & Pathway6

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Transporters
Predicted intracellular proteins

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

Reactome (3)

Mediation Categories

Metabolism mediation

Relations & Evidence18

Ligand-Receptor Signaling (12)

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	Cellinker	Yes	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Protein Complex Composition (5)

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HAS1 hyaluronan biosynthesis complex	HAS1	Q92839	2	ComplexPortal	intact:EBI-48419357	14755292 26474840 25795779
HAS1-HAS3 hyaluronan biosynthesis complex	HAS1 HAS3	O00219 Q92839	1:1	ComplexPortal	intact:EBI-48415617	14760721 14755292 26474840 25795779
	EWSR1 GEMIN5 HAS1 HAX1	O00165 Q01844 Q8TEQ6 Q92839	0:0:0:0	Havugimana2012	Havugimana2012:C_351
	EIF1B EIF3A EIF3B EIF3C EIF3G EIF3H EIF3I EIF3J EIF4G1 EIF5 EIF6 HAS1 HSPA4L UBC USP3	O15372 O60739 O75821 O75822 O95757 P0CG48 P55010 P55884 P56537 Q04637 Q13347 Q14152 Q92839 Q99613 Q9Y6I4	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8236
	C2orf49 DDX1 FAM98B GEMIN5 HAS1 HMCN1 RTCB RTRAF	Q52LJ0 Q8TEQ6 Q92499 Q92839 Q96RW7 Q9BVC5 Q9Y224 Q9Y3I0	0:0:0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_561

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	27863537 32944193

Sequence, Structure & Domains5

Sequences

Length

577

Mass

64,704

Sequence

MRQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGAFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARALLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGAGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLALVTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYHLAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV

Domain & Motif Annotations

Protein Families

NodC/HAS family

Sequence Similarities

Belongs to the NodC/HAS family.

Clinical Relevance1

Antibody

HPA067602

Supporting Publications22

PMID	Title	Abstract
26378940	Redefining the Breast Cancer Exosome Proteome by Tandem Mass Tag Quantitative Proteomics and Multivariate Cluster Analysis.	No abstract available
27863537	High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.	No abstract available
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
28590090	Motile hepatocellular carcinoma cells preferentially secret sugar metabolism regulatory proteins via exosomes.	No abstract available
28986585	Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.	No abstract available
29148239	Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.	No abstract available
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.
30950185	Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer.	No abstract available
31196968	Cancer Cell Derived Small Extracellular Vesicles Contribute to Recipient Cell Metastasis Through Promoting HGF/c-Met Pathway.	No abstract available
32089743	Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.	No abstract available

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