Protein detail
MRP2
ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2)
Entry name MRP2 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 4 | Transmembrane count 17 | Protein classification Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2)
Protein Class (9)
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function (7)
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of cofactor/vitamin metabolism
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
28..48; Helical; Name=1; 69..89; Helical; Name=2; 94..114; Helical; Name=3; 127..147; Helical; Name=4; 166..186; Helical; Name=5; 314..334; Helical; Name=6; 361..381; Helical; Name=7; 438..458; Helical; Name=8; 462..482; Helical; Name=9; 545..565; Helical; Name=10; 588..608; Helical; Name=11; 972..992; Helical; Name=12; 1034..1054; Helical; Name=13; 1098..1118; Helical; Name=14; 1120..1140; Helical; Name=15; 1212..1232; Helical; Name=16; 1235..1255; Helical; Name=17
Transmembrane Count
17
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
CMOATcMRPDJSMRP2
Gene Description
ATP binding cassette subfamily C member 2
Chromosome
10
Position
99782640-99852594
Supporting publications (n)
4
EVMP confidence score
0.25
Fluorescence & Localization5
Tissue SpecificplacentaCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway7
Protein Function (7)
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of cofactor/vitamin metabolism
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- ENZYME proteins
- Transporters:Primary Active Transporters
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component (4)
Molecular Function (11)
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0008514 organic anion transmembrane transporter activity
- GO:0008559 ABC-type xenobiotic transporter activity
- GO:0015127 bilirubin transmembrane transporter activity
- GO:0015431 ABC-type glutathione S-conjugate transporter activity
- GO:0016887 ATP hydrolysis activity
- GO:0042626 ATPase-coupled transmembrane transporter activity
- GO:0042910 xenobiotic transmembrane transporter activity
- GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity
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Biological Process (3)
KEGG (5)
Reactome (10)
- R-hsa-382556 abc family proteins mediated transport
- R-hsa-5619084 abc transporter disorders
- R-hsa-9749641 aspirin adme
- R-hsa-9754706 atorvastatin adme
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-9748784 drug adme
- R-hsa-189483 heme degradation
- R-hsa-189445 metabolism of porphyrins
- R-hsa-9753281 paracetamol adme
- R-hsa-382551 transport of small molecules
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence29
Ligand-Receptor Signaling (27)
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | HGNC | No | Yes | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| abcc | transporter | HGNC | No | Yes | No | No | No |
| abc | transporter | DGIdb | No | Yes | No | No | No |
| transporter | transporter | DGIdb | No | Yes | No | No | No |
| abcc | transporter | Almen2009 | No | Yes | No | No | No |
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Protein Complex Composition (1)
Sequence, Structure & Domains11
Sequences
Length
1,545
Mass
174,207
Sequence
MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGYLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLVLLIQYSRQWCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILIFSAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTKF
3D Structural Models
Turn
90..93; 205..208; 223..225; 336..338; 436..439; 809..812; 1012..1014; 1365..1367; 1463..1466; 1483..1485; 1498..1500
Helix
2..5; 13..15; 25..52; 63..89; 99..120; 121..123; 130..155; 162..181; 194..196; 200..204; 210..218; 231..233; 235..259; 310..335; 339..351; 357..404; 409..412; 417..425; 427..435; 440..459; 460..463; 464..507; 509..514; 518..568; 576..617; 677..684; 715..720; 727..736; 740..743; 749..751; 756..758; 763..776; 787..790; 793..802; 825..827; 845..851; 854..858; 859..862; 895..897; 898..916; 927..934; 964..974; 976..1005; 1006..1008; 1017..1064; 1069..1074; 1077..1092; 1094..1119; 1121..1123; 1124..1168; 1170..1175; 1179..1228; 1230..1232; 1235..1245; 1248..1265; 1267..1276; 1342..1347; 1370..1374; 1391..1395; 1403..1412; 1416..1419; 1432..1434; 1439..1453; 1469..1482; 1495..1497; 1520..1523; 1527..1534
Beta Strand
6..8; 17..20; 124..128; 191..193; 353..355; 625..631; 634..647; 653..657; 666..670; 688..697; 701..704; 712..714; 746..748; 753..755; 780..785; 805..808; 813..818; 822..824; 829..835; 838..843; 891..894; 1300..1307; 1316..1323; 1329..1333; 1354..1360; 1377..1380; 1388..1390; 1422..1427; 1435..1437; 1456..1461; 1486..1491; 1501..1516
3D Structure
Electron microscopy (11)
Domain & Motif Annotations
Domain (FT)
322..605; ABC transmembrane type-1 1; 637..861; ABC transporter 1; 979..1264; ABC transmembrane type-1 2; 1300..1534; ABC transporter 2
Region
253..284; Disordered
Protein Families (3)
- ABC transporter superfamily
- ABCC family
- Conjugate transporter (TC 3.A.1.208) subfamily
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Clinical Relevance7
Disease Involvement (3)
Cancer-related genesDisease variantFDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs (49)
CEFUROXIME AXETILMK-571CEFMETAZOLECEPHALEXIN ANHYDROUSNULL2(S)-AMINO-6-BORONOHEXANOIC ACIDTENOFOVIRCEFTRIAXONEEMTRICITABINEFLUOROURACILLAMIVUDINENEVIRAPINERIMONABANTBENZBROMARONEDICLOFENAC SODIUMATAZANAVIRSIMVASTATINABACAVIRDEFERASIROXLEUCOVORIN CALCIUMALKYLSULFONATE COMPOUNDPACLITAXELRITONAVIREPIRUBICINCYCLOSPORINEROSUVASTATINEFAVIRENZPEMETREXED DISODIUMOXALIPLATINSULFINPYRAZONEDELAVIRDINECEFACLOR ANHYDROUSRASAGILINELUMEFANTRINEERYTHROMYCINA1PCEFADROXIL ANHYDROUSCOMPOUND 9 [PMID: 23472952]VORICONAZOLETRABECTEDINSORAFENIBCEPHRADINECEFOPERAZONEOFTASCEINECYCLOPHOSPHAMIDE ANHYDROUSCEFAMANDOLECEFOXITIN SODIUMLACOSAMIDESN-38
Antibody
Interaction Protein
ENSG00000109320
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 32560723 | T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles. | No abstract available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No abstract available |