Protein detail
ARHG1
Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5)
Entry name ARHG1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5)
Protein Class (4)
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function (3)
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
LBCL2P115-RHOGEFSUB1.5
Gene Description
Rho guanine nucleotide exchange factor 1
Chromosome
19
Position
41883173-41930150
Supporting publications (n)
3
EVMP confidence score
0.53
Function & Pathway
Protein Function (3)
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Disease related genes
- Predicted intracellular proteins
Cellular Component (3)
Molecular Function (5)
Biological Process (3)
KEGG (10)
- hsa04270 Vascular smooth muscle contraction
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04928 Parathyroid hormone synthesis, secretion and action
- KEGG:hsa05130 Pathogenic Escherichia coli infection
- KEGG:hsa05135 Yersinia infection
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05417 Lipid and atherosclerosis
Reactome (11)
- R-hsa-204998 cell death signalling via nrage nrif and nade
- R-hsa-73887 death receptor signaling
- R-hsa-416482 g alpha 12 13 signalling events
- R-hsa-193648 nrage signals death through jnk
- R-hsa-193704 p75 ntr receptor mediated signalling
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013026 rhob gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-372790 signaling by gpcr
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Mediation Categories
Receptor-signaling mediation
Relations & Evidence18
Enzyme-Mediated Modification (3)
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ARHGEF1 | JAK2 | O60674 | Y | 738 | phosphorylation | Sparser_ProtMapperSIGNORProtMapperdbPTMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:20098430dbPTM:20098430ProtMapper:20098430ProtMapper:25981295 |
| ARHGEF1 | JAK2 | O60674 | Y | 753 | phosphorylation | MIMPPhosphoSite_MIMP | |
| ARHGEF1 | PRKCA | P17252 | S | 240 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Regulatory Interaction Network (4)
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GNA13 | Q14344 | ARHG1 | Q92888 | Yes | Yes | WangKEGG-MEDICUSSIGNORHPRDCui2007HINTCA1SPIKE_LC | HINT:20300064CA1:9641916SIGNOR:9641915HPRD:12681510SIGNOR:9641916SIGNOR:14607242HINT:15735747HPRD:9641916HINT:14634662HINT:12681510SPIKE_LC:16189514 | |
| KPCA | P17252 | ARHG1 | Q92888 | Yes | Yes | PhosphoPointSIGNORProtMapperHPRDPhosphoSitePhosphoSite_ProtMapper | HPRD:12754211PhosphoSite:32881857SIGNOR:32881857 | |
| JAK2 | O60674 | ARHG1 | Q92888 | Yes | Yes | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperdbPTMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | dbPTM:20098430ProtMapper:20098430ProtMapper:25981295SIGNOR:20098430PhosphoSite:20098430 | |
| ARHG1 | Q92888 | RHOA | P61586 | Yes | Yes | KEGG-MEDICUSSIGNORCui2007HINTBioGRIDACSNWang | ACSN:9113980HINT:12748184ACSN:9789025HINT:34591642SIGNOR:32203420HINT:32203420SIGNOR:10836144BioGRID:12748184ACSN:11149925ACSN:9641915HINT:33961781 |
Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GNA14-p115RhoGEF complex | ARHGEF1GNA14 | O95837Q92888 | 1:1 | CompleatCORUM | CORUM:3177Compleat:HC2665 | 15735747 |
| ARCN1ARHGEF1BET1LCOPACOPB1COPB2COPECOPG1COPG2COPZ1GBF1GOSR2RHOBSEC22BUBC | O14579O14653O75396P0CG48P35606P48444P53618P53621P61923P62745Q92538Q92888Q9NYM9Q9UBF2Q9Y678 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9874 | ||
| ARHGEF1 | Q92888 | 2 | PDB | PDB:3odoPDB:3odwPDB:3p6aPDB:3odx | ||
| ARHGEF17RASL12RERG | Q96A58Q96PE2Q9NYN1 | 0:0:0 | hu.MAP2 | |||
| ARHGEF17RASL12 | Q96PE2Q9NYN1 | 0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37354366 |
Sequence, Structure & Domains
Sequences
Length
912
Mass
102,435
Sequence
MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLMALLQHVALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAARWNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q92888-1; Sequence=Displayed; Name=2; IsoId=Q92888-2; Sequence=VSP_008125; Name=3; IsoId=Q92888-3; Sequence=VSP_037766; Name=4; IsoId=Q92888-4; Sequence=VSP_037766, VSP_008125, VSP_057289
Alternative Sequence
1; M -> MASLSTWSSPAEPREM (in isoform 3 and isoform 4); 76..108; Missing (in isoform 2 and isoform 4); 831..912; VLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCT -> GVGGGILPPETPPVSAWGELCPPAWLHLRFPPRKAFCKKERNGGEDVRDHPHPHSCRSISHPEGLRRGSCGPRLGGAQLGLLAPHEPRPSLPPALCLGDSGLHSGGHHGDPGHLSIACGGHPSTPTPKCLRSVFIP (in isoform 4)
3D Structural Models
Turn
26..33; 127..129; 399..401
Helix
49..52; 56..69; 73..84; 89..103; 116..122; 132..144; 147..162; 169..176; 183..203; 205..207; 212..228; 404..407; 413..441; 443..449; 454..460; 464..484; 493..500; 502..517; 519..532; 534..544; 547..549; 554..557; 560..577; 582..621; 625..629; 633..635; 710..712; 745..760
Beta Strand
18..20; 636..638; 644..646; 648..661; 663..681; 684..686; 694..697; 706..709; 713..717; 719..721; 724..729; 737..741
3D Structure
X-ray crystallography (7)
Domain & Motif Annotations
Compositional Bias
283..313; Basic and acidic residues; 365..381; Acidic residues; 777..789; Low complexity
Coiled Coil
865..896
Domain (CC)
The RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity.; DOMAIN: The DH domain is involved in interaction with CCPG1..
Domain (FT)
41..232; RGSL; 416..605; DH; 647..760; PH
Region
248..413; Disordered; 763..802; Disordered; 841..865; Disordered
Clinical Relevance
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 37457308 | Platelet-derived extracellular vesicles formulated with hyaluronic acid gels for application at the bone-implant interface: An animal study. | No related sentences available |
| 37516879 | Exosomes promote hFOB1.19 proliferation and differentiation via LINC00520. | After human osteoblasts hFOB1.19 were exposed to the obtained exosomes, cell survival, cell cycle, apoptosis and calcium deposits of hFOB1.19 cell were detected by MTT, 7-aminoactinomycin D, Annexin V-FITC/propidium iodide and Alizarin red staining, respectively. |
| 39155501 | The efficacy of adipose stem cell-derived exosomes in hair regeneration based on a preclinical and clinical study. | ASC-Exosomes impact hDPCs, increasing proliferation and the upregulation of hair growth-related genes, including ALP, VCAN, β-catenin, and LEF-1. First, using human hair follicle (HF) dermal papilla cells (hDPCs) treated with ASC-Exosomes, ALP, VCAN, β-catenin, and LEF-1 levels with RT-PCR and p-GSK3β, GSK3β, β-catenin, ALP, and β-actin levels with western blot analysis were assessed. |