Protein detail
SO2A1
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) (OATP2A1) (PHOAR2) (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2) (SLC21A2)
Entry name SO2A1 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 12 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) (OATP2A1) (PHOAR2) (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2) (SLC21A2)
Protein Class (6)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (5)
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Digestive system diseases:Gastrointestinal diseases
Transmembrane
33..52; Helical; Name=1; 72..92; Helical; Name=2; 99..123; Helical; Name=3; 168..196; Helical; Name=4; 216..236; Helical; Name=5; 255..279; Helical; Name=6; 322..343; Helical; Name=7; 364..387; Helical; Name=8; 392..415; Helical; Name=9; 519..541; Helical; Name=10; 551..576; Helical; Name=11; 611..629; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
MATR1OATP2A1PGTSLC21A2
Gene Description
Solute carrier organic anion transporter family member 2A1
Chromosome
3
Position
133932701-134052184
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAdrenal medulla cells
Function & Pathway
Protein Function (5)
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Digestive system diseases:Gastrointestinal diseases
Cellular Component (5)
Molecular Function (3)
Biological Process (3)
Reactome (6)
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence28
Ligand-Receptor Signaling (26)
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | Yes | ||||
| cell_surface | cell_surface | Surfaceome | Yes | ||||
| cell_surface | cell_surface | OmniPath | Yes | ||||
| receptor | receptor | scConnect | Yes | Yes | |||
| transmembrane | transmembrane_predicted | Phobius | Yes |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30550287 |
Sequence, Structure & Domains
Sequences
Length
643
Mass
70,044
Sequence
MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI
3D Structural Models
Turn
91..94; 184..186; 201..203; 312..314; 333..338; 346..348; 394..396; 515..521; 530..533; 564..567
Helix
27..29; 31..63; 67..90; 97..116; 118..121; 187..197; 204..214; 215..217; 218..229; 243..246; 257..272; 273..277; 308..311; 315..323; 326..332; 339..345; 349..356; 361..389; 397..410; 411..414; 415..418; 443..446; 469..472; 512..514; 522..529; 534..543; 546..548; 549..563; 568..578; 599..628
Beta Strand
181..183; 231..234; 236..239; 250..252; 425..430; 458..463; 465..467; 474..477; 482..486; 488..492; 496..499; 502..505; 582..585; 591..596
3D Structure
Electron microscopy (6); X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
438..496; Kazal-like
Protein Families
Organo anion transporter (TC 2.A.60) family
Sequence Similarities
Belongs to the organo anion transporter (TC 2.A.60) family.
Clinical Relevance
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 38071653 | Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer's disease pathogenesis. | Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer's disease pathogenesis. |