Protein detail

SO2A1

Solute carrier organic anion transporter family member 2A1 (SLCO2A1) (OATP2A1) (PHOAR2) (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2) (SLC21A2)

Entry name SO2A1	UniProt ID Q92959	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 12	Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Solute carrier organic anion transporter family member 2A1 (SLCO2A1) (OATP2A1) (PHOAR2) (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2) (SLC21A2)

Protein Class (6)

Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (5)

Human disease related genes:Musculoskeletal diseases:Skeletal diseases
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Digestive system diseases:Gastrointestinal diseases

Transmembrane

33..52; Helical; Name=1; 72..92; Helical; Name=2; 99..123; Helical; Name=3; 168..196; Helical; Name=4; 216..236; Helical; Name=5; 255..279; Helical; Name=6; 322..343; Helical; Name=7; 364..387; Helical; Name=8; 392..415; Helical; Name=9; 519..541; Helical; Name=10; 551..576; Helical; Name=11; 611..629; Helical; Name=12

Transmembrane Count

Ensembl

ENSG00000174640

Entrez Gene Symbol

SLCO2A1

Gene Synonym (4)

MATR1OATP2A1PGTSLC21A2

Gene Description

Solute carrier organic anion transporter family member 2A1

Chromosome

Position

133932701-134052184

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Tissue SpecificbrainCell SpecificAdrenal medulla cells

Function & Pathway6

Protein Function (5)

Human disease related genes:Musculoskeletal diseases:Skeletal diseases
Potential drug targets
Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Digestive system diseases:Gastrointestinal diseases

Cellular Component (5)

Molecular Function (3)

Biological Process (3)

Reactome (6)

Mediation Categories (2)

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence28

Ligand-Receptor Signaling (26)

26 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

Page 3 of 3Previous

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	SLCO2A1	Q92959	2	PDB	PDB:8kgi

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	30550287

Sequence, Structure & Domains10

Sequences

Length

643

Mass

70,044

Sequence

MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI

3D Structural Models

Turn

91..94; 184..186; 201..203; 312..314; 333..338; 346..348; 394..396; 515..521; 530..533; 564..567

Helix

27..29; 31..63; 67..90; 97..116; 118..121; 187..197; 204..214; 215..217; 218..229; 243..246; 257..272; 273..277; 308..311; 315..323; 326..332; 339..345; 349..356; 361..389; 397..410; 411..414; 415..418; 443..446; 469..472; 512..514; 522..529; 534..543; 546..548; 549..563; 568..578; 599..628

Beta Strand

181..183; 231..234; 236..239; 250..252; 425..430; 458..463; 465..467; 474..477; 482..486; 488..492; 496..499; 502..505; 582..585; 591..596

3D Structure

Electron microscopy (6); X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

438..496; Kazal-like

Protein Families

Organo anion transporter (TC 2.A.60) family

Sequence Similarities

Belongs to the organo anion transporter (TC 2.A.60) family.

Clinical Relevance3

Disease Involvement

Disease variant

Drugs

DINOPROSTONE

Antibody

HPA013742

Supporting Publications1

PMID	Title	Abstract
38071653	Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer's disease pathogenesis.	No abstract available