Protein detail

TNR25

Tumor necrosis factor receptor superfamily member 25 (Apo-3) (Apoptosis-inducing receptor AIR) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death receptor 3) (Lymphocyte-associated receptor of death) (LARD) (Protein WSL) (Protein WSL-1)

Entry name TNR25	UniProt ID Q93038	EVMP score 0.38
Frequency 2	Transmembrane count 1	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Function

Predicted secreted proteins

Transmembrane

200..220; Helical

Transmembrane Count

Ensembl

ENSG00000215788

Entrez Gene Symbol

TNFRSF25

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificSertoli cells

Function & Pathway

Protein Function

Predicted secreted proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04060 Cytokine-cytokine receptor interaction

Reactome

Mediation Categories

Clinical-translation mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

63 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	Yes	Yes	No
receptor	receptor	HPMR	No	Yes	Yes	Yes	No
receptor	receptor	ICELLNET	No	Yes	Yes	Yes	No
receptor	receptor	CellChatDB	No	Yes	Yes	Yes	No
receptor	receptor	CellTalkDB	No	Yes	Yes	Yes	No
receptor	receptor	Surfaceome	No	Yes	Yes	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	Yes	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	Yes	Yes	No
receptor	receptor	LRdb	No	Yes	Yes	Yes	No
tumor_necrosis_factor	receptor	Almen2009	No	Yes	Yes	Yes	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TNR25	Q93038	TRADD	Q15628	Yes	Yes	No	SIGNORHPRDCui2007BioGRIDWang	SIGNOR:14585074 BioGRID:21421854 HPRD:8934525
TNF15	O95150	TNR25	Q93038	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORInnateDBDIPUniProt_LRdbHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:11911831 ICELLNET:11239407 connectomeDB2020:11911831 CellTalkDB:11911831 HPRD:11911831 SIGNOR:14585074 HPMR:11911831 LRdb:11911831 InnateDB:20403353 DIP:21300286

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	TNFRSF25	Q93038	4	PDB	PDB:5ygsPDB:5yevPDB:5ygp

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	27	40985879 40189497 38207106 38207106 36064647 38113368 37322475 31382537 41068253 32357574 33592500 32854315 40940449 34473505 37563857 41307968 36146834 27821849 31805958 38607062 38207106 38716512 39001700 39207047 32854315 37926756 40831280

Sequence, Structure & Domains

Sequences

Length

417

Mass

45,385

Sequence

MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQVALENCSAVADTRCGCKPGWFVECQVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCLPGFYEHGDGCVSCPTSTLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLSPLDSAHTLLAPPDSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRALGPAAAPTLSPESPAGSPAMMLQPGPQLYDVMDAVPARRWKEFVRTLGLREAEIEAVEVEIGRFRDQQYEMLKRWRQQQPAGLGAVYAALERMGLDGCVEDLRSRLQRGP

Alternative Products

Event=Alternative splicing; Named isoforms=12; Name=1; Synonyms=WSL-1, LARD-1A; IsoId=Q93038-1; Sequence=Displayed; Name=2; Synonyms=LARD-1B; IsoId=Q93038-2; Sequence=VSP_006504; Name=3; Synonyms=WSL-S1, LARD-3; IsoId=Q93038-3; Sequence=VSP_006497, VSP_006498; Name=4; Synonyms=WSL-S2, LARD-2; IsoId=Q93038-4; Sequence=VSP_006501, VSP_006502; Name=5; Synonyms=LARD-4, LARD-11; IsoId=Q93038-5; Sequence=VSP_006495; Name=6; Synonyms=LARD-5; IsoId=Q93038-6; Sequence=VSP_006491, VSP_006495; Name=7; Synonyms=LARD-6; IsoId=Q93038-7; Sequence=VSP_006491, VSP_006493, VSP_006494; Name=8; Synonyms=LARD-7; IsoId=Q93038-8; Sequence=VSP_006492; Name=9; Synonyms=LARD-8; IsoId=Q93038-9; Sequence=VSP_006491; Name=10; Synonyms=LARD-9; IsoId=Q93038-10; Sequence=VSP_006503; Name=11; Synonyms=Beta; IsoId=Q93038-11; Sequence=VSP_006496; Name=12; Synonyms=Beta soluble; IsoId=Q93038-12; Sequence=VSP_006499, VSP_006500

Alternative Sequence

54..236; Missing (in isoform 8); 54..98; Missing (in isoform 6, isoform 7 and isoform 9); 156..171; SRRDTDCGTCLPGFYE -> HPSVTLGQRPHPSSTS (in isoform 7); 172..417; Missing (in isoform 7); 182..417; Missing (in isoform 5 and isoform 6); 182..277; STLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLSPLDSAHTLLAPPDSSEKICTVQLV -> PPPSLAGAPWGAVQSAVPLSVAGGRVGGVLGMRVGELGWTEGRRVRRGATTQHPPAAFSVLGPGAPGWPCGPPPAWGHPDLHIPPLLASQAPGYCR (in isoform 12); 182..218; STLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGA -> VLGPGAPGWPCGPPPAWGHPDLHIPPLLASQAPGYCR (in isoform 3); 182..200; STLGSCPERCAAVCGWRQM -> PPPSLAGAPWGAVQSAVPLSVAGGRVGV (in isoform 11); 200..253; MFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLS -> SRWCAGNARGRTGMDRGEAGEEGGNHPTPTSCFQCSGSRCSWLALWSPSCLGPP (in isoform 4); 200..237; MFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTAD -> N (in isoform 10); 219..417; Missing (in isoform 3); 236; A -> AA (in isoform 2); 254..417; Missing (in isoform 4); 278..417; Missing (in isoform 12)

3D Structural Models

Turn

339..341; 383..385

Helix

328..333; 334..338; 347..354; 359..382; 390..397; 401..414

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Repeat

34..71; TNFR-Cys 1; 72..115; TNFR-Cys 2; 116..163; TNFR-Cys 3; 164..192; TNFR-Cys 4

Domain (FT)

332..413; Death

Clinical Relevance

Related Diseases

Solid tumour/cancer

Biomarker

Phase 1

Drugs

TL1A