Protein detail
TNR25
Tumor necrosis factor receptor superfamily member 25 (Apo-3) (Apoptosis-inducing receptor AIR) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death receptor 3) (Lymphocyte-associated receptor of death) (LARD) (Protein WSL) (Protein WSL-1)
Entry name TNR25 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Tumor necrosis factor receptor superfamily member 25 (Apo-3) (Apoptosis-inducing receptor AIR) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death receptor 3) (Lymphocyte-associated receptor of death) (LARD) (Protein WSL) (Protein WSL-1)
Protein Function
Predicted secreted proteins
Transmembrane
200..220; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization1
Cell SpecificSertoli cells
Function & Pathway7
Protein Function
Predicted secreted proteins
Cellular Component (3)
Molecular Function (2)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Clinical-translation mediationImmune mediation
Relations & Evidence67
Ligand-Receptor Signaling (63)
63 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | Yes | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_location | No | No | Yes | Yes | No |
| secreted | secreted | HPA_secretome | No | No | Yes | Yes | No |
| secreted | secreted | OmniPath | No | No | Yes | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
| ligand | ligand | CellPhoneDB | Yes | No | Yes | Yes | No |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TNR25 | Q93038 | TRADD | Q15628 | Yes | Yes | No | SIGNORHPRDCui2007BioGRIDWang | SIGNOR:14585074BioGRID:21421854HPRD:8934525 |
| TNF15 | O95150 | TNR25 | Q93038 | Yes | Yes | No | iTALKGuide2Pharma_LRdbICELLNETSIGNORInnateDBDIPUniProt_LRdbHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:11911831ICELLNET:11239407connectomeDB2020:11911831CellTalkDB:11911831HPRD:11911831SIGNOR:14585074HPMR:11911831LRdb:11911831InnateDB:20403353DIP:21300286 |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry | 27 | 409858794018949738207106382071063606464738113368373224753138253741068253323575743359250032854315409404493447350537563857413079683614683427821849318059583860706238207106387165123900170039207047328543153792675640831280 |
Sequence, Structure & Domains10
Sequences
Length
417
Mass
45,385
Sequence
MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQVALENCSAVADTRCGCKPGWFVECQVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCLPGFYEHGDGCVSCPTSTLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLSPLDSAHTLLAPPDSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRALGPAAAPTLSPESPAGSPAMMLQPGPQLYDVMDAVPARRWKEFVRTLGLREAEIEAVEVEIGRFRDQQYEMLKRWRQQQPAGLGAVYAALERMGLDGCVEDLRSRLQRGP
Alternative Products
Event=Alternative splicing; Named isoforms=12; Name=1; Synonyms=WSL-1, LARD-1A; IsoId=Q93038-1; Sequence=Displayed; Name=2; Synonyms=LARD-1B; IsoId=Q93038-2; Sequence=VSP_006504; Name=3; Synonyms=WSL-S1, LARD-3; IsoId=Q93038-3; Sequence=VSP_006497, VSP_006498; Name=4; Synonyms=WSL-S2, LARD-2; IsoId=Q93038-4; Sequence=VSP_006501, VSP_006502; Name=5; Synonyms=LARD-4, LARD-11; IsoId=Q93038-5; Sequence=VSP_006495; Name=6; Synonyms=LARD-5; IsoId=Q93038-6; Sequence=VSP_006491, VSP_006495; Name=7; Synonyms=LARD-6; IsoId=Q93038-7; Sequence=VSP_006491, VSP_006493, VSP_006494; Name=8; Synonyms=LARD-7; IsoId=Q93038-8; Sequence=VSP_006492; Name=9; Synonyms=LARD-8; IsoId=Q93038-9; Sequence=VSP_006491; Name=10; Synonyms=LARD-9; IsoId=Q93038-10; Sequence=VSP_006503; Name=11; Synonyms=Beta; IsoId=Q93038-11; Sequence=VSP_006496; Name=12; Synonyms=Beta soluble; IsoId=Q93038-12; Sequence=VSP_006499, VSP_006500
Alternative Sequence
54..236; Missing (in isoform 8); 54..98; Missing (in isoform 6, isoform 7 and isoform 9); 156..171; SRRDTDCGTCLPGFYE -> HPSVTLGQRPHPSSTS (in isoform 7); 172..417; Missing (in isoform 7); 182..417; Missing (in isoform 5 and isoform 6); 182..277; STLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLSPLDSAHTLLAPPDSSEKICTVQLV -> PPPSLAGAPWGAVQSAVPLSVAGGRVGGVLGMRVGELGWTEGRRVRRGATTQHPPAAFSVLGPGAPGWPCGPPPAWGHPDLHIPPLLASQAPGYCR (in isoform 12); 182..218; STLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGA -> VLGPGAPGWPCGPPPAWGHPDLHIPPLLASQAPGYCR (in isoform 3); 182..200; STLGSCPERCAAVCGWRQM -> PPPSLAGAPWGAVQSAVPLSVAGGRVGV (in isoform 11); 200..253; MFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLS -> SRWCAGNARGRTGMDRGEAGEEGGNHPTPTSCFQCSGSRCSWLALWSPSCLGPP (in isoform 4); 200..237; MFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTAD -> N (in isoform 10); 219..417; Missing (in isoform 3); 236; A -> AA (in isoform 2); 254..417; Missing (in isoform 4); 278..417; Missing (in isoform 12)
3D Structural Models
Turn
339..341; 383..385
Helix
328..333; 334..338; 347..354; 359..382; 390..397; 401..414
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Repeat
34..71; TNFR-Cys 1; 72..115; TNFR-Cys 2; 116..163; TNFR-Cys 3; 164..192; TNFR-Cys 4
Domain (FT)
332..413; Death