Protein detail

LPP

Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma)

Entry name LPP	UniProt ID Q93052	EVMP confidence score 0.72
Supporting publications (n) 18	Transmembrane count	Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma)

Protein Class (5)

Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (4)

Cancer-related genes:Mutational cancer driver genes
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000145012

Entrez Gene Symbol

LPP

Gene Description

LIM domain containing preferred translocation partner in lipoma

Chromosome

Position

188153284-188890671

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization

Cell SpecificAdipocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function (4)

Cancer-related genes:Mutational cancer driver genes
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Disease related genes
Predicted intracellular proteins

Cellular Component (5)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence54

Enzyme-Mediated Modification (8)

8 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
LPP	SRC	P12931	Y	301	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
LPP	SRC	P12931	Y	244	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
LPP	SRC	P12931	Y	300	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
LPP	EGFR	P00533	Y	301	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:15951569
LPP	EGF	P01133	S	116	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:17081983
LPP	IGF1R	P08069	Y	300	phosphorylation	KEA	KEA:17570479
LPP	INSR	P06213	Y	301	phosphorylation	KEA	KEA:17570479
LPP	LCK	P06239	Y	301	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (16)

16 records.

Category	Parent	Database	Transmitter	Receiver
adhesion_cytoskeleton_adaptor	intracellular_intercellular_related	Adhesome	Yes
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes
plasma_membrane	plasma_membrane	UniProt_location
plasma_membrane	plasma_membrane	Cellinker
plasma_membrane	plasma_membrane	OmniPath
receptor	receptor	Cellinker		Yes

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SRC	P12931	LPP	Q93052	Yes			PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:28436416

Protein Complex Composition (28)

28 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
BRSK1 EIF2AK4 HSPA1B PHLPP1 PHLPP2 UBC USP1 USP12 USP46 WDR48	O60346 O75317 O94782 P0CG48 P0DMV9 P62068 Q6ZVD8 Q8TAF3 Q8TDC3 Q9P2K8	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5421
PHLPP1 PHLPP2 RPS12 UBC USP1 USP12 USP38 USP46 WDR48	O60346 O75317 O94782 P0CG48 P25398 P62068 Q6ZVD8 Q8NB14 Q8TAF3	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9557
HSPA13 PHLPP1 PHLPP2 UBC USP1 USP12 USP46 VAT1 WDR48	O60346 O75317 O94782 P0CG48 P48723 P62068 Q6ZVD8 Q8TAF3 Q99536	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6628
H2BC21 PHLPP1 PHLPP2 UBC USP1 USP12 USP46 WDR48	O60346 O75317 O94782 P0CG48 P62068 Q16778 Q6ZVD8 Q8TAF3	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3725
ALDH9A1 HSPA4 PHLPP1 PHLPP2 USP1 USP12 USP46 WDR48	O60346 O75317 O94782 P34932 P49189 P62068 Q6ZVD8 Q8TAF3	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6877
EIF2AK4 PHLPP1 PHLPP2 TSSK4 UBC USP1 USP46 WDR48	O60346 O94782 P0CG48 P62068 Q6SA08 Q6ZVD8 Q8TAF3 Q9P2K8	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9258
ATG5 CLPP ECHS1 PRKAB1 RBM18 RGN	P30084 Q15493 Q16740 Q96H35 Q9H1Y0 Q9Y478	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7808
PHLPP2 USP46	P62068 Q6ZVD8	0:0	hu.MAP
PHLPP2 USP46 WDR20	P62068 Q6ZVD8 Q8TBZ3	1:1:1	CompleatCFinder	Compleat:HC7053
LIMD1 LPP PPP2R3A SFRP4	Q06190 Q6FHJ7 Q93052 Q9UGP4	0:0:0:0	hu.MAP

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	30950185

Sequence, Structure & Domains

Sequences

Length

612

Mass

65,746

Sequence

MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL

Domain & Motif Annotations

Compositional Bias

26..40; Polar residues; 41..53; Low complexity; 143..158; Polar residues; 171..181; Polar residues; 183..193; Pro residues; 209..219; Polar residues; 314..323; Polar residues

Domain (FT)

414..473; LIM zinc-binding 1; 474..534; LIM zinc-binding 2; 535..603; LIM zinc-binding 3

Region

1..118; Disordered; 132..219; Disordered; 307..387; Disordered

Protein Families

Zyxin/ajuba family

Sequence Similarities

Belongs to the zyxin/ajuba family.

Clinical Relevance

Disease Involvement

Cancer-related genes

Antibody (2)

HPA011133 HPA017342

Interaction Protein

ENSG00000105568

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications18

PMID	Title	Related sentences
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No related sentences available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No related sentences available
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No related sentences available
39207047	The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis.	No related sentences available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No related sentences available
40465195	Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome.	No related sentences available
40985879	TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins.	No related sentences available
41307968	Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.	No related sentences available

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