Protein detail
LPP
Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma)
Protein symbol LPP | UniProt ID | EVMP score 0.60 |
Frequency 18 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
LIM domain containing preferred translocation partner in lipoma
Chromosome
3
Position
188153284-188890671
Frequency
18
EVMP Score
0.60
Fluorescence & Localization
Cell SpecificAdipocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
- Disease related genes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence
Enzyme-Mediated Modification
8 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LPP | SRC | P12931 | Y | 301 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| LPP | SRC | P12931 | Y | 244 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| LPP | SRC | P12931 | Y | 300 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| LPP | EGFR | P00533 | Y | 301 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:15951569 |
| LPP | EGF | P01133 | S | 116 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
| LPP | IGF1R | P08069 | Y | 300 | phosphorylation | KEA | KEA:17570479 |
| LPP | INSR | P06213 | Y | 301 | phosphorylation | KEA | KEA:17570479 |
| LPP | LCK | P06239 | Y | 301 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| adhesion_cytoskeleton_adaptor | intracellular_intercellular_related | Adhesome | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | Cellinker | No | Yes | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SRC | P12931 | LPP | Q93052 | Yes | No | No | PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:28436416 |
Protein Complex Composition
28 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| LIMD1LPPPPP2R3ASFRP4ZNF580 | Q06190Q6FHJ7Q93052Q9UGP4Q9UK33 | 0:0:0:0:0 | hu.MAP2 | |||
| LIMD1LPPPPP2R3A | Q06190Q93052Q9UGP4 | 0:0:0 | hu.MAP2 | |||
| DOLPP1MMACHCSELENBP1TRMT5 | Q13228Q32P41Q86YN1Q9Y4U1 | 0:0:0:0 | hu.MAP2 | |||
| PLPPR1PLPPR3 | Q6T4P5Q8TBJ4 | 0:0 | hu.MAP | |||
| DNAAF11PHLPP2 | Q6ZVD8Q86X45 | 0:0 | hu.MAP2 | |||
| LPPSESTD1 | Q86VW0Q93052 | 0:0 | hu.MAP | |||
| C9orf40PLPPR2 | Q8IXQ3Q96GM1 | 0:0 | hu.MAPhu.MAP2 | |||
| LPPPNPO | Q93052Q9NVS9 | 0:0 | Havugimana2012 | Havugimana2012:C_67 |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30950185 |
Sequence, Structure & Domains
Sequences
Length
612
Mass
65,746
Sequence
MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL
3D Structural Models
Domain & Motif Annotations
Compositional Bias
26..40; Polar residues; 41..53; Low complexity; 143..158; Polar residues; 171..181; Polar residues; 183..193; Pro residues; 209..219; Polar residues; 314..323; Polar residues
Domain (FT)
414..473; LIM zinc-binding 1; 474..534; LIM zinc-binding 2; 535..603; LIM zinc-binding 3
Region
1..118; Disordered; 132..219; Disordered; 307..387; Disordered
Protein Families
Zyxin/ajuba family
Sequence Similarities
Belongs to the zyxin/ajuba family.