Protein detail

LPP

Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma)

Entry name LPP	UniProt ID Q93052	EVMP confidence score 0.60
Supporting publications (n) 18	Transmembrane count	Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma)

Protein Class (5)

Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (4)

Cancer-related genes:Mutational cancer driver genes
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000145012

Entrez Gene Symbol

LPP

Gene Description

LIM domain containing preferred translocation partner in lipoma

Chromosome

Position

188153284-188890671

Supporting publications (n)

EVMP confidence score

0.60

Fluorescence & Localization5

Cell SpecificAdipocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway5

Protein Function (4)

Cancer-related genes:Mutational cancer driver genes
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Disease related genes
Predicted intracellular proteins

Cellular Component (5)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence54

Enzyme-Mediated Modification (8)

8 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
LPP	SRC	P12931	Y	301	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
LPP	SRC	P12931	Y	244	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
LPP	SRC	P12931	Y	300	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
LPP	EGFR	P00533	Y	301	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:15951569
LPP	EGF	P01133	S	116	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:17081983
LPP	IGF1R	P08069	Y	300	phosphorylation	KEA	KEA:17570479
LPP	INSR	P06213	Y	301	phosphorylation	KEA	KEA:17570479
LPP	LCK	P06239	Y	301	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (16)

16 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
adhesion_cytoskeleton_adaptor	intracellular_intercellular_related	Adhesome	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	Cellinker	No	Yes	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SRC	P12931	LPP	Q93052	Yes	No	No	PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:28436416

Protein Complex Composition (28)

28 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
ClpP complexheptameric	CLPP	Q16740	7	CORUMPDB	PDB:6h23PDB:8ypaPDB:7uvmPDB:7uvnPDB:9dkvPDB:6bbaCORUM:3988PDB:8w7cPDB:9dkwPDB:7uvrPDB:6dl7PDB:1tg6PDB:7uvuPDB:8wuzPDB:7vp9PDB:8w7ePDB:8i7xPDB:7uw0PDB:9dqlPDB:7wh5PDB:9kufPDB:8ylbPDB:9dqkPDB:8hgk	16115876
ClpXP complex	CLPP CLPX	O76031 Q16740	2:14	CORUMCompleatComplexPortal	CORUM:3992intact:EBI-26301857Compleat:HC996PDB:6h23	16115876 14755292 15522782 31056398
LPP-PPP2CA-PPP2R3A complex	LPP PPP2CA Q9Z176	P67775 Q93052 Q9Z176	0:0:0	CORUM	CORUM:6159	26945059
	LPP PPP2R3A SFRP4 WTIP ZNF580	A6NIX2 Q06190 Q6FHJ7 Q93052 Q9UK33	0:0:0:0:0	hu.MAP2
	PLPP3 PLPPR1 PLPPR3	O14495 Q6T4P5 Q8TBJ4	0:0:0	hu.MAP2
	CIT PLPP6 PPM1F	O14578 P49593 Q8IY26	0:0:0	hu.MAP
	EIF3A EIF3B EIF3C EIF3G EIF3H EIF3I EIF3J PHLPP1 PHLPP2 UBC USP1 USP12 USP38 USP46 WDR48	O15372 O60346 O75317 O75821 O75822 O94782 P0CG48 P55884 P62068 Q13347 Q14152 Q6ZVD8 Q8NB14 Q8TAF3 Q99613	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8906
	BUD23 PHLPP1 REM1 SNX6	O43709 O60346 O75628 Q9UNH7	0:0:0:0	Havugimana2012	Havugimana2012:C_323
	PHLPP1 SNX1 SNX2 SNX6	O60346 O60749 Q13596 Q9UNH7	0:0:0:0	Havugimana2012	Havugimana2012:C_170
	PHLPP1 PHLPP2 SRP19 UBC USP1 USP12 USP35 USP46 WDR48	O60346 O75317 O94782 P09132 P0CG48 P62068 Q6ZVD8 Q8TAF3 Q9P2H5	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4042

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	30950185

Sequence, Structure & Domains8

Sequences

Length

612

Mass

65,746

Sequence

MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKKFAPVVAPKPKYNPYKQPGGEGDFLPPPPPPLDDSSALPSISGNFPPPPPLDEEAFKVQGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTTASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYAAGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDELEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL

Domain & Motif Annotations

Compositional Bias

26..40; Polar residues; 41..53; Low complexity; 143..158; Polar residues; 171..181; Polar residues; 183..193; Pro residues; 209..219; Polar residues; 314..323; Polar residues

Domain (FT)

414..473; LIM zinc-binding 1; 474..534; LIM zinc-binding 2; 535..603; LIM zinc-binding 3

Region

1..118; Disordered; 132..219; Disordered; 307..387; Disordered

Protein Families

Zyxin/ajuba family

Sequence Similarities

Belongs to the zyxin/ajuba family.

Clinical Relevance5

Disease Involvement

Cancer-related genes

Antibody (2)

HPA011133 HPA017342

Interaction Protein

ENSG00000105568

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications18

PMID	Title	Abstract
27821849	Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation.	No abstract available
32560723	T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.	No abstract available
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
33441949	Utility of Claudin-3 in extracellular vesicles from human bile as biomarkers of cholangiocarcinoma.	No abstract available
33592500	A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.	No abstract available
35119778	Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis.	No abstract available
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No abstract available
36497184	Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells.	No abstract available
36982312	Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available

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