Protein detail
TP4A1
Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)
Entry name TP4A1 | UniProt ID | EVMP confidence score 0.35 |
Supporting publications (n) 0 | Transmembrane count | Protein classification EnzymesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)
Protein Class (2)
EnzymesPredicted intracellular proteins
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
PRL-1PRL1PTPCAAX1
Gene Description
Protein tyrosine phosphatase 4A1
Chromosome
6
Position
63521746-63583588
Supporting publications (n)
0
EVMP confidence score
0.35
Fluorescence & Localization
Tissue SpecifictestisCell SpecificDifferentiating spermatogoniaSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway
Protein Function (3)
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component (6)
Molecular Function (2)
Biological Process (3)
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence11
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| WEE1 | P30291 | TP4A1 | Q93096 | Yes | Yes | SIGNOR | SIGNOR:33450002 |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| NA | Western Blotting | 1 | 34167524 |
Sequence, Structure & Domains
Sequences
Length
173
Mass
19,815
Sequence
MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ
3D Structural Models
Turn
109..111
Helix
27..29; 30..39; 56..60; 78..94; 112..121; 126..134; 143..151
Beta Strand
10..14; 17..21; 42..47; 64..67; 72..74; 99..103; 105..108
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Domain (FT)
8..161; Tyrosine-protein phosphatase
Region
97..132; Interaction with ATF5
Protein Families
Protein-tyrosine phosphatase family
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family.
Clinical Relevance
Drugs
Antibody
Interaction Protein (3)
ENSG00000119946ENSG00000158158ENSG00000184007
Interaction Count
3
Interaction Dataset (3)
intact_biogridbiogrid_bioplexintact_biogrid_bioplex