Protein detail

TP4A1

Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)

Protein symbol TP4A1	UniProt ID Q93096	EVMP score 0.38
Frequency	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

Basic Information

Protein Names

Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)

Protein Class

EnzymesPredicted intracellular proteins

Protein Function

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Ensembl

ENSG00000112245

Entrez Gene Symbol

PTP4A1

Gene Synonym

PRL-1PRL1PTPCAAX1

Gene Description

Protein tyrosine phosphatase 4A1

Chromosome

Position

63521746-63583588

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecifictestisCell SpecificDifferentiating spermatogoniaSingle-Nuclei Brain Specificoligodendrocyte

Function & Pathway

Protein Function

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Fusion and delivery mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
WEE1	P30291	TP4A1	Q93096	Yes	No	Yes	SIGNOR	SIGNOR:33450002

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PTP4A1 PTP4A2	Q12974 Q93096	0:0	hu.MAP2
	PTP4A1	Q93096	3	PDB	PDB:1xm2PDB:1rxdPDB:9mex

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
NA	Western Blotting	1	34167524

Sequence, Structure & Domains

Sequences

Length

173

Mass

19,815

Sequence

MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ

3D Structural Models

Turn

109..111

Helix

27..29; 30..39; 56..60; 78..94; 112..121; 126..134; 143..151

Beta Strand

10..14; 17..21; 42..47; 64..67; 72..74; 99..103; 105..108

3D Structure

X-ray crystallography (4)

Domain & Motif Annotations

Domain (FT)

8..161; Tyrosine-protein phosphatase

Region

97..132; Interaction with ATF5

Protein Families

Protein-tyrosine phosphatase family

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family.

Clinical Relevance

Drugs

HALOFUGINONE

Antibody

HPA003281

Interaction Protein

ENSG00000119946ENSG00000158158ENSG00000184007

Interaction Count

Interaction Dataset

intact_biogridbiogrid_bioplexintact_biogrid_bioplex