Protein detail

NKD2

Protein naked cuticle homolog 2 (Naked-2) (hNkd2)

Entry name
NKD2
UniProt ID
Q969F2
EVMP confidence score
0.35
Supporting publications (n)
0
Transmembrane count
Protein classification
Predicted intracellular proteins
Basic Information
Protein Names
Protein naked cuticle homolog 2 (Naked-2) (hNkd2)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000145506
Entrez Gene Symbol
NKD2
Gene Synonym
Naked2
Gene Description
NKD inhibitor of WNT signaling pathway 2
Chromosome
5
Position
1008802-1038943
Supporting publications (n)
0
EVMP confidence score
0.35
Fluorescence & Localization
Tissue Specificparathyroid glandCell SpecificMacrophagesSecretome LocationSecreted to bloodSecretome FunctionGrowth factor
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (7)
Molecular Function (7)
Biological Process (3)
KEGG (2)
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence15

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
NKD2PRKCQQ04759S31phosphorylationPhosphoSite
NKD2PRKACAP17612S223phosphorylationPhosphoSite

Ligand-Receptor Signaling (8)

8 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ecmecmOmniPathYes
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
plasma_membraneplasma_membraneUniProt_location
plasma_membraneplasma_membraneOmniPath
ecmecmCellinkerYes

Regulatory Interaction Network (4)

4 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
RNF25Q96BH1NKD2Q969F2YesYesSIGNORSIGNOR:18757723
TGFAP01135NKD2Q969F2YesYesCellinkerHINTSIGNORHPRDHINT:15064403HINT:18757723Cellinker:27635238SIGNOR:18757723HPRD:15064403
KAPCAP17612NKD2Q969F2YesPhosphoSitePhosphoSite_ProtMapperProtMapperPhosphoSite:30941853
KPCTQ04759NKD2Q969F2YesPhosphoSitePhosphoSite_ProtMapperProtMapperPhosphoSite:34433025

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationWestern blottingMass spectrometry134185707
Sequence, Structure & Domains

Sequences

Length
451
Mass
50,055
Sequence
MGKLQSKHAAAARKRRESPEGDSFVASAYASGRKGAEEAERRARDKQELPNGDPKEGPFREDQCPLQVALPAEKAEGREHPGQLLSADDGERAANREGPRGPGGQRLNIDALQCDVSVEEDDRQEWTFTLYDFDNCGKVTREDMSSLMHTIYEVVDASVNHSSGSSKTLRVKLTVSPEPSSKRKEGPPAGQDREPTRCRMEGELAEEPRVADRRLSAHVRRPSTDPQPCSERGPYCVDENTERRNHYLDLAGIENYTSRFGPGSPPVQAKQEPQGRASHLQARSRSQEPDTHAVHHRRSQVLVEHVVPASEPAARALDTQPRPKGPEKQFLKSPKGSGKPPGVPASSKSGKAFSYYLPAVLPPQAPQDGHHLPQPPPPPYGHKRYRQKGREGHSPLKAPHAQPATVEHEVVRDLPPTPAGEGYAVPVIQRHEHHHHHEHHHHHHHHHFHPS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q969F2-1; Sequence=Displayed; Name=2; IsoId=Q969F2-2; Sequence=VSP_027900, VSP_027901
Alternative Sequence
265..311; PPVQAKQEPQGRASHLQARSRSQEPDTHAVHHRRSQVLVEHVVPASE -> QLCEKRSSAPRTHSGDKARGVGLCRELWSQAGHPQWPGPFPSGLVAV (in isoform 2); 312..451; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias
34..63; Basic and acidic residues; 89..99; Basic and acidic residues; 180..215; Basic and acidic residues; 332..351; Low complexity
Domain (CC)
The N-terminal domain comprising the first 217 amino acid residues is mostly unstructured.
Domain (FT)
119..154; EF-hand
Region
1..108; Disordered; 2..173; Targeting to the basolateral cell membrane; 113..178; Interaction with DVL1, DVL2 and DVL3; 162..237; Disordered; 256..408; Disordered; 300..385; Interaction with TGFA
Protein Families
NKD family
Sequence Similarities
Belongs to the NKD family.
Clinical Relevance
Antibody
HPA049463
Interaction Protein (3)
ENSG00000108953ENSG00000163743ENSG00000164924
Interaction Count
3
Interaction Dataset (2)
biogrid_opencellintact_biogrid