Protein detail
NKD2
Protein naked cuticle homolog 2 (Naked-2) (hNkd2)
Protein symbol NKD2 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count | Protein classification Predicted intracellular proteins |
Basic Information
Protein Names
Protein naked cuticle homolog 2 (Naked-2) (hNkd2)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
Naked2
Gene Description
NKD inhibitor of WNT signaling pathway 2
Chromosome
5
Position
1008802-1038943
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificparathyroid glandCell SpecificMacrophagesSecretome LocationSecreted to bloodSecretome FunctionGrowth factor
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| ecm | ecm | Cellinker | Yes | No | No | No | No |
Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| RNF25 | Q96BH1 | NKD2 | Q969F2 | Yes | No | Yes | SIGNOR | SIGNOR:18757723 |
| TGFA | P01135 | NKD2 | Q969F2 | Yes | Yes | No | CellinkerHINTSIGNORHPRD | HINT:15064403HINT:18757723Cellinker:27635238SIGNOR:18757723HPRD:15064403 |
| KAPCA | P17612 | NKD2 | Q969F2 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:30941853 |
| KPCT | Q04759 | NKD2 | Q969F2 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:34433025 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blottingMass spectrometry | 1 | 34185707 |
Sequence, Structure & Domains
Sequences
Length
451
Mass
50,055
Sequence
MGKLQSKHAAAARKRRESPEGDSFVASAYASGRKGAEEAERRARDKQELPNGDPKEGPFREDQCPLQVALPAEKAEGREHPGQLLSADDGERAANREGPRGPGGQRLNIDALQCDVSVEEDDRQEWTFTLYDFDNCGKVTREDMSSLMHTIYEVVDASVNHSSGSSKTLRVKLTVSPEPSSKRKEGPPAGQDREPTRCRMEGELAEEPRVADRRLSAHVRRPSTDPQPCSERGPYCVDENTERRNHYLDLAGIENYTSRFGPGSPPVQAKQEPQGRASHLQARSRSQEPDTHAVHHRRSQVLVEHVVPASEPAARALDTQPRPKGPEKQFLKSPKGSGKPPGVPASSKSGKAFSYYLPAVLPPQAPQDGHHLPQPPPPPYGHKRYRQKGREGHSPLKAPHAQPATVEHEVVRDLPPTPAGEGYAVPVIQRHEHHHHHEHHHHHHHHHFHPS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q969F2-1; Sequence=Displayed; Name=2; IsoId=Q969F2-2; Sequence=VSP_027900, VSP_027901
Alternative Sequence
265..311; PPVQAKQEPQGRASHLQARSRSQEPDTHAVHHRRSQVLVEHVVPASE -> QLCEKRSSAPRTHSGDKARGVGLCRELWSQAGHPQWPGPFPSGLVAV (in isoform 2); 312..451; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
34..63; Basic and acidic residues; 89..99; Basic and acidic residues; 180..215; Basic and acidic residues; 332..351; Low complexity
Domain (CC)
The N-terminal domain comprising the first 217 amino acid residues is mostly unstructured.
Domain (FT)
119..154; EF-hand
Region
1..108; Disordered; 2..173; Targeting to the basolateral cell membrane; 113..178; Interaction with DVL1, DVL2 and DVL3; 162..237; Disordered; 256..408; Disordered; 300..385; Interaction with TGFA
Protein Families
NKD family
Sequence Similarities
Belongs to the NKD family.
Clinical Relevance
Antibody
Interaction Protein
ENSG00000108953ENSG00000163743ENSG00000164924
Interaction Count
3
Interaction Dataset
biogrid_opencellintact_biogrid