Protein detail

CAVN3

Caveolae-associated protein 3 (Cavin-3) (Protein kinase C delta-binding protein) (Serum deprivation response factor-related gene product that binds to C-kinase) (hSRBC)

Entry name CAVN3	UniProt ID Q969G5	EVMP confidence score 0.53
Supporting publications (n) 3	Transmembrane count	Protein classification Predicted intracellular proteins

Basic Information

Protein Names

Caveolae-associated protein 3 (Cavin-3) (Protein kinase C delta-binding protein) (Serum deprivation response factor-related gene product that binds to C-kinase) (hSRBC)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000170955

Entrez Gene Symbol

CAVIN3

Gene Synonym (5)

cavin-3HSRBCMGC20400PRKCDBPSRBC

Gene Description

Caveolae associated protein 3

Chromosome

Position

6318946-6320532

Supporting publications (n)

EVMP confidence score

0.53

Fluorescence & Localization

Tissue SpecificintestineCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (2)

Biological Process (3)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence8

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath
cavin_caveolae	intracellular_intercellular_related	HGNC	Yes
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CAVIN3 GOLIM4 ILF2 MFN1 NENF PTBP3 SARS2 SND1 TOMM22 TXN2	O00461 O95758 Q12905 Q7KZF4 Q8IWA4 Q969G5 Q99757 Q9NP81 Q9NS69 Q9UMX5	0:0:0:0:0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_581

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains

Sequences

Length

261

Mass

27,701

Sequence

MRESALERGPVPEAPAGGPVHAVTVVTLLEKLASMLETLRERQGGLARRQGGLAGSVRRIQSGLGALSRSHDTTSNTLAQLLAKAERVSSHANAAQERAVRRAAQVQRLEANHGLLVARGKLHVLLFKEEGEVPASAFQKAPEPLGPADQSELGPEQLEAEVGESSDEEPVESRAQRLRRTGLQKVQSLRRALSGRKGPAAPPPTPVKPPRLGPGRSAEAQPEAQPALEPTLEPEPPQDTEEDPGRPGAAEEALLQMESVA

Domain & Motif Annotations

Compositional Bias

158..170; Acidic residues; 200..212; Pro residues; 213..231; Low complexity

Domain (CC)

The leucine-zipper domain is essential for its localization in the caveolae and for its interaction with CAV1 and EPS15L1..

Region

1..84; Interaction with CAVIN1; 20..78; Leucine-zipper; 135..203; Interaction with CAV1; 139..261; Disordered

Protein Families

CAVIN family

Sequence Similarities

Belongs to the CAVIN family.

Clinical Relevance

Disease Involvement

Tumor suppressor

Antibody (2)

HPA055136 HPA073327

Interaction Protein (4)

ENSG00000143549ENSG00000177469ENSG00000178988ENSG00000179010

Interaction Count

Interaction Dataset (2)

intact_biogridintact_biogrid_bioplex

Supporting Publications3

PMID	Title	Related sentences
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No related sentences available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No related sentences available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No related sentences available