Protein detail

MAL2

Protein MAL2

Entry name MAL2	UniProt ID Q969L2	EVMP confidence score 0.38
Supporting publications (n)	Transmembrane count 4	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Protein MAL2

Protein Class

Predicted membrane proteins

Transmembrane

35..55; Helical; 67..87; Helical; 103..123; Helical; 150..170; Helical

Transmembrane Count

Ensembl

ENSG00000147676

Entrez Gene Symbol

MAL2

Gene Description

Mal, T cell differentiation protein 2

Chromosome

Position

119165034-119245673

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecifictestisCell SpecificEarly spermatidsSingle-Nuclei Brain Specificependymal cell

Function & Pathway4

Cellular Component (8)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence24

Ligand-Receptor Signaling (17)

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	GO_Intercell	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No

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Protein Complex Composition (6)

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CLOCK/BMAL2	BMAL2 CLOCK	O15516 Q8WYA1	1:1	SIGNORComplexPortal	intact:EBI-9696951SIGNOR:SIGNOR-C196	23887727 14755292
	BMAL1 BMAL2 CIPC CLOCK MANEA NPAS2 OLFM1	O00327 O15516 Q5SRI9 Q8WYA1 Q99743 Q99784 Q9C0C6	0:0:0:0:0:0:0	hu.MAP2
	BMAL1 BMAL2 CIPC CLOCK NPAS2 OLFM1	O00327 O15516 Q8WYA1 Q99743 Q99784 Q9C0C6	0:0:0:0:0:0	hu.MAP2
	BMAL2 MANEA OLFM1 OLFM2	O95897 Q5SRI9 Q8WYA1 Q99784	0:0:0:0	hu.MAP
	BMAL2 MANEA NPAS2 OLFM1	Q5SRI9 Q8WYA1 Q99743 Q99784	0:0:0:0	hu.MAP2
	BMAL2 NPAS2 OLFM1	Q8WYA1 Q99743 Q99784	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	34186243

Sequence, Structure & Domains6

Sequences

Length

176

Mass

19,125

Sequence

MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVPLPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLEAAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP

Domain & Motif Annotations

Domain (FT)

31..175; MARVEL

Protein Families

MAL family

Sequence Similarities

Belongs to the MAL family.

Clinical Relevance4

Antibody

HPA043831

Interaction Protein

ENSG00000128683

Interaction Count

Interaction Dataset

intact_biogrid