Protein detail

MRGRF

Mas-related G-protein coupled receptor member F (Mas-related gene F protein) (G-protein coupled receptor 140) (G-protein coupled receptor 168)

Entry name MRGRF	UniProt ID Q96AM1	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Mas-related G-protein coupled receptor member F (Mas-related gene F protein) (G-protein coupled receptor 140) (G-protein coupled receptor 168)

Protein Class (4)

G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (3)

Transporters
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

45..66; Helical; Name=1; 83..104; Helical; Name=2; 124..144; Helical; Name=3; 161..181; Helical; Name=4; 199..220; Helical; Name=5; 242..263; Helical; Name=6; 274..294; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000172935

Entrez Gene Symbol

MRGPRF

Gene Synonym (4)

GPR140GPR168MGC21621mrgF

Gene Description

MAS related GPR family member F

Chromosome

Position

69004395-69013382

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue SpecifickidneyCell SpecificProximal tubule cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway5

Protein Function (3)

Transporters
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (2)

Molecular Function

GO:0004930 G protein-coupled receptor activity

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence40

Ligand-Receptor Signaling (39)

39 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
rhodopsin	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_a	receptor	HPMR	No	Yes	No	Yes	No
mas_related_7tm_a	receptor	HPMR	No	Yes	No	Yes	No
rhodopsin	receptor	Surfaceome	No	Yes	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	16	34186243 27863537 33035814 39766158 36398564 37786918 39409015 37205098 34817906 28986585 27894104 30646616 38321535 29148239 35194965 32089743

Sequence, Structure & Domains6

Sequences

Length

343

Mass

38,171

Sequence

MAGNCSWEAHPGNRNKMCPGLSEAPELYSRGFLTIEQIAMLPPPAVMNYIFLLLCLCGLVGNGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVCRVLGLCMFLTGVSLLPAVSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLGRGAPGAACRHMDIFLGILLFLLCCPLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVTDLCICINSSAKPIVYFLAGRDKSQRLWEPLRVVFQRALRDGAELGEAGGSTPNTVTMEMQCPPGNAS

Domain & Motif Annotations

Region

320..343; Disordered

Protein Families (2)

G-protein coupled receptor 1 family
Mas subfamily

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Clinical Relevance1

Antibody

HPA028811

Supporting Publications1

PMID	Title	Abstract
30550287	Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.	No abstract available