Protein detail

S67A1

Solute carrier family 67 member A1 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein) (Efflux transporter-like protein) (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Organic cation transporter-like protein 2) (ORCTL-2) (Solute carrier family 22 member 1-like) (Solute carrier family 22 member 18) (Tumor-suppressing STF cDNA 5 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein) (p45-Beckwith-Wiedemann region 1 A) (p45-BWR1A)

Entry name
S67A1
UniProt ID
Q96BI1
EVMP confidence score
0.50
Supporting publications (n)
2
Transmembrane count
10
Protein classification
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information13
Protein Names
Solute carrier family 67 member A1 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein) (Efflux transporter-like protein) (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Organic cation transporter-like protein 2) (ORCTL-2) (Solute carrier family 22 member 1-like) (Solute carrier family 22 member 18) (Tumor-suppressing STF cDNA 5 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein) (p45-Beckwith-Wiedemann region 1 A) (p45-BWR1A)
Protein Class (6)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (5)
  • Human disease related genes:Cancers:Cancers of the breast and female genital organs
  • Potential drug targets
  • Transporters:Electrochemical Potential-driven transporters
  • Disease related genes
  • Human disease related genes:Cancers:Cancers of soft tissues and bone
Transmembrane
26..46; Helical; 59..79; Helical; 90..110; Helical; 156..176; Helical; 184..204; Helical; 243..263; Helical; 276..296; Helical; 312..332; Helical; 334..354; Helical; 391..411; Helical
Transmembrane Count
10
Ensembl
ENSG00000110628
Entrez Gene Symbol
SLC22A18
Gene Synonym (7)
BWR1ABWSCR1AIMPT1ITMORCTL2SLC22A1LTSSC5
Gene Description
Solute carrier family 22 member 18
Chromosome
11
Position
2899721-2925246
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue SpecificbrainCell SpecificNeutrophilsBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway6
Protein Function (5)
  • Human disease related genes:Cancers:Cancers of the breast and female genital organs
  • Potential drug targets
  • Transporters:Electrochemical Potential-driven transporters
  • Disease related genes
  • Human disease related genes:Cancers:Cancers of soft tissues and bone
Cellular Component (5)
Molecular Function (4)
Biological Process (3)
Reactome (5)
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence1

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometryMass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF]Small R sequencing (Illumi HiSeq 2000 (Solexa)434186243291482393040859139409015
Sequence, Structure & Domains5

Sequences

Length
424
Mass
44,846
Sequence
MQGARAPRDQGRSPGRMSALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWRKPMPQRKDKVR

Domain & Motif Annotations

Protein Families (2)
  • Major facilitator (TC 2.A.1) superfamily
  • Organic cation transporter (TC 2.A.1.19) family
Sequence Similarities
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Clinical Relevance5
Disease Involvement
Disease variant
Antibody (2)
HPA067812HPA071461
Interaction Protein
ENSG00000014824
Interaction Count
1
Interaction Dataset
biogrid_bioplex
Supporting Publications2
PMIDTitleAbstract
38037300Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.No abstract available
39996590Surface Double Dendritic Magnetic Microfibrils for Rapid Isolation and Proteomic Profiling of Extracellular Vesicles from Microliters of Biofluids.No abstract available