Protein detail

ELMO3

Engulfment and cell motility protein 3

Entry name ELMO3	UniProt ID Q96BJ8	EVMP score 0.38
Frequency 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Engulfment and cell motility protein 3

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000102890

Entrez Gene Symbol

ELMO3

Gene Synonym

CED-12CED12ELMO-3FLJ13824

Gene Description

Engulfment and cell motility 3

Chromosome

Position

67199111-67204029

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBreast hormone-responsive cellsSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005737 cytoplasm

Molecular Function

Biological Process

KEGG

hsa05100 Bacterial invasion of epithelial cells

Mediation Categories

Fusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
engulfment_motility	intracellular_intercellular_related	HGNC	No	Yes	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	DOCK1 ELMO3	Q14185 Q96BJ8	0:0	KEGG-MEDICUShu.MAP2
	ANKRD54 DOCK5 ELMO1 ELMO2 ELMO3 ZHX2	Q6NXT1 Q92556 Q96BJ8 Q96JJ3 Q9H7D0 Q9Y6X8	0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	27821849

Sequence, Structure & Domains

Sequences

Length

720

Mass

81,467

Sequence

MAPPRNVVKIAIKMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLTHSERYALQFADGHRRYITENNRAEIKNGSILCLSTAPDLEAEQLLGGLQSNSPEGRREALRRLVPLASDMIFAREVISRNGLQILGTIIEDGDDLGEVLALSLRAFSELMEHGVVSWETLSIPFVRKVVCYVNMNLMDASVPPLALGLLESVTLSSPALGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQGASPVERKHMLDYLWQRNLRQFIYKNIIHSAAPMGDEMAHHLYVLQALMLGLLEPRMRTPLDPYSQEQREQLQVLRQAAFEVEGESSGAGLSADRRRSLCAREFRKLGFSNSNPAQDLERVPPGLLALDNMLYFSRNAPSAYSRFVLENSSREDKHECPFARGSIQLTVLLCELLRVGEPCSETAQDFSPMFFGQDQSFHELFCVGIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGTLFRKISSRRRQDKLWFCCLSPNHKLLQYGDMEEGASPPTLESLPEQLPVADMRALLTGKDCPHVREKGSGKQNKDLYELAFSISYDRGEEEAYLNFIAPSKREFYLWTDGLSALLGSPMGSEQTRLDLEQLLTMETKLRLLELENVPIPERPPPVPPPPTNFNFCYDCSIAEP

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=Q96BJ8-1; Sequence=Displayed; Name=1; IsoId=Q96BJ8-2; Sequence=VSP_037341; Name=3; IsoId=Q96BJ8-3; Sequence=VSP_037342

Alternative Sequence

1..113; Missing (in isoform 1); 1; M -> MARSSSLGRECGTPRSGLGKGGPPRPQGPQARCTLGRRCTVSGKCRRPRPSWTM (in isoform 3)

3D Structural Models

Domain & Motif Annotations

Motif

696..706; SH3-binding

Domain (FT)

307..479; ELMO; 542..664; PH

Clinical Relevance

Antibody

HPA021484