Protein detail

ELMO3

Engulfment and cell motility protein 3

Entry name ELMO3	UniProt ID Q96BJ8	EVMP confidence score 0.53
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

Basic Information

Protein Names

Engulfment and cell motility protein 3

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000102890

Entrez Gene Symbol

ELMO3

Gene Synonym (4)

CED-12CED12ELMO-3FLJ13824

Gene Description

Engulfment and cell motility 3

Chromosome

Position

67199111-67204029

Supporting publications (n)

EVMP confidence score

0.53

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBreast hormone-responsive cellsSingle-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005737 cytoplasm

Molecular Function (2)

Biological Process (3)

KEGG

hsa05100 Bacterial invasion of epithelial cells

Mediation Categories (2)

Fusion and delivery mediationImmune mediation

Relations & Evidence10

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver
intracellular	intracellular	LOCATE
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath
engulfment_motility	intracellular_intercellular_related	HGNC		Yes
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	DOCK1 ELMO3	Q14185 Q96BJ8	0:0	KEGG-MEDICUShu.MAP2
	ANKRD54 DOCK5 ELMO1 ELMO2 ELMO3 ZHX2	Q6NXT1 Q92556 Q96BJ8 Q96JJ3 Q9H7D0 Q9Y6X8	0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	27821849

Sequence, Structure & Domains

Sequences

Length

720

Mass

81,467

Sequence

MAPPRNVVKIAIKMRDAIPQLIQLDQAKPLAAVLKEVCDAWSLTHSERYALQFADGHRRYITENNRAEIKNGSILCLSTAPDLEAEQLLGGLQSNSPEGRREALRRLVPLASDMIFAREVISRNGLQILGTIIEDGDDLGEVLALSLRAFSELMEHGVVSWETLSIPFVRKVVCYVNMNLMDASVPPLALGLLESVTLSSPALGQLVKSEVPLDRLLVHLQVMNQQLQTKAMALLTALLQGASPVERKHMLDYLWQRNLRQFIYKNIIHSAAPMGDEMAHHLYVLQALMLGLLEPRMRTPLDPYSQEQREQLQVLRQAAFEVEGESSGAGLSADRRRSLCAREFRKLGFSNSNPAQDLERVPPGLLALDNMLYFSRNAPSAYSRFVLENSSREDKHECPFARGSIQLTVLLCELLRVGEPCSETAQDFSPMFFGQDQSFHELFCVGIQLLNKTWKEMRATQEDFDKVMQVVREQLARTLALKPTSLELFRTKVNALTYGEVLRLRQTERLHQEGTLAPPILELREKLKPELMGLIRQQRLLRLCEGTLFRKISSRRRQDKLWFCCLSPNHKLLQYGDMEEGASPPTLESLPEQLPVADMRALLTGKDCPHVREKGSGKQNKDLYELAFSISYDRGEEEAYLNFIAPSKREFYLWTDGLSALLGSPMGSEQTRLDLEQLLTMETKLRLLELENVPIPERPPPVPPPPTNFNFCYDCSIAEP

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=2; IsoId=Q96BJ8-1; Sequence=Displayed; Name=1; IsoId=Q96BJ8-2; Sequence=VSP_037341; Name=3; IsoId=Q96BJ8-3; Sequence=VSP_037342

Alternative Sequence

1..113; Missing (in isoform 1); 1; M -> MARSSSLGRECGTPRSGLGKGGPPRPQGPQARCTLGRRCTVSGKCRRPRPSWTM (in isoform 3)

Domain & Motif Annotations

Motif

696..706; SH3-binding

Domain (FT)

307..479; ELMO; 542..664; PH

Clinical Relevance

Antibody

HPA021484

Supporting Publications2

PMID	Title	Related sentences
30022183	An exosomal- and interfacial-biosensing based strategy for remote monitoring of aberrantly phosphorylated proteins in lung cancer cells.	Herein, we demonstrate that key lung cancer phosphoproteins, such as EGFR and ERK, are expressed in lung cancer exosomes and we outline a new exosomal proteomic-based approach for their fast and convenient detection. Using single-use and inexpensive, gold (Au) screen-printed electrodes (SPEs), we demonstrate the successful detection of aberrantly phosphorylated EGFR and ERK protein isoforms derived from lung cancer cell exosomes with a sensitivity down to 15 ng μL-1 in samples with up to 90% excess of their non-phosphorylated (wild-type) forms.
37503786	Modulation of PD‑L1 expression by standard therapy in head and neck cancer cell lines and exosomes.	No related sentences available