Protein detail

LENG1

Leukocyte receptor cluster member 1

Entry name LENG1	UniProt ID Q96BZ8	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Leukocyte receptor cluster member 1

Protein Class (2)

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000105617

Entrez Gene Symbol

LENG1

Gene Description

Leukocyte receptor cluster member 1

Chromosome

Position

54155161-54159721

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue SpecificepididymisCell SpecificCytotrophoblastsSingle-Nuclei Brain Specificfibroblast

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

Reactome (3)

Mediation Categories

Other mediation

Relations & Evidence9

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (5)

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
CDC40 LENG1 NCBP1 NCBP2 PHAX	O60508 P52298 Q09161 Q96BZ8 Q9H814	0:0:0:0:0	hu.MAP2
LENG1 NCBP1 NCBP2 PHAX SRRT	P52298 Q09161 Q96BZ8 Q9BXP5 Q9H814	0:0:0:0:0	hu.MAP2
LENG1 NCBP1 NCBP2 PHAX	P52298 Q09161 Q96BZ8 Q9H814	0:0:0:0	hu.MAP2
LENG1 NCBP2 USP45	P52298 Q70EL2 Q96BZ8	0:0:0	hu.MAP
LENG1 NCBP2	P52298 Q96BZ8	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	36982991 38922971

Sequence, Structure & Domains6

Sequences

Length

264

Mass

30,528

Sequence

MNILPKKSWHVRNKDNVARVRRDEAQAREEEKERERRVLLAQQEARTEFLRKKARHQNSLPELEAAEAGAPGSGPVDLFRELLEEGKGVIRGNKEYKEEKRQEKERQEKALGILTYLGQSAAEAQTQPPWYQLPPGRGGPPPGPAPDEKIKSRLDPLREMQKHLGKKRQHGGDEGSRSRKEKEGSEKQRPKEPPSLDQLRAERLRREAAERSRAEALLARVQGRALQEGQPEEDETDDRRRRYNSQFNPQLARRPRQQDPHLTH

Domain & Motif Annotations

Compositional Bias

12..37; Basic and acidic residues; 59..75; Low complexity; 146..162; Basic and acidic residues; 170..214; Basic and acidic residues

Coiled Coil

16..46; 89..115; 196..222

Region

1..37; Disordered; 49..76; Disordered; 118..264; Disordered

Clinical Relevance4

Antibody

HPA043541

Interaction Protein (3)

ENSG00000019995ENSG00000094796ENSG00000100109

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications3

PMID	Title	Abstract
35058120	Low-density lipoprotein receptor and apolipoprotein A 5, myocardial infarction biomarkers in plasma-derived exosomes.	In this study, we detected the levels of LDLR, APOA5, and cardiac troponin T in plasma-derived exosomes in MI patients and age-matched healthy people by enzyme linked immunosorbent assay and observed the morphology and number of exosomes using transmission electron microscope and nanoparticle tracking analysis. We found that the levels of LDLR and APOA5 in plasma-derived exosomes in MI patients were significantly decreased.
37322492	Exosomal circ_0008285 in follicle fluid regulates the lipid metabolism through the miR-4644/ LDLR axis in polycystic ovary syndrome.	The intercellular experiments on circ_0008285 and its reduction in KGN cells showed that the consumption of circ_0008285 in exosomes could increase the expression of miR-4644 in recipient cells and inhibit the expression of LDLR, as well as increase free fatty acid secretion.
38942135	IGFBP6 regulates extracellular vesicles formation via cholesterol abundance in MDA-MB-231 cells.	In this study, we demonstrated that the knockdown of the IGFBP6 gene, a highly selective inhibitor of IGF-II, led to a significant decline in the number of secreted extracellular vesicles (EVs) and altered cholesterol metabolism in MDA-MB-231 cells.